Výsledky vyhledávání - "Kyle C Kurek"

Akademický článek

Anti-lubricin monoclonal antibodies created using lubricin-knockout mice immunodetect lubricin in several species and in patients with healthy and diseased joints.

Autor: Minrong Ai, Yajun Cui, Man-Sun Sy, David M Lee, Ling Xiu Zhang, Katherine M Larson, Kyle C Kurek, Gregory D Jay, Matthew L Warman

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0116237 (2015)

Lubricin, encoded by the gene PRG4, is the principal lubricant in articulating joints. We immunized mice genetically deficient for lubricin (Prg4-/-) with purified human lubricin, and generated several mAbs. We determined each mAb's binding epitope,

Externí odkaz: https://doaj.org/article/7fea246c7dc54b05b0c19147fec8487b

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Akademický článek

SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates.

Autor: Margot E Bowen, Ugur M Ayturk, Kyle C Kurek, Wentian Yang, Matthew L Warman

Publikováno v: PLoS Genetics, Vol 10, Iss 5, p e1004364 (2014)

Loss of PTPN11/SHP2 in mice or in human metachondromatosis (MC) patients causes benign cartilage tumors on the bone surface (exostoses) and within bones (enchondromas). To elucidate the mechanisms underlying cartilage tumor formation, we investigated

Externí odkaz: https://doaj.org/article/161d62f3c19a435bb3f2b0e5cc792c22

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Akademický článek

Loss-of-function mutations in PTPN11 cause metachondromatosis, but not Ollier disease or Maffucci syndrome.

Publikováno v: PLoS Genetics, Vol 7, Iss 4, p e1002050 (2011)

Metachondromatosis (MC) is a rare, autosomal dominant, incompletely penetrant combined exostosis and enchondromatosis tumor syndrome. MC is clinically distinct from other multiple exostosis or multiple enchondromatosis syndromes and is unlinked to EX

Externí odkaz: https://doaj.org/article/5bdd2086ded74319acfef993578bc155

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Supplementary Methods, Figure Legends, Figures S1 - S6, Tables S1, S3 - S6, S8 - S15, S17 from The Genomic Landscape of Pediatric Ewing Sarcoma

This file contains supplementary methods, supplementary references, supplementary figures S1-S6, supplementary tables S1, S3-S6, S8-S15, and S17, and legends for all supplementary figures and tables. Supplementary Figure S1. Summary of Ewing sarcoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9fa9a2acd9aa5b17ee580f829aa8bd
https://doi.org/10.1158/2159-8290.22530080

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Supplementary Table S7 from The Genomic Landscape of Pediatric Ewing Sarcoma

Variants identified from WES of 92 tumors after filtering.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7b338c898e7488e092dfc96651fc5b
https://doi.org/10.1158/2159-8290.22530068

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Data from The Genomic Landscape of Pediatric Ewing Sarcoma

Pediatric Ewing sarcoma is characterized by the expression of chimeric fusions of EWS and ETS family transcription factors, representing a paradigm for studying cancers driven by transcription factor rearrangements. In this study, we describe the som

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285f277c0a412b54bb52bd7d1d0693b6
https://doi.org/10.1158/2159-8290.c.6546101

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Supplementary Tables 1-10, Figures 1-6, Methods from Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma Is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression

Autor: Rami I. Aqeilan, Jane B. Lian, Janet L. Stein, Gary S. Stein, Matthew Warman, Mark Gebhardt, Gail Amir, Barry DeYoung, Kevin B. Jones, Nicola Zanesi, Eugenio Gaudio, Suk-hee Lee, Hussain Sadiq, Suhaib Abdeen, Zaidoun Salah, Sara Del Mare, Kyle C. Kurek

Supplementary Tables 1-10, Figures 1-6, Methods from Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma Is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492d7e2e163e9d5c3ed3728da8a5e0c7
https://doi.org/10.1158/0008-5472.22383887.v1

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Data from Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma Is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression

The WW domain-containing oxidoreductase (WWOX) is a tumor suppressor that is deleted or attenuated in most human tumors. Wwox-deficient mice develop osteosarcoma (OS), an aggressive bone tumor with poor prognosis that often metastasizes to lung. On t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcc5c56e22644e64bf164b07ff04dc43
https://doi.org/10.1158/0008-5472.c.6500696

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Kaposiform Lymphangiomatosis

Publikováno v: American Journal of Surgical Pathology. 46:963-976

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::572947fccc4a713a80a2218c5cf5bab1
https://doi.org/10.1097/pas.0000000000001898

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CAP-ACP Workload Model for Advanced Diagnostics in Precision Medicine

Autor: Paul C Park, Kyle C Kurek, John DeCoteau, Christopher J Howlett, Cynthia Hawkins, Iyare Izevbaye, Michael D Carter, Margaret Redpath, Bryan Lo, Deepu Alex, George Yousef, Stephen Yip, Raymond Maung

Publikováno v: American Journal of Clinical Pathology. 158:105-111

Objectives In precision medicine, where oncologic management is tailored to the individual’s clinical and genetic profiles, advanced diagnostic testing provides prognostic information and guides management in a growing number of malignancies. There

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b77b4702f0a935dc00818eda7d081b
https://doi.org/10.1093/ajcp/aqac012

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