Výsledky vyhledávání - "Kyle M, Sousa"

Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice

Autor: Jingyan Tian, Eryun Zhang, David D. Moore, Zhipeng Fang, Yangmeng Wang, Bingning Dong, Lihua Jin, Kyle M. Sousa, Li Yang, Hongli Zhang, Xiaoxiao Ma, Jui Tu, Yixin Zhang, Qiaoling Yang, Wendong Huang, Zhengtao Wang, Ana Guan, Lili Ding

Publikováno v: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 6

Vertical sleeve gastrectomy (VSG) is one of the most effective and durable therapies for morbid obesity and its related complications. Although bile acids (BAs) have been implicated as downstream mediators of VSG, the specific mechanisms through whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1291de71f29c583ce5c4083c907bb55
https://europepmc.org/articles/PMC8017941/

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Bariatric surgery attenuates colitis in an obese murine model

Autor: Ninh T. Nguyen, Manuela Raffatellu, Alessio Vinci, Judith Behnsen, Kyle M. Sousa, Shiri Li, Chunmei Cheng, Robert Edwards, Michael J. Stamos, Alessio Pigazzi, Stefan Jellbauer

Publikováno v: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, vol 13, iss 4
Surg Obes Relat Dis
Li, S; Vinci, A; Behnsen, J; Cheng, C; Jellbauer, S; Raffatellu, M; et al.(2017). Bariatric surgery attenuates colitis in an obese murine model. SURGERY FOR OBESITY AND RELATED DISEASES, 13(4), 661-668. doi: 10.1016/j.soard.2016.10.024. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3hz8983g

Background Obesity and inflammatory bowel disease (IBD) represent chronic inflammatory conditions. Bariatric surgery improves some obesity-related co-morbidities, but the effects of bariatric surgery on IBD have not been well studied. Objectives To e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ae12a0ac667eb75eec129ce2ea64ca
https://escholarship.org/uc/item/3hz8983g

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Vertical sleeve gastrectomy activates GPBAR-1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

Autor: Ricardo Ramirez, Qiaoling Yang, Dustin Schones, Ying Gu, Byung-Wook Kim, Zhenzhou Xiao, Donna Yu, David D. Moore, Lili Ding, Zhengtao Wang, Jie Wang, Alessio Pigazzi, Wendong Huang, Bingning Dong, Kyle M. Sousa, Lihua Jin, Li Yang

Publikováno v: Hepatology (Baltimore, Md.). 64(3)

Vertical sleeve gastrectomy (VSG) is one of the most commonly performed clinical bariatric surgeries used for the remission of obesity and diabetes. However, the precise molecular mechanism by which VSG exerts its beneficial effects remains elusive.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9744f79f406d29c3b7f694f1a4c3de82
https://pubmed.ncbi.nlm.nih.gov/27312543

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Report of the 2017-2018 Academic Affairs Standing Committee

Autor: Kyle M. Sousa, Johnnie L. Early, Michael J. Gonyeau, Donald A. Godwin, Kelly M. Shields, Ruth E. Nemire, Michael Fulford, Sarah E. Griffin, Gail Beth Rattinger

Publikováno v: American Journal of Pharmaceutical Education. 82:7163

Introduction and Committee Charges The Bylaws of the American Association of Colleges of Pharmacy (AACP) state that the Academic Affairs Committee shall consider: the intellectual, social, and personal aspects of pharmaceutical education. It is expec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f490d14327455c4f1af20c9562420a0
https://doi.org/10.5688/ajpe7163

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The many facets of PPARγ: novel insights for the skeleton

Autor: Kyle M. Sousa, Clifford J. Rosen, Ormond A. MacDougald, Masanobu Kawai

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 299:E3-E9

Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor that functions as a master transcriptional regulator of adipocyte conversion. During PPARgamma transactivation, multiple signaling pathways interact with one another,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b71993febb719dbc7c0252d93620f8f
https://doi.org/10.1152/ajpendo.00157.2010

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Continuous-Flow Enzyme Assay on a Microfluidic Chip for Monitoring Glycerol Secretion from Cultured Adipocytes

Autor: Ormond A. MacDougald, Robert T. Kennedy, Anna M. Clark, Kyle M. Sousa, Colin Jennings

Publikováno v: Analytical Chemistry. 81:2350-2356

A dual-chip microfluidic platform that coupled perfusion of cultured adipocytes with on-line fluorescence-based enzyme assay was developed to monitor glycerol secretions in real time from cultured adipocytes. The perfusion cell chip, which could be r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49164c585393239de5de60a322a5b817
https://doi.org/10.1021/ac8026965

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Wnt10b Increases Postnatal Bone Formation by Enhancing Osteoblast Differentiation

Autor: Yanfei L. Ma, Hongjiao Ouyang, Christina N. Bennett, Kyle M. Sousa, Isabelle Gerin, Kurt D. Hankenson, Venkatesh Krishnan, Qingqiang Zeng, Timothy F. Lane, Ormond A. MacDougald

Publikováno v: Journal of Bone and Mineral Research. 22:1924-1932

Overexpression of Wnt10b from the osteocalcin promoter in transgenic mice increases postnatal bone mass. Increases in osteoblast perimeter, mineralizing surface, and bone formation rate without detectable changes in pre-osteoblast proliferation, oste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49dc9dbea9e962e0b255e57e83dfa50
https://doi.org/10.1359/jbmr.070810

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Microarray Analyses Support a Role for Nurr1 in Resistance to Oxidative Stress and Neuronal Differentiation in Neural Stem Cells

Autor: Anita C. Hall, Ernest Arenas, Lottie Jansson‐Sjöstrand, Moriaki Kusakabe, Kyle M. Sousa, Helena Mira

Publikováno v: Stem Cells. 25:511-519

Nurr1 is an orphan nuclear receptor required for the development of midbrain dopaminergic neurons. To better understand the molecular consequences of Nurr1 expression, we compared the transcriptomes of two independent control and Nurr1-expressing NSC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc562161570438703dafe26e7abfde9
https://doi.org/10.1634/stemcells.2006-0238

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Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion

Autor: Luísa Pinto, Ernest Arenas, Joseph Wagner, Vitezslav Bryja, Gonçalo Castelo-Branco, Kyle M. Sousa

Publikováno v: Molecular and Cellular Neuroscience. 31:251-262

Glial cells have been classically described as supporting cells for neurons. Recently, additional roles during neural development have begun to emerge. Here, we report that ventral midbrain glia, including astrocytes and radial glia, are the source o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588fa3f16a50efd31c3eb17f5ed5b3e5
https://doi.org/10.1016/j.mcn.2005.09.014

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Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor

Autor: Ken Mackie, Marton B. Dobszay, Sabrina M. Spano, Gunnar Schulte, Xinyu Wang, Yasmin L. Hurd, Patrik Ernfors, Paul Berghuis, Kyle M. Sousa, Tibor Harkany, Fernanda Ledda, Gustavo Paratcha

Publikováno v: Karolinska Institutet

In utero exposure to Δ 9 -tetrahydrocannabinol (Δ 9 -THC), the active component from marijuana, induces cognitive deficits enduring into adulthood. Although changes in synaptic structure and plasticity may underlie Δ 9 -THC-induced cognitive impai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231d2c2c652e33bf643a7a1e42335929
https://doi.org/10.1073/pnas.0509494102

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