Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kyle J. Card"'
Publikováno v:
Antibiotics, Vol 11, Iss 3, p 347 (2022)
Antibiotic resistance is a growing concern that has prompted a renewed focus on drug discovery, stewardship, and evolutionary studies of the patterns and processes that underlie this phenomenon. A resistant strain’s competitive fitness relative to
Externí odkaz:
https://doaj.org/article/4458ac502b6a4979a472f9f559bc9853
Autor:
Vishhvaan Gopalakrishnan, Dena Crozier, Kyle J Card, Lacy D Chick, Nikhil P Krishnan, Erin McClure, Julia Pelesko, Drew FK Williamson, Daniel Nichol, Soumyajit Mandal, Robert A Bonomo, Jacob G Scott
Publikováno v:
eLife, Vol 11 (2022)
A morbidostat is a bioreactor that uses antibiotics to control the growth of bacteria, making it well-suited for studying the evolution of antibiotic resistance. However, morbidostats are often too expensive to be used in educational settings. Here w
Externí odkaz:
https://doaj.org/article/eea930f7d3fc47c2ac8f031f9dbf8922
Autor:
Davis T Weaver, Benjamin D McElvany, Vishhvaan Gopalakrishnan, Kyle J Card, Dena Crozier, Andrew Dhawan, Mina N Dinh, Emily Dolson, Nathan Farrokhian, Masahiro Hitomi, Emily Ho, Tanush Jagdish, Eshan S King, Jennifer L Cadnum, Curtis J Donskey, Nikhil Krishnan, Gleb Kuzmin, Ju Li, Jeff Maltas, Jinhan Mo, Julia Pelesko, Jessica A Scarborough, Geoff Sedor, Enze Tian, Gary C An, Sean A Diehl, Jacob G Scott
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0241734 (2021)
Personal protective equipment (PPE) is crucially important to the safety of both patients and medical personnel, particularly in the event of an infectious pandemic. As the incidence of Coronavirus Disease 2019 (COVID-19) increases exponentially in t
Externí odkaz:
https://doaj.org/article/c9cb9eb3a2b1444ea76753df9db95399
Historical contingency in the evolution of antibiotic resistance after decades of relaxed selection.
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000397 (2019)
Populations often encounter changed environments that remove selection for the maintenance of particular phenotypic traits. The resulting genetic decay of those traits under relaxed selection reduces an organism's fitness in its prior environment. Ho
Externí odkaz:
https://doaj.org/article/53fed29e0c39435b8f67d2d2bd140f78
Autor:
Kyle J Card, Dena Crozier, Vishhvaan Gopalakrishnan, Lacy D Chick, Nikhil P Krishnan, Erin McClure, Julia Pelesko, Drew FK Williamson, Daniel Nichol, Soumyajit Mandal, Robert A Bonomo, Jacob G Scott
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b7cc7a92546bf990d865c09a9048dd3
https://doi.org/10.7554/elife.83067.sa2
https://doi.org/10.7554/elife.83067.sa2
Publikováno v:
Proc Natl Acad Sci U S A
Antibiotic resistance is a growing health concern. Efforts to control resistance would benefit from an improved ability to forecast when and how it will evolve. Epistatic interactions between mutations can promote divergent evolutionary trajectories,
Autor:
Ju Li, Masahiro Hitomi, Nikhil Krishnan, Kyle J. Card, Dena Crozier, Andrew Dhawan, Gleb Kuzmin, Sean A. Diehl, Vishhvaan Gopalakrishnan, Jennifer L. Cadnum, Jacob G. Scott, Jeff Maltas, Gary An, Curtis J. Donskey, Davis T. Weaver, Julia Pelesko, Jessica A. Scarborough, Tanush Jagdish, Nathan Farrokhian, Benjamin D. McElvany, Emily Dolson, Enze Tian, Geoff Sedor, Emily Ho, Mina N. Dinh, Jinhan Mo, Eshan S. King
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0241734 (2021)
PLoS ONE
PLoS ONE
Personal protective equipment (PPE) is crucially important to the safety of both patients and medical personnel, particularly in the event of an infectious pandemic. As the incidence of Coronavirus Disease 2019 (COVID-19) increases exponentially in t
Idiosyncratic variation in the fitness costs of tetracycline-resistance mutations inEscherichia coli
A bacterium’s fitness relative to its competitors, both in the presence and absence of antibiotics, plays a key role in its ecological success and clinical impact. In this study, we examine whether tetracycline-resistant mutants are less fit in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8999c92cc025c3bf82739f6c5327ac60
https://doi.org/10.1101/2020.09.12.294355
https://doi.org/10.1101/2020.09.12.294355
Antibiotic resistance is a growing health concern. Efforts to control resistance would benefit from an improved ability to forecast when and how it will evolve. Epistatic interactions between mutations can promote divergent evolutionary trajectories,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5f9f0c50a0157e29ab6faf5c0f9930
https://doi.org/10.1101/2020.08.19.258384
https://doi.org/10.1101/2020.08.19.258384
Autor:
Gary An, Benjamin D. McElvany, Eshan S. King, Sean A. Diehl, Dena Crozier, Masahiro Hitomi, Vishhvaan Gopalakrishnan, Mina N. Dinh, Davis T. Weaver, Nathan Farrokhian, Kyle J. Card, Jessica A. Scarborough, Jinhan Mo, Julia Pelesko, Jeff Maltas, Jacob G. Scott, Emily Ho, Nikhil Krishnan, Andrew Dhawan, Tanush Jagdish, Ju Li, Geoff Sedor, Gleb Kuzmin, Enze Tian, Emily Dolson
DISCLAIMERThis article does not represent the official recommendation of the Cleveland Clinic or Case Western Reserve University School of Medicine, nor has it yet been peer reviewed. We are releasing it early, pre-peer review, to allow for quick dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dde4acbb206c6aa8b53bae27d5f626d