Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kyle Gilmour"'
Autor:
Emma J. Crosbie, Henry C. Kitchener, W. David Ryder, Joseph Shaw, Philip W. Pemberton, Richard J. Slade, Rahamatulla Latheef, Kyle Gilmour, Sean Burns, Saad Ali, Jennifer L. Allen, Vanitha N. Sivalingam, Zoe Maskell, Sarah J. Kitson
Immunohistochemistry staining protocols
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ab8694cf7bee89d7f1ca48ac3f3d42
https://doi.org/10.1158/1078-0432.22471361.v1
https://doi.org/10.1158/1078-0432.22471361.v1
Autor:
Emma J. Crosbie, Henry C. Kitchener, W. David Ryder, Joseph Shaw, Philip W. Pemberton, Richard J. Slade, Rahamatulla Latheef, Kyle Gilmour, Sean Burns, Saad Ali, Jennifer L. Allen, Vanitha N. Sivalingam, Zoe Maskell, Sarah J. Kitson
Supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aedb79883eeb151c50db31289da530e
https://doi.org/10.1158/1078-0432.22471364
https://doi.org/10.1158/1078-0432.22471364
Autor:
Emma J. Crosbie, Henry C. Kitchener, W. David Ryder, Joseph Shaw, Philip W. Pemberton, Richard J. Slade, Rahamatulla Latheef, Kyle Gilmour, Sean Burns, Saad Ali, Jennifer L. Allen, Vanitha N. Sivalingam, Zoe Maskell, Sarah J. Kitson
Purpose:Endometrioid endometrial cancer is strongly associated with obesity and insulin resistance. Metformin, an insulin sensitizer, reduces endometrial tumor growth in vitro. Presurgical window studies allow rapid in vivo assessment of antitumor ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0a0625798f85b0fada3a1fc80da235
https://doi.org/10.1158/1078-0432.c.6527864.v1
https://doi.org/10.1158/1078-0432.c.6527864.v1
Autor:
Sarah J, Kitson, Zoe, Maskell, Vanitha N, Sivalingam, Jennifer L, Allen, Saad, Ali, Sean, Burns, Kyle, Gilmour, Rahamatulla, Latheef, Richard J, Slade, Philip W, Pemberton, Joseph, Shaw, W David, Ryder, Henry C, Kitchener, Emma J, Crosbie
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(8)
PURPOSE: Endometrioid endometrial cancer is strongly associated with obesity and insulin resistance. Metformin,an insulin sensitizer, reduces endometrial tumor growth in vitro. Presurgical window studies allow rapid in vivo assessment of antitumor ac
Autor:
Philip W. Pemberton, Kyle Gilmour, Emma J Crosbie, Henry C Kitchener, Andrew G Renehan, Sarah Kitson, Chris Roberts, Rhona J McVey, Vanitha N Sivalingam, S Ali
Publikováno v:
British Journal of Cancer
Sivalingam, V N, Kitson, S, McVey, R, Roberts, C, Pemberton, P, Gilmour, K, Ali, S, Renehan, A G, Kitchener, H C & Crosbie, E J 2016, ' Measuring the biological effect of presurgical metformin treatment in endometrial cancer ', British Journal of Cancer, vol. 114, no. 3, pp. 281-289 . https://doi.org/10.1038/bjc.2015.453
Sivalingam, V N, Kitson, S, McVey, R, Roberts, C, Pemberton, P, Gilmour, K, Ali, S, Renehan, A G, Kitchener, H C & Crosbie, E J 2016, ' Measuring the biological effect of presurgical metformin treatment in endometrial cancer ', British Journal of Cancer, vol. 114, no. 3, pp. 281-289 . https://doi.org/10.1038/bjc.2015.453
BACKGROUND: Preclinical studies in endometrial cancer (EC) show that metformin reduces cellular proliferation by PI3K-AKT-mTOR inhibition. We tested the hypothesis that short-term presurgical metformin reduces cellular proliferation in atypical endom
Autor:
Joseph Shaw, Sarah Kitson, Richard J Slade, Rahamatulla Latheef, Saad Ali, Henry C Kitchener, Jennifer L. Allen, Vanitha N Sivalingam, Sean Burns, Emma J Crosbie, Phil Pemberton, Kyle Gilmour, W David J Ryder, Zoe Maskell
Publikováno v:
SSRN Electronic Journal.
Background: Endometrial cancer is strongly associated with obesity and insulin resistance. Metformin, an insulin sensitizer, reduces endometrial tumour growth in vitro. Pre-surgical window studies allow rapid in vivo assessment of anti-tumour activit
Autor:
Nicola Cherry, Max Elstein, Kyle Gilmour, Henry C Kitchener, Roseanne McNamee, Esprit team, Anthony M. Heagerty, Mohammed Khan, Clifford R. Kay, Philip C Hannaford, Mourad W. Seif, Hilary Buckley
Publikováno v:
The Lancet. 360:2001-2008
Summary Background Results of observational studies suggest that hormone replacement therapy (HRT) could reduce the risk of coronary heart disease (CHD), but those of randomised trials do not indicate a lower risk in women who use oestrogen plus prog
Autor:
Andrew G Renehan, Vanitha N Sivalingam, Henry C Kitchener, Rhona J McVey, Emma J Crosbie, Chris Roberts, Sarah Kitson, S Ali, Kyle Gilmour
Publikováno v:
Gynecologic Oncology. 137:18
population was significantly more dormant than the original tumor. RNA sequencing analysis of treated and untreated PDX tumors (n = 6 pair) demonstrated that numerous factors with roles in ribosomal synthesis were significantly altered by treatment.
Autor:
Vanitha N Sivalingam, Henry C Kitchener, Andrew G Renehan, Chris Roberts, Kyle Gilmour, Rhona J McVey, Emma J Crosbie, S Ali
Publikováno v:
Sivalingam, V, McVey, R, Gilmour, K, Ali, S, Roberts, C, Renehan, A, Kitchener, H & Crosbie, E 2015, ' A presurgical window-of-opportunity study of metformin in obesity-driven endometrial cancer ', The Lancet, vol. 385, no. S90 . https://doi.org/10.1016/S0140-6736(15)60405-6
BACKGROUND: Metformin use is associated with reduced cancer risk in several observational studies of patients with type 2 diabetes. Results from preclinical studies in endometrial cancer show that metformin reduces cellular proliferation by inhibitio