Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kyle Dent"'
Publikováno v:
Temes de Disseny, Iss 35 (2019)
As machine learning and AI systems gain greater capabilities and are deployed more widely, we – as designers, developers, and researchers – must consider both the positive and negative implications of their use. In light of this, PARC’s researc
Externí odkaz:
https://doaj.org/article/8f3584407f4842fe92448371b8eba6c3
Autor:
Vasileios Kargas, Pablo Castro-Hartmann, Norberto Escudero-Urquijo, Kyle Dent, Christine Hilcenko, Carolin Sailer, Gertrude Zisser, Maria J Marques-Carvalho, Simone Pellegrino, Leszek Wawiórka, Stefan MV Freund, Jane L Wagstaff, Antonina Andreeva, Alexandre Faille, Edwin Chen, Florian Stengel, Helmut Bergler, Alan John Warren
Publikováno v:
eLife, Vol 8 (2019)
During their final maturation in the cytoplasm, pre-60S ribosomal particles are converted to translation-competent large ribosomal subunits. Here, we present the mechanism of peptidyltransferase centre (PTC) completion that explains how integration o
Externí odkaz:
https://doaj.org/article/68e853793d0c4ab19d7cce1b81cf73da
Autor:
Leonor Miller-Fleming, Van Haute L, Rogan Jf, Adam M. Dinan, Andrew E. Firth, Alan J. Warren, Alexander J. Whitworth, Simone Pellegrino, Pedro Rebelo-Guiomar, Schraga Schwartz, Kyle Dent, Michal Minczuk, Sas Chen A, Caterina Garone, Byron Andrews
Funder: Kay Kendall Leukaemia Fund (KKLF); doi: https://doi.org/10.13039/501100000402
Funder: EC | EC Seventh Framework Programm | FP7 People: Marie-Curie Actions (FP7-PEOPLE - Specific Programme "People" Implementing the Seventh Framework Progr
Funder: EC | EC Seventh Framework Programm | FP7 People: Marie-Curie Actions (FP7-PEOPLE - Specific Programme "People" Implementing the Seventh Framework Progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f18440471c37b12da7c1a0d1c0ea4fb
https://www.repository.cam.ac.uk/handle/1810/334157
https://www.repository.cam.ac.uk/handle/1810/334157
Autor:
Long-Fei Wu, Kasim Sader, Pablo Castro-Hartmann, Jan Löwe, Kyle W. Muir, Pu Qian, Dari Kimanius, Francesca Coscia, Kyle Dent, John D. Sutherland, Christopher J. Russo, M. J. Peet, David Barford, Katerina Naydenova, Ziguo Zhang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
Significance While the current COVID-19 pandemic continues, the US Food and Drug Administration (FDA) has approved only one drug against the virus—remdesivir. It is a nucleotide analogue inhibitor of the SARS-CoV-2 RNA-dependent RNA polymerase; fav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e21905789c96124d65b476169d06d7
https://pubmed.ncbi.nlm.nih.gov/33526596
https://pubmed.ncbi.nlm.nih.gov/33526596
Autor:
Francesca Coscia, Kyle W. Muir, Kyle Dent, Katerina Naydenova, M. J. Peet, Ziguo Zhang, Long-Fei Wu, Pu Qian, Christopher J. Russo, John D. Sutherland, Jan Löwe, Pablo Castro-Hartmann, Dari Kimanius, Kasim Sader, David Barford
The RNA polymerase inhibitor, favipiravir, is currently in clinical trials as a treatment for infection with SARS-CoV-2, despite limited information about the molecular basis for its activity. Here we report the structure of favipiravir ribonucleosid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d78e6eb8467a3da2960d030509851603
https://doi.org/10.1101/2020.10.21.347690
https://doi.org/10.1101/2020.10.21.347690
Autor:
Elizabeth Duke, Ewelina Kosior, Michele C. Darrow, Matthew C. Spink, Kyle Dent, Maria Harkiolaki
Publikováno v:
Emerging Topics in Life Sciences
Cryo-soft X-ray tomography is an imaging technique that addresses the need for mesoscale imaging of cellular ultrastructure of relatively thick samples without the need for staining or chemical modification. It allows the imaging of cellular ultrastr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47957b8833650b8aa6189a0588fcbd07
