Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kyle Denton"'
Publikováno v:
Neurobiology of Disease, Vol 91, Iss , Pp 182-193 (2016)
Mounting evidence suggests that epigenetic modifications play critical roles in the survival/death of stressed neurons. Chief among these modifications is the deacetylation of histones within the chromatin by histone deacetylases (HDACs). HDAC4 is hi
Externí odkaz:
https://doaj.org/article/36a62f957ff04a04b349a09611d2843e
Publikováno v:
Cell reports
SUMMARY Lethal drugs can induce incomplete cell death in a population of cancer cells, a phenomenon referred to as fractional killing. Here, we show that high-throughput population-level time-lapse imaging can be used to quantify fractional killing i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d4dfe0ca8bf87040c960479bd1e58d
http://europepmc.org/articles/PMC7409774
http://europepmc.org/articles/PMC7409774
Autor:
Andrew D. Ferguson, Usha Narayanan, Christelle Huguet, John P Giulinger, Michael I Monteiro, Matthew A. Clark, Chris Hupp, Mortiz Von Rechenberg, Andrew J. McRiner, Kyle Denton, Anthony D. Keefe, John W. Cuozzo, Shilpi Arora, Sarah A Talcott, Diana Gikunju
Publikováno v:
Molecular Cancer Therapeutics. 18:C049-C049
K-Ras is the most frequently mutated oncogene in cancer. Most mutations cluster in codons 12, 13 and 61, and are involved in the development and progression of a wide range of cancers. Drugging K-Ras has been challenging using traditional drug discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::264ca8cf52f2cf4205d1dd345f561dce
https://doi.org/10.1158/1535-7163.targ-19-c049
https://doi.org/10.1158/1535-7163.targ-19-c049
Autor:
April Herleikson, Albee Y. Ling, Alexis Carlson, Thomas Carroll, Daniel Ellowitz, Katrina Yearwood, Morgan M. Atkinson, Rachel Gore, Heather A. Wiatrowski, Piangfan Naksukpaiboon, Andrea Gialtouridis, Rachael Martin, Audrey Seiz, Kristen Cullity, Katherine McMahan, Kyle Denton, Stacey P. Borenstein, Casey DeMarsico, James O’Neill
Publikováno v:
Archives of Microbiology. 195:661-670
Denitrovibrio acetiphilus N2460(T) is one of the few members of the phylum Deferribacteres with a sequenced genome. N2460(T) was capable of growing with dimethyl sulfoxide, selenate, or arsenate provided as a terminal electron acceptor, and we identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9adb5b1fcc276cf24f431d33b0eda22
https://doi.org/10.1007/s00203-013-0915-5
https://doi.org/10.1007/s00203-013-0915-5
Publikováno v:
Stroke. 46
HDAC4 has been identified as a transcriptional corepressor that catalyzes local histone deacetylation. It is highly expressed in neurons and usually trapped in cytosol. In vitro, translocation of HDAC4 from cytosol into nucleus induced neuronal death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0f923a51cb39a3beb3b42a1b3fd2491
https://doi.org/10.1161/str.46.suppl_1.113
https://doi.org/10.1161/str.46.suppl_1.113
Publikováno v:
Stroke. 46
Background: CaMKK β is a major kinase activated by elevated levels of intracellular calcium. Our previous data has suggested that CaMKK β is neuroprotective after stroke in young mice as inhibition of this kinase aggravated stroke outcome. As aging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71cb0be88e569998e8aa2724d33fa770
https://doi.org/10.1161/str.46.suppl_1.29
https://doi.org/10.1161/str.46.suppl_1.29