Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kyle C. Wilcox"'
Autor:
Richard Pracitto, Kyle C. Wilcox, Marcel Lindemann, Jie Tong, Chao Zheng, Songye Li, Sjoerd J. Finnema, Yiyun Huang, Zhengxin Cai
Publikováno v:
ACS Omega, Vol 6, Iss 42, Pp 27676-27683 (2021)
Externí odkaz:
https://doaj.org/article/17f3b403611a4645aecb1b92f553a4b4
Autor:
Marc B. Skaddan, Dustin W. Wooten, Kyle C. Wilcox, Martin J. Voorbach, David R. Reuter, Zhaozhong J. Jia, Kelly D. Foster-Duke, Jonathan A. Hickson, Srirajan Vaidyanathan, Aimee D. Reed, Ann E. Tovcimak, Qi Guo, Robert A. Comley, Lance Lee, Sjoerd J. Finnema, Sarah R. Mudd
Publikováno v:
Molecular Imaging and Biology. 24:830-841
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed24a19138aed93e52318682bc74d325
https://doi.org/10.1007/s11307-022-01733-1
https://doi.org/10.1007/s11307-022-01733-1
Autor:
Paul Tempest, Chin‐Yin Tai, Maiko Ono, Marc B Skaddan, Kyle C Wilcox, Aimee Reed, Srirajan Vaidyanathan, Claus T Christoffersen, Pekka Kallunki, Benny Bang‐Andersen, Richard A Margolin, Tzu‐Huei Kao, Makoto Higuchi, Ming‐Kuei Jang
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dbbb2082a98dc64a4c481983ad9cd7c
https://doi.org/10.1002/alz.063036
https://doi.org/10.1002/alz.063036
Autor:
Ming-Qiang Zheng, Sjoerd J. Finnema, Richard Pracitto, Zhengxin Cai, Jie Tong, Nabeel Nabulsi, Chao Zheng, Zachary Felchner, Krista Fowles, Yiyun Huang, Marcel Lindemann, Li Zhang, Richard E. Carson, Daniel Holden, Kyle C. Wilcox
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 49:1482-1496
Purpose To quantify the synaptic vesicle glycoprotein 2A (SV2A) changes in the whole central nervous system (CNS) under pathophysiological conditions, a high affinity SV2A PET radiotracer with improved in vivo stability is desirable to minimize the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b08fa04c1cd473fe5caef6b7a1359ae
https://doi.org/10.1007/s00259-021-05597-5
https://doi.org/10.1007/s00259-021-05597-5
Autor:
Sjoerd J. Finnema, Chao Zheng, Marcel Lindemann, Songye Li, Kyle C. Wilcox, Zhengxin Cai, Yiyun Huang, Jie Tong, Richard Pracitto
Publikováno v:
ACS Omega, Vol 6, Iss 42, Pp 27676-27683 (2021)
ACS Omega
ACS Omega
A series of synaptic vesicle protein 2A (SV2A) ligands were synthesized to explore the structure-activity relationship and to help further investigate a hydrogen bonding pharmacophore hypothesis. Racemic SynVesT-1 was used as a lead compound to explo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6234df348c3e5c7a0758b9f4d5c83a77
https://doaj.org/article/17f3b403611a4645aecb1b92f553a4b4
https://doaj.org/article/17f3b403611a4645aecb1b92f553a4b4
Autor:
Ivonne Suridjan, Mark Dias, Sjoerd J. Finnema, Nabeel Nabulsi, Yiyun Huang, David Matuskey, Kyle C. Wilcox, Takuya Toyonaga, Richard E. Carson, Jim Ropchan, Brian Pittman, Shannan Henry, Mika Naganawa, Sule Tinaz, Robert A. Comley
Publikováno v:
Annals of Neurology
Objective Parkinson disease is characterized by motor and nonmotor symptoms, reduced striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now known that the pathological process in Parkinson disease may begin decad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de6aaf38d4fec52872144d7772cc873
https://doi.org/10.1002/ana.25682
https://doi.org/10.1002/ana.25682
Autor:
Dustin R. Wakeman, Michael R. Weed, Sylvia E. Perez, Erika N. Cline, Kirsten L. Viola, Kyle C. Wilcox, David S. Moddrelle, Ernell Z. Nisbett, Anish M. Kurian, Amanda F. Bell, Ricaldo Pike, Peer B. Jacobson, William L. Klein, Elliott J. Mufson, Matthew S. Lawrence, John D. Elsworth
Publikováno v:
Neuropathology and applied neurobiologyREFERENCES. 48(4)
An obstacle to developing new treatment strategies for Alzheimer's disease (AD) has been the inadequate translation of findings in current AD transgenic rodent models to the prediction of clinical outcomes. By contrast, nonhuman primates (NHPs) share
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e008c988d7d44fd1dd22787c703de9e0
https://pubmed.ncbi.nlm.nih.gov/35156715
https://pubmed.ncbi.nlm.nih.gov/35156715
Autor:
Chao, Zheng, Daniel, Holden, Ming-Qiang, Zheng, Richard, Pracitto, Kyle C, Wilcox, Marcel, Lindemann, Zachary, Felchner, Li, Zhang, Jie, Tong, Krista, Fowles, Sjoerd J, Finnema, Nabeel, Nabulsi, Richard E, Carson, Yiyun, Huang, Zhengxin, Cai
Publikováno v:
European journal of nuclear medicine and molecular imaging. 49(5)
To quantify the synaptic vesicle glycoprotein 2A (SV2A) changes in the whole central nervous system (CNS) under pathophysiological conditions, a high affinity SV2A PET radiotracer with improved in vivo stability is desirable to minimize the potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::510e9ad70eb36a5c7d7204bb722b9684
https://pubmed.ncbi.nlm.nih.gov/34761284
https://pubmed.ncbi.nlm.nih.gov/34761284
Autor:
Richard E. Carson, Yiyun Huang, Ming-Qiang Zheng, Jie Tong, Daniel Holden, Richard Pracitto, Nabeel Nabulsi, Zhengxin Cai, Li Zhang, Chao Zheng, Marcel Lindemann, Zachary Felchner, Krista Fowles, Kyle C. Wilcox, Sjoerd J. Finnema
PurposeTo investigate the synaptic vesicle glycoprotein 2A (SV2A) expression in the whole central nervous system and peripheral tissues, a metabolically stable SV2A radiotracer is desirable to minimize a potential confounding effect of radiometabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd633f4a16436231b59847e6794ff00c
https://doi.org/10.1101/2021.06.25.449978
https://doi.org/10.1101/2021.06.25.449978
Autor:
Fernanda G. De Felice, Kirsten L. Viola, Nadia DiNunno, Flávia Carvalho Alcantara Gomes, Vanessa Tortelli, William L. Klein, Maira S. Oliveira, Sathwik Nandamuri, Xiao-Wen Yu, Luan Pereira Diniz, Sergio T. Ferreira, Jason Pitt, Kyle C. Wilcox, Cassandra Dobbins
Publikováno v:
Molecular Biology of the Cell
Findings reveal a novel basis for protecting CNS neurons against Aβ oligomers (AβOs), neurotoxins believed to instigate neural damage leading to Alzheimer’s dementia. Results with spatially separated cocultures of astrocytes and hippocampal neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e7115b6ec62e913efd93442d0a5682
https://pubmed.ncbi.nlm.nih.gov/28963439
https://pubmed.ncbi.nlm.nih.gov/28963439