http://europepmc.org/articles/PMC7289011
http://europepmc.org/articles/PMC7289011
Autor:
Christine Hilcenko, Alan J. Warren, Pablo Castro-Hartmann, Florian Stengel, Stefan M.V. Freund, Norberto Escudero-Urquijo, Antonina Andreeva, Jane L. Wagstaff, Vasileios Kargas, Maria J Marques-Carvalho, Kyle Dent, Carolin Sailer, Alexandre Faille, Edwin Chen, Leszek Wawiórka, Simone Pellegrino, Gertrude Zisser, Helmut Bergler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ca3187fe8c943974e0464c6a62698ab
https://doi.org/10.7554/elife.44904.062
https://doi.org/10.7554/elife.44904.062
Autor:
Pablo Castro-Hartmann, Jane L. Wagstaff, Stefan M.V. Freund, Helmut Bergler, Carolin Sailer, Vasileios Kargas, Edwin Chen, Simone Pellegrino, Alan J. Warren, Florian Stengel, Norberto Escudero-Urquijo, Christine Hilcenko, Leszek Wawiórka, Alexandre Faille, Antonina Andreeva, Kyle Dent, Maria J Marques-Carvalho, Gertrude Zisser
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
During their final maturation in the cytoplasm, pre-60S ribosomal particles are converted to translation-competent large ribosomal subunits. Here, we present the mechanism of peptidyltransferase centre (PTC) completion that explains how integration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a9aecfb5856c5ba154ec1e61b11c0f
http://europepmc.org/articles/PMC6579518
http://europepmc.org/articles/PMC6579518
Publikováno v:
Intelligent Human Systems Integration ISBN: 9783319738871
IHSI
IHSI
Otto is a call center agent designed to help cell phone and mobile provider customers. It has the twin goals of automating call center operations while maintaining a high level of customer satisfaction. It is intended to engage with human users in mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8a6505b9f730181c9f9d666feca3143
https://doi.org/10.1007/978-3-319-73888-8_87
https://doi.org/10.1007/978-3-319-73888-8_87
Autor:
Petra Lukacik, Shabaz Mohammed, Lucia Marti, James Patrick McIvor, Andrea Lia, Abhinav Kumar, Alessandro T. Caputo, Snežana Vasiljević, Kristin Qian, Angelo Santino, Martin A. Walsh, Souradeep Basu, Johan C. Hill, Kyle Dent, Colette B. Lipp, Pietro Roversi, Dritan Siliqi, Mikail D. Levasseur, Dominic S. Alonzi, Thomas Waksman, Yentli Soto Albrecht, Nicole Zitzmann
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 114 (2017): 8544–8549. doi:10.1073/pnas.1703682114
info:cnr-pdr/source/autori:Roversi P.; Marti L.; Caputo A.T.; Alonzi D.S.; Hill J.C.; Dent K.C.; Kumar A.; Levasseur M.D.; Lia A.; Waksman T.; Basu S.; Soto Albrecht Y.; Qian K.; McIvor J.P.; Lipp C.B.; Siliqi D.; Vasiljevic S.; Mohammed S.; Lukacik P.; Walsh M.A.; Santino A.; Zitzmann N./titolo:Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint/doi:10.1073%2Fpnas.1703682114/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2017/pagina_da:8544/pagina_a:8549/intervallo_pagine:8544–8549/volume:114
info:cnr-pdr/source/autori:Roversi P.; Marti L.; Caputo A.T.; Alonzi D.S.; Hill J.C.; Dent K.C.; Kumar A.; Levasseur M.D.; Lia A.; Waksman T.; Basu S.; Soto Albrecht Y.; Qian K.; McIvor J.P.; Lipp C.B.; Siliqi D.; Vasiljevic S.; Mohammed S.; Lukacik P.; Walsh M.A.; Santino A.; Zitzmann N./titolo:Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint/doi:10.1073%2Fpnas.1703682114/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2017/pagina_da:8544/pagina_a:8549/intervallo_pagine:8544–8549/volume:114
Glycoproteins traversing the eukaryotic secretory pathway begin life in the endoplasmic reticulum (ER), where their folding is surveyed by the 170 kDa UDP-glucose:glycoprotein glucosyltransferase (UGGT). The enzyme acts as the single glycoprotein fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a7783e7d55e7e326dc2c215686d665