Výsledky vyhledávání - "Kyle J. Nakamura"

Unique genotypic features of HIV-1 C gp41 membrane proximal external region variants during pregnancy relate to mother-to-child transmission via breastfeeding

Autor: Louise Kuhn, Grace M. Aldrovandi, Kyle J. Nakamura, Li Yin, Maureen M. Goodenow, Kai-Fen Chang

Publikováno v: Journal of clinical pediatrics and neonatology
Journal of clinical pediatrics and neonatology, vol 1, iss 1

Mother-to-child transmission (MTCT) through breastfeeding remains a major source of pediatric HIV-1 infection worldwide. To characterize plasma HIV-1 subtype C populations from infected mothers during pregnancy that related to subsequent breast milk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08aaab5b6f3ddae39fd0a67416b4bb2
https://pubmed.ncbi.nlm.nih.gov/34553192

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Akademický článek

A Conserved Glycan in the C2 Domain of HIV-1 Envelope Acts as a Molecular Switch to Control X4 Utilization by Clonal Variants with Identical V3 Loops.

Autor: Francesca Lombardi, Kyle J Nakamura, Thomas Chen, Edwin R Sobrera, Nicole H Tobin, Grace M Aldrovandi

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0128116 (2015)

Nearly all persons newly infected with HIV-1 harbor exclusively CCR5-using virus. CXCR4-using variants eventually arise in up to 50% of patients infected with subtypes B or D. This transition to efficient CXCR4 utilization is often co-incident with p

Externí odkaz: https://doaj.org/article/51ab23ca3e1b452fa226431e534cf3c8

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Akademický článek

4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms.

Autor: Kyle J Nakamura, Johannes S Gach, Laura Jones, Katherine Semrau, Jan Walter, Frederic Bibollet-Ruche, Julie M Decker, Laura Heath, William D Decker, Moses Sinkala, Chipepo Kankasa, Donald Thea, James Mullins, Louise Kuhn, Michael B Zwick, Grace M Aldrovandi

Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9786 (2010)

Human antibody 4E10 targets the highly conserved membrane-proximal external region (MPER) of the HIV-1 transmembrane glycoprotein, gp41, and has extraordinarily broad neutralizing activity. It is considered by many to be a prototype for vaccine devel

Externí odkaz: https://doaj.org/article/e38757135abe4c1594c7b6074c0a896f

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Breast milk and in utero transmission of HIV-1 select for envelope variants with unique molecular signatures

Autor: Laura Heath, Thomas A. Wilkinson, Nicholas E. Webb, Louise Kuhn, Grace M. Aldrovandi, Kyle J. Nakamura, Nicole H. Tobin, Edwin R. Sobrera, Benhur Lee, Donald M. Thea, Katherine Semrau, Chipepo Kankasa, James I. Mullins

Publikováno v: Retrovirology, vol 14, iss 1
Retrovirology

Background Mother-to-child transmission of human immunodeficiency virus-type 1 (HIV-1) poses a serious health threat in developing countries, and adequate interventions are as yet unrealized. HIV-1 infection is frequently initiated by a single founde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e4f6f862f48f292f32204af7d12c2a
https://escholarship.org/uc/item/95m5w5ks

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Intrapartum Tenofovir and Emtricitabine Reduces Low-Concentration Drug Resistance Selected by Single-Dose Nevirapine for Perinatal HIV Prevention

Autor: Elizabeth M. Stringer, Ronald A. Cantrell, Ranjit Warrier, Giovanina M. Ellis, Benjamin H. Chi, Kyle J. Nakamura, Felistas Mbewe, Moses Sinkala, Namwinga Chintu, Jeffrey S. A. Stringer, Grace M. Aldrovandi, Lisa M. Frenkel

Publikováno v: AIDS Research and Human Retroviruses. 25:1099-1106

A single dose of tenofovir/emtricitabine (TDF/FTC) during labor significantly reduces peripartum nevirapine-associated viral drug resistance when measured by consensus HIV sequencing. It is unknown whether this effect extends to HIV subpopulations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a275505adc67caa26feb7540b69c8ee
https://doi.org/10.1089/aid.2009.0088

