Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kyle J. Horning"'
Autor:
Katie R. Sullivan, Sarah M. Ruggiero, Julie Xian, Kim M. Thalwitzer, Rahma Ali, Sydni Stewart, Mahgenn Cosico, Jackie Steinberg, James Goss, Anna C. Pfalzer, Kyle J. Horning, Nicole Weitzel, Sydney Corey, Laura Conway, Charlene Son Rigby, Terry Jo Bichell, Ingo Helbig
Publikováno v:
Epilepsia Open, Vol 8, Iss 2, Pp 320-333 (2023)
Abstract Objective STXBP1‐related disorders are rare genetic epilepsies and neurodevelopmental disorders, but the impact of symptoms across clinical domains is poorly understood. Disease concept models are formal frameworks to assess the lived expe
Externí odkaz:
https://doaj.org/article/8198dab77bef450281e40e20c2430f6a
Autor:
Sanjana Kalvakuntla, MinJae Lee, Wendy K. Chung, Scott Demarest, Amber Freed, Kyle J. Horning, Terry Jo Bichell, Susan T. Iannaccone, Kimberly Goodspeed
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionSLC6A1-related disorder is a genetic neurodevelopmental disorder that is caused by loss of function variants in the SLC6A1 gene. Solute Carrier Family 6 Member 1 (SLC6A1) gene encodes for gamma-aminobutyric acid (GABA) transporter type 1
Externí odkaz:
https://doaj.org/article/5ddf0bcd9f754f219dbeedef88f64c30
Autor:
Lillian J. Juttukonda, William N. Beavers, Daisy Unsihuay, Kwangho Kim, Gleb Pishchany, Kyle J. Horning, Andy Weiss, Hassan Al-Tameemi, Jeffrey M. Boyd, Gary A. Sulikowski, Aaron B. Bowman, Eric P. Skaar
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Metals are essential nutrients that all living organisms acquire from their environment. While metals are necessary for life, excess metal uptake can be toxic; therefore, intracellular metal levels are tightly regulated in bacterial cells. S
Externí odkaz:
https://doaj.org/article/1260e5a12a7c4059be846aa784f59aa4
Publikováno v:
Molecules, Vol 26, Iss 4, p 1175 (2021)
Manganese (Mn) is a biologically essential metal, critical as a cofactor for numerous enzymes such a glutamine synthetase and kinases such as ataxia-telangiectasia mutated (ATM). Similar to other essential metals such as iron and zinc, proper levels
Externí odkaz:
https://doaj.org/article/62f60a0b8a3f4b4f993972c880c59248
Autor:
Katie R Sullivan, Sarah M Ruggiero, Julie Xian, Kim M Thalwitzer, Sydni Stewart, Mahgenn Cosico, Jackie Steinberg, James Goss, Anna Pfalzer, Kyle J Horning, Nicole Weitzel, Sydney Corey, Laura Conway, Charlene Son Rigby, Terry Jo Bichell, Ingo Helbig
ObjectiveSTXBP1-related disorders are common genetic epilepsies and neurodevelopmental disorders, but the impact of symptoms across clinical domains is poorly understood. Disease concept models are formal frameworks to assess the lived experience of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cd2ad2c972f74fffe9b2f16ab8b745c
https://doi.org/10.1101/2022.08.05.22278197
https://doi.org/10.1101/2022.08.05.22278197
Autor:
Daisy Unsihuay, Gleb Pishchany, Eric P. Skaar, Kwangho Kim, Andy Weiss, Gary A. Sulikowski, Lillian J. Juttukonda, William N. Beavers, Kyle J. Horning, Hassan Al-Tameemi, Jeffrey M. Boyd, Aaron B. Bowman
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
mBio
mBio
Staphylococcus aureus is a leading agent of antibiotic-resistant bacterial infections in the world. S. aureus tightly controls metal homeostasis during infection, and disruption of metal uptake systems impairs staphylococcal virulence. We identified
Publikováno v:
Journal of Neurochemistry. 143:171-182
Adrenal chromaffin cells (ACCs) are the neuroendocrine arm of the sympathetic nervous system and key mediators of the physiological stress response. Acetylcholine (ACh) released from preganglionic splanchnic nerves activates nicotinic acetylcholine r
Autor:
Plamen P. Christov, Gary A. Sulikowski, C. David Weaver, Kyle J. Horning, Rekha C. Balachandran, Michael Aschner, Frank M. Yanko, Rachana Nitin, Aaron B. Bowman, Piyush Joshi, Kwangho Kim
Publikováno v:
J Biol Chem
Available assays for measuring cellular manganese (Mn) levels require cell lysis, restricting longitudinal experiments and multiplexed outcome measures. Conducting a screen of small molecules known to alter cellular Mn levels, we report here that one
Publikováno v:
Journal of Neurochemistry. 136:804-814
The kynurenine pathway (KP), the major catabolic route of the essential amino acid l-tryptophan (l-TRP), contains several neuroactive compounds, including kynurenic acid, 3-hydroxykynurenine (3-HK), and quinolinic acid (QUIN). The role of the d-enant
Autor:
Julia Bornhorst, Tanja Schwerdtle, Michael Aschner, Kyle J. Horning, Tanara V. Peres, Aaron B. Bowman
Manganese (Mn) is essential for several species and daily requirements are commonly met by an adequate diet. Mn overload may cause motor and psychiatric disturbances and may arise from an impaired or not fully developed excretion system, transporter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540a05d0516d581074f5bb1af44a13d5
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/50094
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/50094