Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Kyle L. HOEHN"'
Autor:
Belinda Yau, Sheyda Naghiloo, Alexis Diaz-Vegas, Austin V. Carr, Julian Van Gerwen, Elise J. Needham, Dillon Jevon, Sing-Young Chen, Kyle L. Hoehn, Amanda E. Brandon, Laurence Macia, Gregory J. Cooney, Michael R. Shortreed, Lloyd M. Smith, Mark P. Keller, Peter Thorn, Mark Larance, David E. James, Sean J. Humphrey, Melkam A. Kebede
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108707- (2024)
Externí odkaz:
https://doaj.org/article/e31a11c153864f3ab3262542aac210c3
Autor:
Sing-Young Chen, Martina Beretta, Ellen M. Olzomer, Divya P. Shah, Derek Y.H. Wong, Stephanie J. Alexopoulos, Isabella Aleksovska, Joseph M. Salamoun, Christopher J. Garcia, Blake J. Cochran, Kerry-Anne Rye, Greg C. Smith, Frances L. Byrne, Margaret J. Morris, Webster L. Santos, James Cantley, Kyle L. Hoehn
Publikováno v:
Molecular Metabolism, Vol 69, Iss , Pp 101684- (2023)
Objective: Calorie restriction is a first-line treatment for overweight individuals with metabolic impairments. However, few patients can adhere to long-term calorie restriction. An alternative approach to calorie restriction that also causes negativ
Externí odkaz:
https://doaj.org/article/e475640495114e8b9f51a21417a66099
Autor:
Anna Veprik, Geoffrey Denwood, Dong Liu, Rula Bany Bakar, Valentin Morfin, Kara McHugh, Nchimunya N. Tebeka, Laurène Vetterli, Ekaterina Yonova-Doing, Fiona Gribble, Frank Reimann, Kyle L. Hoehn, Piers A. Hemsley, Jonas Ahnfelt-Rønne, Patrik Rorsman, Quan Zhang, Heidi de Wet, James Cantley
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Veprik et al. show that Acetyl-CoA-carboxylase 1 (ACC1), an enzyme that couples glucose metabolism to lipogenesis, is involved in glucagon secretion and regulates S-acylation of critical glucose-sensing proteins. Loss of ACC1 in pancreatic alpha-cell
Externí odkaz:
https://doaj.org/article/166afa66325d42c88ebcf56718483f72
Autor:
Elizabeth R. M. Zunica, Christopher L. Axelrod, Eunhan Cho, Guillaume Spielmann, Gangarao Davuluri, Stephanie J. Alexopoulos, Martina Beretta, Kyle L. Hoehn, Wagner S. Dantas, Krisztian Stadler, William T. King, Kathryn Pergola, Brian A. Irving, Ingeborg M. Langohr, Shengping Yang, Charles L. Hoppel, L. Anne Gilmore, John P. Kirwan
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-20 (2021)
Abstract Background Enhanced metabolic plasticity and diversification of energy production is a hallmark of highly proliferative breast cancers. This contributes to poor pharmacotherapy efficacy, recurrence, and metastases. We have previously identif
Externí odkaz:
https://doaj.org/article/73646908050a40a890022b3871277182
Autor:
Alexander J. Knights, Emily J. Vohralik, Peter J. Houweling, Elizabeth S. Stout, Laura J. Norton, Stephanie J. Alexopoulos, Jinfen. J. Yik, Hanapi Mat Jusoh, Ellen M. Olzomer, Kim S. Bell-Anderson, Kathryn N. North, Kyle L. Hoehn, Merlin Crossley, Kate G. R. Quinlan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Immune cells are important regulators of adipose tissue function, including adaptive thermogenesis. Here the authors show that mice with Krüppel-like factor 3 (KLF3) deficiency in bone marrow-derived cells have increased adipose tissue beiging which
Externí odkaz:
https://doaj.org/article/c3cf746046c44c4288224f72b4e3c524
Autor:
Stephanie J. Alexopoulos, Sing-Young Chen, Amanda E. Brandon, Joseph M. Salamoun, Frances L. Byrne, Christopher J. Garcia, Martina Beretta, Ellen M. Olzomer, Divya P. Shah, Ashleigh M. Philp, Stefan R. Hargett, Robert T. Lawrence, Brendan Lee, James Sligar, Pascal Carrive, Simon P. Tucker, Andrew Philp, Carolin Lackner, Nigel Turner, Gregory J. Cooney, Webster L. Santos, Kyle L. Hoehn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Obesity is a global pandemic with limited treatment options. Here, the authors show evidence in mice that the mitochondrial uncoupler BAM15 effectively induces fat loss without affecting food intake or compromising lean body mass.
Externí odkaz:
https://doaj.org/article/49822901a6bc47aea8285786f6119e85
Autor:
Belinda Yau, Sheyda Naghiloo, Alexis Diaz-Vegas, Austin V. Carr, Julian Van Gerwen, Elise J. Needham, Dillon Jevon, Sing-Young Chen, Kyle L. Hoehn, Amanda E. Brandon, Laurence Macia, Gregory J. Cooney, Michael R. Shortreed, Lloyd M. Smith, Mark P. Keller, Peter Thorn, Mark Larance, David E. James, Sean J. Humphrey, Melkam A. Kebede
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103099- (2021)
Summary: Pancreatic islets are essential for maintaining physiological blood glucose levels, and declining islet function is a hallmark of type 2 diabetes. We employ mass spectrometry-based proteomics to systematically analyze islets from 9 genetic o
Externí odkaz:
https://doaj.org/article/6eb4cfcc46fb42ea84ae3296431c3254
Autor:
Valentina RODRIGUEZ PARIS, Stephanie J. ALEXOPOULOS, Ying HU, Divya P. SHAH, Ali AFLATOUNIAN, Melissa C. EDWARDS, Michael J. BERTOLDO, Robert B. GILCHRIST, Kyle L. HOEHN, Kirsty A. WALTERS
Publikováno v:
Fertility & Reproduction, Vol 04, Iss 03n04, Pp 208-208 (2022)
Background: Polycystic ovary syndrome (PCOS) is a common endocrine condition characterized by endocrine, reproductive and metabolic abnormalities. There is no cure for PCOS and existing treatments are suboptimal. Obesity and adverse metabolic feature
Externí odkaz:
https://doaj.org/article/d923795257b04d2aaaed62399be9eef7
Autor:
Sing-Young Chen, Ellen M. Olzomer, Martina Beretta, James Cantley, Craig S. Nunemaker, Kyle L. Hoehn, Frances L. Byrne
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9798 (2022)
Obesity-related insulin resistance is a highly prevalent and growing health concern, which places stress on the pancreatic islets of Langerhans by increasing insulin secretion to lower blood glucose levels. The glucose transporters GLUT1 and GLUT3 pl
Externí odkaz:
https://doaj.org/article/11e2c49c4e454001b9ee519897b80eb4
Autor:
Yuantao Huo, Laura K. Buckton, Jack L. Bennett, Eloise C. Smith, Frances L. Byrne, Kyle L. Hoehn, Marwa N. Rahimi, Shelli R. McAlpine
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 728-739 (2019)
The most challenging issue facing peptide drug development is producing a molecule with optimal physical properties while maintaining target binding affinity. Masking peptides with protecting groups that can be removed inside the cell, produces a cel
Externí odkaz:
https://doaj.org/article/6788bb62f2ca40478336fde2257a8a2c