Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kyle B. LaPenna"'
Autor:
Jake E. Doiron, Zhen Li, Xiaoman Yu, Kyle B. LaPenna, Heather Quiriarte, Timothy D. Allerton, Kashyap Koul, Andrew Malek, Sanjiv J. Shah, Thomas E. Sharp, Traci T. Goodchild, Daniel R. Kapusta, David J. Lefer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 4 (2024)
Background The renal sympathetic nervous system modulates systemic blood pressure, cardiac performance, and renal function. Pathological increases in renal sympathetic nerve activity contribute to the pathogenesis of heart failure with preserved ejec
Externí odkaz:
https://doaj.org/article/377b6dd424934dd9a1525c1d2e497cee
Autor:
Kyle B. LaPenna, Zhen Li, Jake E. Doiron, Thomas E. Sharp, Huijing Xia, Karl Moles, Kashyap Koul, John S. Wang, David J. Polhemus, Traci T. Goodchild, Ravi B. Patel, Sanjiv J. Shah, David J. Lefer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 4 (2023)
Background Recent studies have suggested that cardiac nitrosative stress mediated by pathological overproduction of nitric oxide (NO) via inducible NO synthase (iNOS) contributes to the pathogenesis of heart failure with preserved ejection fraction (
Externí odkaz:
https://doaj.org/article/7aac073711094e04ba91e3ff73aa8fb6
Autor:
Jake Doiron, Zhen Li, Huijing Xia, Kyle B. Lapenna, Timothy D. Allerton, Daniel R. Kapusta, David J. Lefer
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 108-108 (2023)
OBJECTIVES/GOALS: SGLT2i therapy is currently a cornerstone in heart failure with preserved ejection fraction (HFpEF) therapy. Similarly, H2S has been shown to be beneficial in preclinical models of heart failure. With this in mind, we sought to inve
Externí odkaz:
https://doaj.org/article/7c8d629aa0cc47b5be07f44d739a356d
Autor:
Kyle B. LaPenna, David J. Polhemus, Jake E. Doiron, Hunter A. Hidalgo, Zhen Li, David J. Lefer
Publikováno v:
Antioxidants, Vol 10, Iss 3, p 485 (2021)
Hydrogen sulfide (H2S) is an endogenous, gaseous signaling molecule that plays a critical role in cardiac and vascular biology. H2S regulates vascular tone and oxidant defenses and exerts cytoprotective effects in the heart and circulation. Recent st
Externí odkaz:
https://doaj.org/article/d04350a08e2e4f3690b8fb9332a7acc7
Autor:
Feng Gao, Brandon P. Lucke-Wold, Xiang Li, Aric F. Logsdon, Li-Chong Xu, Sulei Xu, Kyle B. LaPenna, Huaqi Wang, M. A. Hassan Talukder, Christopher A. Siedlecki, Jason D. Huber, Charles L. Rosen, Pingnian He
Publikováno v:
Frontiers in Physiology, Vol 8 (2018)
Nitric oxide (NO) is a known anti-adhesive molecule that prevents platelet aggregation and leukocyte adhesion to endothelial cells (ECs). The mechanism has been attributed to its role in the regulation of adhesion molecules on leukocytes and the adhe
Externí odkaz:
https://doaj.org/article/d35b1ac8ed2c45688e4023d390b951ca
Autor:
Zhen Li, Huijing Xia, Thomas E. Sharp, Kyle B. LaPenna, Antonia Katsouda, John W. Elrod, Josef Pfeilschifter, Karl-Friedrich Beck, Shi Xu, Ming Xian, Traci T. Goodchild, Andreas Papapetropoulos, David J. Lefer
Publikováno v:
Circulation Research. 132:154-166
Background: Hydrogen sulfide is a critical endogenous signaling molecule that exerts protective effects in the setting of heart failure. Cystathionine γ-lyase (CSE), 1 of 3 hydrogen-sulfide–producing enzyme, is predominantly localized in the vascu
Autor:
Zhen, Li, Huijing, Xia, Thomas E, Sharp, Kyle B, LaPenna, John W, Elrod, Kevin M, Casin, Ken, Liu, John W, Calvert, Vinh Q, Chau, Fadi N, Salloum, Shi, Xu, Ming, Xian, Noriyuki, Nagahara, Traci T, Goodchild, David J, Lefer
Publikováno v:
Circulation research. 131(3)
Hydrogen sulfide (HHuman myocardial samples obtained from patients with heart failure undergoing cardiac surgeries were probed for 3-MST protein expression. 3-MST knockout mice and C57BL/6J wild-type mice were subjected to transverse aortic constrict
Autor:
Zhen Li, Huijing Xia, Thomas E. Sharp, Kyle B. LaPenna, John W. Elrod, Kevin M. Casin, Ken Liu, John W. Calvert, Vinh Q. Chau, Fadi N. Salloum, Shi Xu, Ming Xian, Noriyuki Nagahara, Traci T. Goodchild, David J. Lefer
Publikováno v:
Circulation Research. 131:222-235
Background: Hydrogen sulfide (H 2 S) exerts mitochondria-specific actions that include the preservation of oxidative phosphorylation, biogenesis, and ATP synthesis, while inhibiting cell death. 3-MST (3-mercaptopyruvate sulfurtransferase) is a mitoch
Autor:
Anna K. Whitehead, Nicholas D. Fried, Zhen Li, Kandasamy Neelamegam, Charlotte S. Pearson, Kyle B. LaPenna, Thomas E. Sharp, David J. Lefer, Eric Lazartigues, Jason D. Gardner, Xinping Yue
Publikováno v:
Clin Sci (Lond)
Cigarette smoking remains the leading modifiable risk factor for cardiopulmonary diseases; however, the effects of nicotine alone on cardiopulmonary function remain largely unknown. Previously, we have shown that chronic nicotine vapor inhalation in
Publikováno v:
Obesity Surgery. 31:4911-4917
Circulating micronutrient levels of both serum copper and zinc have been studied to varying degrees in both the general public and patients having undergone bariatric surgery. According to the 2019 ASMBS clinical guidelines, copper supplementation is