Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kyle Kuszpit"'
Autor:
Rouba Kozak, Tamás Kiss, Keith Dlugolenski, David E. Johnson, Roxanne R. Gorczyca, Kyle Kuszpit, Brian D. Harvey, Polina Stolyar, Stacey J. Sukoff Rizzo, William E. Hoffmann, Dmitri Volfson, Mihaly Hajós, Jennifer E. Davoren, Amanda L. Abbott, Graham V. Williams, Stacy A. Castner, David L. Gray
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Selective activation of dopamine D1 receptors remains a promising pro-cognitive therapeutic strategy awaiting robust clinical investigation. PF-6142 is a key example from a recently disclosed novel series of non-catechol agonists and partial agonists
Externí odkaz:
https://doaj.org/article/0f0c6a051bdf46babdb1a3b0bfe553ab
Autor:
Darci R Smith, Bradley Hollidge, Sharon Daye, Xiankun Zeng, Candace Blancett, Kyle Kuszpit, Thomas Bocan, Jeff W Koehler, Susan Coyne, Tim Minogue, Tara Kenny, Xiaoli Chi, Soojin Yim, Lynn Miller, Connie Schmaljohn, Sina Bavari, Joseph W Golden
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 1, p e0005296 (2017)
Animal models are needed to better understand the pathogenic mechanisms of Zika virus (ZIKV) and to evaluate candidate medical countermeasures. Adult mice infected with ZIKV develop a transient viremia, but do not demonstrate signs of morbidity or mo
Externí odkaz:
https://doaj.org/article/41c1b6ca03d84f3fa1c7ae1fc97f533f
Autor:
James G. Christensen, Kenna Anderes, Ming Qiu, Guizhen Sun, Dana Buckman, Anthony Wong, Jill Hallin, Max Hallin, Kenneth Zasadny, Kyle Kuszpit, Maria E. Arango, Enhong Chen, Qin Zhang, Cory L. Painter, Zhengming Yan, Cathy Zhang
Purpose: Checkpoint kinase 1 (Chk1) plays a critical role in the activation of mitotic spindle checkpoint and DNA damage checkpoint. We examined the preclinical use of the Chk1 inhibitor PF-00477736 as a docetaxel-sensitizing agent. Specifically, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65662b0ccd3f3eafbfc7b3755e2a464b
https://doi.org/10.1158/1078-0432.c.6517585
https://doi.org/10.1158/1078-0432.c.6517585
Autor:
Todd VanArsdale, James G. Christensen, Kenna Anderes, Steve Bender, Gerrit Los, Gerald F. Casperson, Ian Popoff, Pramod P. Mehta, Maria E. Arango, Eugenia Kraynov, Anthony Wong, Cory L. Painter, Ming Qiu, Kenneth Zasadny, Kyle Kuszpit, Qin Zhang, Zhengming Yan, Cathy C. Zhang
Supplementary Figures 1 - 5 from PF-03732010: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5716abf629002f9572c1aabb8d4b5f32
https://doi.org/10.1158/1078-0432.22442942
https://doi.org/10.1158/1078-0432.22442942
Autor:
James G. Christensen, Anthony Wong, Dana Buckman, Peter O'Brien, Kenneth Zasadny, Mary Spilker, Carleen Cullinane, Neeta R. Fahey, Timothy Affolter, Maruja E. Lira, Tim Nichols, Patrick B. Lappin, Qin Zhang, Cory L. Painter, Kyle Kuszpit, Wenlin Li, Zhengming Yan, Cathy C. Zhang
CCR Translation for This Article from [18F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96968392700e4f56dcc13cde90952e86
https://doi.org/10.1158/1078-0432.22444500
https://doi.org/10.1158/1078-0432.22444500
Autor:
Todd VanArsdale, James G. Christensen, Kenna Anderes, Steve Bender, Gerrit Los, Gerald F. Casperson, Ian Popoff, Pramod P. Mehta, Maria E. Arango, Eugenia Kraynov, Anthony Wong, Cory L. Painter, Ming Qiu, Kenneth Zasadny, Kyle Kuszpit, Qin Zhang, Zhengming Yan, Cathy C. Zhang
Purpose: P-cadherin is a membrane glycoprotein that functionally mediates tumor cell adhesion, proliferation, and invasiveness. We characterized the biological properties of PF-03732010, a human monoclonal antibody against P-cadherin, in cell-based a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749c196be50ef782d8f3ce7b2d11a05e
https://doi.org/10.1158/1078-0432.c.6519563.v1
https://doi.org/10.1158/1078-0432.c.6519563.v1
Autor:
James G. Christensen, Kenna Anderes, Ming Qiu, Guizhen Sun, Dana Buckman, Anthony Wong, Jill Hallin, Max Hallin, Kenneth Zasadny, Kyle Kuszpit, Maria E. Arango, Enhong Chen, Qin Zhang, Cory L. Painter, Zhengming Yan, Cathy Zhang
Supplementary Data from PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63056040a1c2a7d6e63ef995538d6aba
https://doi.org/10.1158/1078-0432.22440235
https://doi.org/10.1158/1078-0432.22440235
Autor:
James G. Christensen, Anthony Wong, Dana Buckman, Peter O'Brien, Kenneth Zasadny, Mary Spilker, Carleen Cullinane, Neeta R. Fahey, Timothy Affolter, Maruja E. Lira, Tim Nichols, Patrick B. Lappin, Qin Zhang, Cory L. Painter, Kyle Kuszpit, Wenlin Li, Zhengming Yan, Cathy C. Zhang
Purpose: [18F]FLT (3′-Fluoro-3′ deoxythymidine)–PET imaging was proposed as a tool for measuring in vivo tumor cell proliferation. The aim of this article was to validate the use of [18F]FLT–PET imaging for measuring xenograft proliferation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1e7e14da69a2c102f14c5e07ac9966
https://doi.org/10.1158/1078-0432.c.6520203.v1
https://doi.org/10.1158/1078-0432.c.6520203.v1
Autor:
James G. Christensen, Anthony Wong, Dana Buckman, Peter O'Brien, Kenneth Zasadny, Mary Spilker, Carleen Cullinane, Neeta R. Fahey, Timothy Affolter, Maruja E. Lira, Tim Nichols, Patrick B. Lappin, Qin Zhang, Cory L. Painter, Kyle Kuszpit, Wenlin Li, Zhengming Yan, Cathy C. Zhang
PDF file - 77K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb4a2d7a0567a63c068a952cf3da7db
https://doi.org/10.1158/1078-0432.22444497
https://doi.org/10.1158/1078-0432.22444497
Autor:
Mark A Sellmyer, Iris K Lee, Kyle Kuszpit, Jyoti Roy, Alex Alfaro, Virginie Ory, Lily Cheng, Daniel Sutton, Emily Bosco, Christine Fazenbaker, Shabazz Novarra, Ryan Gilbreth, Nick Tschernia, Deborah Berry, Xiaoru Chen, Yuling Wu, Ryan Wong
Publikováno v:
Cancer Immunology Research. 10:A37-A37
Genetically engineered medicines such as chimeric antigen receptor (CAR) T cells have great potential to be the next pillar of medical therapy beyond chemo- and traditional biologic therapies. To develop genetic medicines, new methods to understand t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb77f0ee9e7dfe246b7eac19038aa71
https://doi.org/10.1158/2326-6074.tumimm22-a37
https://doi.org/10.1158/2326-6074.tumimm22-a37