Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kyle B. Vrtis"'
Autor:
Yanxia Bei, Kaylinnette Pinet, Kyle B. Vrtis, Janine G. Borgaro, Luo Sun, Matthew Campbell, Lynne Apone, Bradley W. Langhorst, Nicole M. Nichols
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Prompt and accurate pathogen identification, by diagnostics and sequencing, is an effective tool for tracking and potentially curbing pathogen spread. Targeted detection and amplification of viral genomes depends on annealing complementary oligonucle
Externí odkaz:
https://doaj.org/article/f200ed015f1849b29c091c244276a706
The emergence of new SARS-CoV-2 variants necessitates the reevaluation of current COVID-19 tests to ensure continued accuracy and reliability. The new SARS-CoV-2 variant, Omicron, is heavily mutated, with over 50 mutations within its RNA genome. Any
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91c32d00cc3b6552855aad4711b6a4ff
https://doi.org/10.1101/2021.12.16.21267734
https://doi.org/10.1101/2021.12.16.21267734
Autor:
Johannes C. Walter, Thomas G.W. Graham, Kyle B. Vrtis, Gheorghe Chistol, James M. Dewar, R. Alex Wu
SummaryDNA damage impedes replication fork progression and threatens genome stability. Upon encounter with most DNA adducts, the replicative CMG helicase (CDC45-MCM2-7-GINS) stalls or uncouples from the point of synthesis, yet CMG eventually resumes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9bd261bc101dde8b7ee171a85eef4ff
https://doi.org/10.1101/2020.08.17.254235
https://doi.org/10.1101/2020.08.17.254235
Autor:
Thomas G.W. Graham, Johannes C. Walter, R. Alex Wu, Gheorghe Chistol, James M. Dewar, Kyle B. Vrtis
Publikováno v:
Mol Cell
DNA damage impedes replication fork progression and threatens genome stability. Upon encounter with most DNA adducts, the replicative CMG helicase (CDC45-MCM2-7-GINS) stalls or uncouples from the point of synthesis, yet eventually resumes replication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d8c0f8f5f5bc0760c60a4aa0aeb7c9
https://doi.org/10.1016/j.molcel.2020.12.039
https://doi.org/10.1016/j.molcel.2020.12.039
Publikováno v:
Nucleic Acids Research
The mechanism by which DNA polymerases achieve their extraordinary accuracy has been intensely studied because of the linkage between this process and mutagenesis and carcinogenesis. Here, we have used single-molecule fluorescence microscopy to study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f5a76339c25ca6cb3066712a10e9e0
https://pubmed.ncbi.nlm.nih.gov/22669904
https://pubmed.ncbi.nlm.nih.gov/22669904
Autor:
Pavani, Raphael, Tripathi, Veenu, Vrtis, Kyle B., Dali Zong, Chari, Raj, Callen, Elsa, Pankajam, Ajith V., Gang Zhen, Matos-Rodrigues, Gabriel, Jiajie Yang, Shuheng Wu, Reginato, Giordano, Wei Wu, Cejka, Petr, Walter, Johannes C., Nussenzweig, André andre_nussenzweig@nih.gov
Publikováno v:
Science. 8/16/2024, Vol. 385 Issue 6710, p728-728. 1p. 1 Diagram.
Publikováno v:
Genomics & Genetics Weekly; 7/12/2024, p874-874, 1p
Publikováno v:
Biophysical Journal. (2):176a
DNA polymerases must accurately replicate DNA to maintain the integrity of the genome. Carcinogenic adducts, such as 2-aminofluorene (AF) and N-acetyl-2-aminofluorene (AAF), are covalently bound to bases on DNA leading to altered DNA polymerase activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3e24a08f0673c31d02a53b2d0e782f
Publikováno v:
Nucleic Acids Research; Sep2013, Vol. 41 Issue 16, p7843-7853, 11p
Publikováno v:
Nucleic Acids Research; Sep2012, Vol. 40 Issue 16, p7975-7984, 10p