Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kyle B. Lupo"'
Autor:
Kyle B. Lupo, Xue Yao, Shambhavi Borde, Jiao Wang, Sandra Torregrosa-Allen, Bennett D. Elzey, Sagar Utturkar, Nadia A. Lanman, MacKenzie McIntosh, Sandro Matosevic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Severe heterogeneity within glioblastoma has spurred the notion that disrupting the interplay between multiple elements on immunosuppression is at the core of meaningful anti-tumor responses. T cell immunoreceptor with Ig and ITIM domains (T
Externí odkaz:
https://doaj.org/article/1e2e1119049944b2a09484ad5864089e
TIGIT contributes to the regulation of 4-1BB and does not define NK cell dysfunction in glioblastoma
Autor:
Kyle B. Lupo, Sandra Torregrosa-Allen, Bennett D. Elzey, Sagar Utturkar, Nadia A. Lanman, Aaron A. Cohen-Gadol, Veronika Slivova, MacKenzie McIntosh, Karen E. Pollok, Sandro Matosevic
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108353- (2023)
Summary: TIGIT is a receptor on human natural killer (NK) cells. Here, we report that TIGIT does not spontaneously induce inhibition of NK cells in glioblastoma (GBM), but rather acts as a decoy-like receptor, by usurping binding partners and regulat
Externí odkaz:
https://doaj.org/article/fc412162de6f40f686eec4555f885cb5
Autor:
Kyle B. Lupo, Sandro Matosevic
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-10 (2020)
Abstract Natural killer (NK) cells are powerful immune effectors, modulating their anti-tumor function through a balance activating and inhibitor ligands on their cell surface. Though still emerging, cancer immunotherapies utilizing NK cells are prov
Externí odkaz:
https://doaj.org/article/b633a8e291024570882c0cf394c7fcd3
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Background The anti-tumor immunity of natural killer (NK) cells can be paralyzed by the CD73-induced generation of immunosuppressive adenosine from precursor ATP within the hypoxic microenvironment of solid tumors. In an effort to redirect p
Externí odkaz:
https://doaj.org/article/310ee4e3f6304b9b8529a713767b46a5
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Energy metabolism is key to the promotion of tumor growth, development, and metastasis. At the same time, cellular metabolism also mediates immune cell survival, proliferation and cytotoxic responses within the tumor microenvironment. The ability of
Externí odkaz:
https://doaj.org/article/f078505dfdb0495285c983ceab5b7282
Autor:
Andrea M. Chambers, Jiao Wang, Kyle B. Lupo, Hao Yu, Nadia M. Atallah Lanman, Sandro Matosevic
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Adenosine is a potent immunosuppressive purine metabolite contributing to the pathogenesis of solid tumors. Extracellular adenosine signals on tumor-infiltrating NK cells to inhibit their proliferation, maturation, and cytotoxic function. Cytokine pr
Externí odkaz:
https://doaj.org/article/3888a1e798b34ecfa2561027770222fe
Autor:
Andrea M Chambers, Kyle B Lupo, Jiao Wang, Jingming Cao, Sagar Utturkar, Nadia Lanman, Victor Bernal-Crespo, Shadia Jalal, Sharon R Pine, Sandra Torregrosa-Allen, Bennett D Elzey, Sandro Matosevic
Publikováno v:
eLife, Vol 11 (2022)
Immunometabolic reprogramming due to adenosine produced by CD73 (encoded by the 5’-ectonucleotidase gene NT5E) is a recognized immunosuppressive mechanism contributing to immune evasion in solid tumors. Adenosine is not only known to contribute to
Externí odkaz:
https://doaj.org/article/97d6c81764a042458eef5e324c28f106
Autor:
Andrea M. Chambers, Jiao Wang, Tram N. Dao, Kyle B. Lupo, Paige Veenhuis, Mitchell G. Ayers, Veronika Slivova, Aaron A. Cohen-Gadol, Sandro Matosevic
Publikováno v:
Cancer Immunology, Immunotherapy. 71:3043-3056
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8b7625066f6459f515aeb78a2507af3
https://doi.org/10.1007/s00262-022-03219-z
https://doi.org/10.1007/s00262-022-03219-z
Autor:
S. Toregrosa-Allen, N. Atallah Lanman, Shadia I. Jalal, Andrea M. Chambers, Jian Wang, Sandro Matosevic, Bennett D. Elzey, Victor Bernal-Crespo, S. Pine, Sagar M. Utturkar, Kyle B. Lupo, Jiayue Cao
Publikováno v:
eLife. 11
Immunometabolic reprogramming due to adenosine produced by CD73 (encoded by the 5'-ectonucleotidase gene NT5E) is a recognized immunosuppressive mechanism contributing to immune evasion in solid tumors. Adenosine is not only known to contribute to tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019829c4a77cb38074b2599479fb31c0
https://doi.org/10.7554/elife.73699
https://doi.org/10.7554/elife.73699
Autor:
Andrea M Chambers, Kyle B Lupo, Jiao Wang, Jingming Cao, Sagar Utturkar, Nadia Lanman, Victor Bernal-Crespo, Shadia Jalal, Sharon R Pine, Sandra Torregrosa-Allen, Bennett D Elzey, Sandro Matosevic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d5a8372eda94200577042a76c33f18b
https://doi.org/10.7554/elife.73699.sa2
https://doi.org/10.7554/elife.73699.sa2
