Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kyle Bromma"'
Publikováno v:
Cancer Nanotechnology, Vol 14, Iss 1, Pp 1-26 (2023)
Abstract Background Much in vitro research on the applicability of gold nanoparticles (GNPs) in cancer treatment has been focused on two-dimensional (2D) monolayer models. To improve this, we explored the effect of the combination of GNPs and docetax
Externí odkaz:
https://doaj.org/article/36c7455df08742308a2e06625ffab284
Autor:
Nolan Jackson, Iona Hill, Abdulaziz Alhussan, Kyle Bromma, Jessica Morgan, Belal Abousaida, Yasmin Zahra, Yuri Mackeyev, Wayne Beckham, Steven Herchko, Sunil Krishnan, Devika Basnagge Chithrani
Publikováno v:
Cancer Nanotechnology, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Background Radiotherapy (RT) is an essential component in the treatment regimens for many cancer patients. However, the dose escalation required to improve curative results is hindered due to the normal tissue toxicity that is induced. The i
Externí odkaz:
https://doaj.org/article/6ce8b63f7600436ba73912bcded292c8
Autor:
Kyle Bromma, Nancy Dos Santos, Ingrid Barta, Abraham Alexander, Wayne Beckham, Sunil Krishnan, Devika B. Chithrani
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Recent clinical trials show docetaxel (DTX), given in conjunction with radiation therapy (RT) and androgen suppression, improves survival in high-risk prostate cancer. Addition of gold nanoparticles (GNPs) to this current DTX/RT protocol is
Externí odkaz:
https://doaj.org/article/e49fc97f980f416e966cd2ae708ed4c6
Autor:
Abdulaziz Alhussan, Kyle Bromma, Ece Pinar Demirci Bozdoğan, Andrew Metcalfe, Joanna Karasinska, Wayne Beckham, Abraham S. Alexander, Daniel J. Renouf, David F. Schaeffer, Devika B. Chithrani
Publikováno v:
Current Oncology, Vol 28, Iss 3, Pp 1962-1979 (2021)
Pancreatic cancer is one of the deadliest types of cancer, with a five-year survival rate of only 10%. Nanotechnology offers a novel perspective to treat such deadly cancers through their incorporation into radiotherapy and chemotherapy. However, the
Externí odkaz:
https://doaj.org/article/83da062e6af1442aabd6135833a9a5a2
Publikováno v:
Cancer Nanotechnology, Vol 11, Iss 1, Pp 1-16 (2020)
Abstract Successful integration of nanotechnology into the current paradigm of cancer therapy requires proper understanding of the interface between nanoparticles (NPs) and cancer cells, as well as other key components within the tumor microenvironme
Externí odkaz:
https://doaj.org/article/e7417468d24443228b5e383d723f8c58
Autor:
Nolan Jackson, Abdulaziz Alhussan, Kyle Bromma, David Jay, James C. Donnelly, Frederick G. West, Afsaneh Lavasanifar, Michael Weinfeld, Wayne Beckham, Devika B. Chithrani
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2795 (2022)
Radiation therapy (RT) is frequently used to locally treat tumors. One of the major issues in RT is normal tissue toxicity; thus, it is necessary to limit dose escalation for enhanced local control in patients that have locally advanced tumors. Integ
Externí odkaz:
https://doaj.org/article/a9ada600b46941b1bddf75ccea8a198c
Autor:
Kyle Bromma, Kristy Rieck, Jayesh Kulkarni, Connor O’Sullivan, Wonmo Sung, Pieter Cullis, Jan Schuemann, Devika B. Chithrani
Publikováno v:
Cancer Nanotechnology, Vol 10, Iss 1, Pp 1-17 (2019)
Abstract Background Radiotherapy is commonly used for treating cancer. Novel sensitizers, such as gold nanoparticles (GNPs), are being used to enhance the local radiation dose. It is not known how the uptake and radiation dose enhancement of GNPs var
Externí odkaz:
https://doaj.org/article/38df13f482774eaf907c54067bc376fe
Autor:
Ocean Han, Kyle Bromma, Nicholas Palmerley, Ariadne T. Bido, Mesa Monica, Abdulaziz Alhussan, Perry L. Howard, Alexandre G. Brolo, Wayne Beckham, Abraham S. Alexander, Devika B. Chithrani
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 233 (2022)
One of the major issues in current radiotherapy (RT) is the associated normal tissue toxicity. Enhancement of the RT effect with novel radiosensitizers can address this need. In this study, gold nanoparticles (GNPs) and bleomycin (BLM) were used as a
Externí odkaz:
https://doaj.org/article/87f5da8383a9467a93968a3517d79793
Autor:
Celina Yang, Kyle Bromma, Caterina Di Ciano-Oliveira, Gaetano Zafarana, Monique van Prooijen, Devika B. Chithrani
Publikováno v:
Cancer Nanotechnology, Vol 9, Iss 1, Pp 1-14 (2018)
Abstract Background The combined use of radiation therapy and chemotherapy is commonly being used in cancer treatment. The side effects of the treatment can be further minimized through targeted delivery of anticancer drugs and local enhancement of t
Externí odkaz:
https://doaj.org/article/0631bb869e1846829f92ee58393d7ed1
Autor:
Kyle Bromma, Devika B. Chithrani
Publikováno v:
Nanomaterials, Vol 10, Iss 9, p 1671 (2020)
According to the global cancer observatory (GLOBOCAN), there are approximately 18 million new cancer cases per year worldwide. Cancer therapies are largely limited to surgery, radiotherapy, and chemotherapy. In radiotherapy and chemotherapy, the maxi
Externí odkaz:
https://doaj.org/article/a3198a7921c44e8fa36533056eb4327b