Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kyle Leonard O'Hagan"'
Autor:
Hyewon Phee, Byron B Au-Yeung, Olga Pryshchep, Kyle Leonard O'Hagan, Stephanie Grace Fairbairn, Maria Radu, Rachelle Kosoff, Marianne Mollenauer, Debra Cheng, Jonathan Chernoff, Arthur Weiss
Publikováno v:
eLife, Vol 3 (2014)
The molecular mechanisms that govern thymocyte development and maturation are incompletely understood. The P21-activated kinase 2 (Pak2) is an effector for the Rho family GTPases Rac and Cdc42 that regulate actin cytoskeletal remodeling, but its role
Externí odkaz:
https://doaj.org/article/0f47d51dd4a94e00b110b8cfba0b5ab7
Publikováno v:
The Journal of Immunology. 195:5272-5284
NKT cells constitute a small population of T cells developed in the thymus that produce large amounts of cytokines and chemokines in response to lipid Ags. Signaling through the Vα14-Jα18 TCR instructs commitment to the NKT cell lineage, but the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96a32f84248eacc0cbc1dd19af2db49
https://doi.org/10.4049/jimmunol.1501367
https://doi.org/10.4049/jimmunol.1501367
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Foxp3, a key transcription factor that drives lineage differentiation of regulatory T cells (Tregs), was thought to imprint a unique and irreversible genetic signature within Tregs. Recent evidence, however, suggests that loss or attenuation of Foxp3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256d9d03d98054fde53961711af1cc84
https://doi.org/10.1038/s41598-017-17078-7
https://doi.org/10.1038/s41598-017-17078-7
Although significant effort has been devoted to understanding the thymic development of Foxp3+ regulatory T cells (Tregs), the precise signaling pathways that govern their lineage commitment still remain enigmatic. Our findings show a novel role for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa12a9bdf1ca01605e98734b915b4d0
https://europepmc.org/articles/PMC4530067/
https://europepmc.org/articles/PMC4530067/
Autor:
Jonathan Chernoff, Olga Pryshchep, Kyle Leonard O'Hagan, Rachelle Kosoff, Marianne Mollenauer, Debra A. Cheng, Stephanie Grace Fairbairn, Arthur Weiss, Hyewon Phee, Maria Radu, Byron B. Au-Yeung
Publikováno v:
eLife, Vol 3 (2014)
eLife, vol 3, iss 3
Phee, H; Au-Yeung, BB; Pryshchep, O; O'Hagan, KL; Fairbairn, SG; Radu, M; et al.(2014). Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. eLife, 2014(3). doi: 10.7554/eLife.02270. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7p08b232
eLife
eLife, vol 3, iss 3
Phee, H; Au-Yeung, BB; Pryshchep, O; O'Hagan, KL; Fairbairn, SG; Radu, M; et al.(2014). Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. eLife, 2014(3). doi: 10.7554/eLife.02270. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7p08b232
eLife
The molecular mechanisms that govern thymocyte development and maturation are incompletely understood. The P21-activated kinase 2 (Pak2) is an effector for the Rho family GTPases Rac and Cdc42 that regulate actin cytoskeletal remodeling, but its role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d553632de36f1e967ff718038560311
https://elifesciences.org/articles/02270
https://elifesciences.org/articles/02270
Autor:
Kyle Leonard O'Hagan, Olga Pryshchep, Maria Radu, Arthur Weiss, Rachelle Kosoff, Jonathan Chernoff, Byron B. Au-Yeung, Debra A. Cheng, Stephanie Grace Fairbairn, Marianne Mollenauer, Hyewon Phee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab6c9fb285f579565a9b23c0db5cbd3b
https://doi.org/10.7554/elife.02270.017
https://doi.org/10.7554/elife.02270.017