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Coverage of primary mother-to-child HIV transmission isolates by second-generation broadly neutralizing antibodies

Autor: James I. Mullins, Grace M. Aldrovandi, Chiara Cerini, Louise Kuhn, Moses Sinkala, Edwin R. Sobrera, Chipepo Kankasa, Laura Heath, Kyle J. Nakamura, Donald M. Thea

Publikováno v: AIDS (London, England). 27(3)

Objectives and design: A vaccine capable of providing cross-clade, sterilizing protection has been the holy grail of HIV-1 prevention and control since the beginning of the pandemic. A major component of this effort has been the identification and ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e638b58a47545d57a7613222e70b725
https://pubmed.ncbi.nlm.nih.gov/23296195

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Multiple independent lineages of HIV-1 persist in breast milk and plasma

Autor: Marco Salemi, Moses Sinkala, Louise Kuhn, William D. Decker, Kyle J. Nakamura, Amanda C Lowe, Donald M. Thea, Rebecca R. Gray, Maureen M. Goodenow, Chipepo Kankasa, Grace M. Aldrovandi, Connie J. Mulligan

Publikováno v: AIDS (London, England). 25(2)

DESIGN: the origin and evolution of HIV-1 in breast milk is unclear, despite the continuing significance of this tissue as a transmitting compartment. To elucidate the evolutionary trajectory of viral populations in a transient mucosal compartment, l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f52879e872b8006509657dee81eb949
http://ora.ox.ac.uk/objects/uuid:469db690-4dec-48f4-9024-09930aba0ac1

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Restriction of HIV-1 genotypes in breast milk does not account for the population transmission genetic bottleneck that occurs following transmission

Autor: Chipepo Kankasa, Laura Jones, Kyle J. Nakamura, Donald M. Thea, James I. Mullins, Katherine Semrau, Jason Hong, W. Don Decker, Moses Sinkala, Laura Heath, Grace M. Aldrovandi, Louise Kuhn, Thomas C. Chen, Marintha L. Heil, Susan E. Conway, Jan Walter

Publikováno v: PLoS ONE, Vol 5, Iss 4, p e10213 (2010)
PLoS ONE

Background Breast milk transmission of HIV-1 remains a major route of pediatric infection. Defining the characteristics of viral variants to which breastfeeding infants are exposed is important for understanding the genetic bottleneck that occurs in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24cf2eaceebe38df89d8e4c93668d68
http://europepmc.org/articles/PMC2857876?pdf=render

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4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms

Autor: Grace M. Aldrovandi, Chipepo Kankasa, Frederic Bibollet-Ruche, Katherine Semrau, Michael B. Zwick, Louise Kuhn, Kyle J. Nakamura, Laura Heath, Johannes S. Gach, Julie M. Decker, Jan Walter, James I. Mullins, William D. Decker, Donald M. Thea, Laura Jones, Moses Sinkala

Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9786 (2010)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf55987f494da172bcbc55a20e3c8211
http://europepmc.org/articles/PMC2843716?pdf=render

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Deep sequencing reveals an association between HIV-1 subtype C mutations in gp41 MPER epitopes and mother-to-child transmission

Autor: Chipepo Kankasa, Kyle J. Nakamura, Wei Hou, Maureen M. Goodenow, Grace M. Aldrovandi, Louise Kuhn, Brent P Gardner, Yunpeng Cai, Moses Sinkala, Donald M. Thea, Li Yin, Kai-Fen Chang

Publikováno v: Retrovirology
Retrovirology, Vol 9, Iss Suppl 2, p P154 (2012)

Methods Pyrosequences of HIV-1 subtype-C gp41 heptad repeatregion 2 (HR2), MPER, and membrane-spanning domain (MSD) were generated from 2,000 plasma viral copies/subject from four mothers who transmitted via breast feeding (TM) and four non-transmitt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d2e9ca664a18d1b06e2bf9569758a5
http://europepmc.org/articles/PMC3441794

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