Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Kyle L Flannigan"'
Autor:
Zdeněk Dvořák, Felix Kopp, Cait M Costello, Jazmin S Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U Nordstroem, Chamini V Karunaratne, Harmit S Ranhotra, Kyu Shik Mun, Anjaparavanda P Naren, Iain A Murray, Gary H Perdew, Julius Brtko, Lucia Toporova, Arne Schön, Bret D Wallace, William G Walton, Matthew R Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L Flannigan, Simon A Hirota, Ryan Balfour Sartor, Sridhar Mani
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-19 (2020)
Abstract The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that esta
Externí odkaz:
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
Autor:
Mark Paul-Clark, Wagdi Elsheikh, Nicholas Kirkby, Melissa Chan, Pallavi Devchand, Terence A Agbor, Kyle L Flannigan, Charlotte Cheadle, Maxim Freydin, Angela Ianaro, Jane A Mitchell, John L Wallace
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147289 (2016)
Nonsteroidal anti-inflammatory drugs have been shown to reduce the incidence of gastrointestinal cancers, but the propensity of these drugs to cause ulcers and bleeding limits their use. H2S has been shown to be a powerful cytoprotective and anti-inf
Externí odkaz:
https://doaj.org/article/fd245ce58bce4fb7a72354c9cdeb2d65
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71962 (2013)
Hydrogen sulfide (H₂S) is produced throughout the gastrointestinal tract, and it contributes to maintenance of mucosal integrity, resolution of inflammation, and repair of damaged tissue. H₂S synthesis is elevated in inflamed and damaged colonic
Externí odkaz:
https://doaj.org/article/c374442c60a5488d92d4231fb41fa789
Autor:
Kyle L. Flannigan, Kristoff M. Nieves, Holly E. Szczepanski, Alex Serra, Joshua W. Lee, Laurie A. Alston, Hena Ramay, Sridhar Mani, Simon A. Hirota
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 3, Pp 765-795 (2023)
Background & Aims: Fibrosis is a common complication of inflammatory bowel diseases (IBDs). The pregnane X receptor (PXR) (encoded by NR1I2) suppresses intestinal inflammation and has been shown to influence liver fibrosis. In the intestine, PXR sign
Externí odkaz:
https://doaj.org/article/fe2e032f3ca34caba6075aaf93316e4c
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 322:G268-G281
The commensal bacteria that reside in the gastrointestinal tract exist in a symbiotic relationship with the host, driving the development of the immune system and maintaining metabolic and tissue homeostasis in the local environment. The intestinal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2335c6377b3ac28b07fa126362f119
https://doi.org/10.1152/ajpgi.00160.2021
https://doi.org/10.1152/ajpgi.00160.2021
Autor:
Holly E. Szczepanski, Kyle L. Flannigan, Barbara Mainoli, Laurie Alston, Grace M. Baruta, Joshua W. Lee, Vivek Krishna Pulakazhi Venu, Jane Shearer, Antoine Dufour, Simon A. Hirota
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(11)
Stricture formation is a common complication of Crohn's disease (CD), driven by enhanced deposition of extracellular matrix (ECM) and expansion of the intestinal smooth muscle layers. Nuclear receptor subfamily 4 group A member 1 (NR4A1) is an orphan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7730e513554dae837872c25f93aa87
https://pubmed.ncbi.nlm.nih.gov/36250380
https://pubmed.ncbi.nlm.nih.gov/36250380
Autor:
Kyle L. Flannigan, Kristoff M. Nieves, Holly E. Szczepanski, Alex Serra, Joshua W. Lee, Laurie A. Alston, Hena Ramay, Sridhar Mani, Simon A. Hirota
Publikováno v:
Cellular and molecular gastroenterology and hepatology.
Fibrosis is a common complication of inflammatory bowel diseases (IBDs). The pregnane X receptor (PXR) (encoded by NR1I2) suppresses intestinal inflammation and has been shown to influence liver fibrosis. In the intestine, PXR signaling is influenced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d82c644327c2b25b709b7b97da1d07
https://pubmed.ncbi.nlm.nih.gov/36309199
https://pubmed.ncbi.nlm.nih.gov/36309199
Autor:
Kyle L. Flannigan, Simon A. Hirota, Sridhar Mani, Daniel A. Muruve, Christina F. Sandall, Vivek Krishna Pulakazhi Venu, Grace Marie Hudson, Thomas K. H. Chang, Laurie Alston, Justin A. MacDonald
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
The pregnane X receptor (PXR) is a ligand-activated nuclear receptor that acts as a xenobiotic sensor, responding to compounds of foreign origin, including pharmaceutical compounds, environmental contaminants, and natural products, to induce transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0943f4234bc0a6c6b0754abae67696a8
https://doi.org/10.1124/jpet.118.255679
https://doi.org/10.1124/jpet.118.255679
Autor:
Chamini V. Karunaratne, Arne Schön, Iain A. Murray, Michelle C. Neary, Maria Maddalena Cavalluzzi, Matthew R. Redinbo, Adam P. Matson, Bret D. Wallace, Gary H. Perdew, Martina Stepankova, Ryan Balfour Sartor, Eva Jiskrová, Saraswathi Vishveshwara, Shirshendu Chatterjee, Dennis L. Wright, Zdeněk Dvořák, Haiwei Gu, Kyu Shik Mun, John C. March, Simon A. Hirota, Julia Yue Cui, Katherine Sun, Lars U. Nordstroem, Amanda P. Beck, Iveta Iveta Bartonkov, Aneta Vrzalová, Julius Brtko, Barbora Vyhlídalová, Sridhar Mani, Kyle L. Flannigan, Karolína Poulíková, Felix Kopp, Hao Li, Lucia Toporova, Harmit S. Ranhotra, William G. Walton, Cait M. Costello, Sandhya Kortagere, Aneesh Chandran, Giovanni Lentini, Anjaparavanda P. Naren, Jazmin S. Kemp
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp n/a-n/a (2020)
EMBO Molecular Medicine
EMBO Molecular Medicine
The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that established m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e9267d258ba26f43500c0c8a143511
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
Autor:
Marco Gallo, Simon A. Hirota, K Nieves, Kyle L. Flannigan, Kathy D. McCoy, Michael J. Johnston, Humberto Jijon, Sarah L. Erickson
Background The ability of the intestinal microbiota to influence drug metabolism has been recognized, however the mechanisms through which this occurs remain unexplored. Recent work in germ-free mice showed that conventionalization with specific path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30f0128a70b752852b855e757051ef3
https://europepmc.org/articles/PMC7043649/
https://europepmc.org/articles/PMC7043649/
