Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kyle D. Baucom"'
Autor:
Maria Victoria Silva Elipe, Kyle D. Baucom, Derek B. Brown, Kyle Quasdorf, Seb Caille, James I. Murray
Publikováno v:
The Journal of Organic Chemistry. 87:1977-1985
The ipso nitration of aryl boronic acid derivatives has been developed using fuming nitric acid as the nitrating agent. This facile procedure provides efficient and chemoselective access to a variety of aromatic nitro compounds. While several activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9504adeb56930024c90b9a3bb215e45b
https://doi.org/10.1021/acs.joc.1c00886
https://doi.org/10.1021/acs.joc.1c00886
Autor:
Andrew Cosbie, Kyle D. Baucom, Seb Caille, Maria Victoria Silva Elipe, Kyle Quasdorf, James I. Murray
Publikováno v:
Organic Process Research & Development. 24:1523-1530
During development of a radical benzylic bromination, observation of polymerized by-products and variation in isolated yields warranted an in-depth mechanistic investigation to ensure process under...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e780750b6db5113ec6dc2e493925817
https://doi.org/10.1021/acs.oprd.0c00256
https://doi.org/10.1021/acs.oprd.0c00256
Autor:
Jo Anna Robinson, Ayman Allian, Jan Riedel, Michael T. Corbett, Kyle D. Baucom, Wendy Chen, Sheng Cui, Derek B. Brown, Elçin Içten, Parth Patel, Michael A. Lovette, Matthew G. Beaver, Tawnya G. Flick, Alicia Zeng, Xianqing Shi, Ning Yang, Andrew T. Parsons, Shawn D. Walker
Publikováno v:
Organic Process Research & Development. 24:490-499
The development and kilogram-scale demonstration of an improved process for the synthesis of the epoxyketone warhead of carfilzomib is described. Critical to the success of this process was: (1) de...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74d7594e430e4b5cdc5fe59d563447ea
https://doi.org/10.1021/acs.oprd.0c00052
https://doi.org/10.1021/acs.oprd.0c00052
Publikováno v:
Organic Letters. 18:560-563
An operationally efficient CDI mediated tandem coupling and cyclization reaction to generate [1,2,4]triazolo[4,3-a]pyridines has been reported. The reaction conditions and scope were investigated, and the methodology was demonstrated in batch mode as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b02d521c558726e2ad6940a35a2270
https://doi.org/10.1021/acs.orglett.5b03589
https://doi.org/10.1021/acs.orglett.5b03589
Publikováno v:
Synlett. 26:201-204
A process to access heteroaromatic primary amines from the corresponding heteroaromatic ketones has been developed. A broad range of previously reported methods to convert ketones to primary amines was examined on heterocyclic ketones without success
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ae21e7513ef8b98bbeea8edd863c5cf
https://doi.org/10.1055/s-0034-1379538
https://doi.org/10.1055/s-0034-1379538
Publikováno v:
ChemInform. 47
An operationally efficient CDI mediated tandem coupling and cyclization reaction to generate [1,2,4]triazolo[4,3-a]pyridines has been reported. The reaction conditions and scope were investigated, and the methodology was demonstrated in batch mode as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c23092a86a39d90e9c60dd5e215ebe42
https://doi.org/10.1002/chin.201626183
https://doi.org/10.1002/chin.201626183
Autor:
Jerry A. Murry, Brenda J. Burke, Matthew M. Bio, Margaret M. Faul, Karl B. Hansen, Evan DiVirgilio, Johann Chan, Kyle D. Baucom
Publikováno v:
The Journal of Organic Chemistry. 76:1767-1774
Two new, reliable syntheses of a pyrido[2,3-d]-pyrimidine inhibitor of the CXCR3 receptor are described. A nine-step synthesis of the CXCR3 inhibitor (1) from 2-aminonicotinic acid was demonstrated on a multikilogram scale and incorporates a classic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87e5f31297cd989041fb52b9baa24bc
https://doi.org/10.1021/jo102399a
https://doi.org/10.1021/jo102399a
Publikováno v:
ChemInform. 46
A convenient Raney cobalt-catalyzed hydrogenation of a variety of heterocyclic ketoximes to form primary amines in good selectivity under mild conditions is presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d2be8b965aea48de51f8d17363e209f
https://doi.org/10.1002/chin.201524041
https://doi.org/10.1002/chin.201524041
Publikováno v:
Angewandte Chemie International Edition. 45:1248-1252
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fe5240052e06412abd59dc2735930c
https://doi.org/10.1002/anie.200503991
https://doi.org/10.1002/anie.200503991
Autor:
Johann Chan, Kyle D. Baucom, Christopher J. Borths, Ying Chen, Robert D. Larsen, Jinkun Huang, Margaret M. Faul
Publikováno v:
ChemInform. 41
Heteroarenes are important structural moieties in many chemical industry fields. A highly efficient Pd/Cu-catalyzed C−H arylation method for a range of heterocycles has been discovered. It was found that the key to the success of this transformatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b82237fd94f5a0a99b1db1677c0b1623
https://doi.org/10.1002/chin.201030137
https://doi.org/10.1002/chin.201030137