Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kyle B Fraser"'
Autor:
Hisham Abdelmotilib, Tyler Maltbie, Vedad Delic, Zhiyong Liu, Xianzhen Hu, Kyle B. Fraser, Mark S. Moehle, Lindsay Stoyka, Nadia Anabtawi, Valentina Krendelchtchikova, Laura A. Volpicelli-Daley, Andrew West
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105506- (2021)
Externí odkaz:
https://doaj.org/article/93d0990612304cb6b991a966e258431a
Autor:
Hisham Abdelmotilib, Tyler Maltbie, Vedad Delic, Zhiyong Liu, Xianzhen Hu, Kyle B. Fraser, Mark S. Moehle, Lindsay Stoyka, Nadia Anabtawi, Valentina Krendelchtchikova, Laura A. Volpicelli-Daley, Andrew West
Publikováno v:
Neurobiology of Disease, Vol 105, Iss , Pp 84-98 (2017)
Proteinaceous inclusions in neurons, composed primarily of α-synuclein, define the pathology in several neurodegenerative disorders. Neurons can internalize α-synuclein fibrils that can seed new inclusions from endogenously expressed α-synuclein.
Externí odkaz:
https://doaj.org/article/347b02afbcd14d3d81e45e37ff8d7b1b
Autor:
D. A. Cook, G. T. Kannarkat, A. F. Cintron, Laura M. Butkovich, Kyle B. Fraser, J. Chang, N. Grigoryan, S. A. Factor, Andrew B. West, J. M. Boss, M. G. Tansey
Publikováno v:
npj Parkinson's Disease, Vol 3, Iss 1, Pp 1-12 (2017)
Immune system regulation: A known suspect High levels of leucine-rich repeat kinase 2 (LRRK2) in immune cells disrupt immune system function in patients with Parkinson’s disease (PD). Mutations in LRRK2 are the most common genetic cause of PD. Alth
Externí odkaz:
https://doaj.org/article/6c926ddf8a1d4b89b93c4407e58bb695
Autor:
Nurit Omer, Tanya Gurevich, Nir Giladi, Julia C Shirvan, Avner Thaler, Jesse M. Cedarbaum, Orly Goldstein, Mali Gana-Weisz, Meir Kestenbaum, Avi Orr-Urtreger, Kyle B Fraser, Anat Bar-Shira, Tal Glinka, Anat Mirelman, Omar S Mabrouk
Publikováno v:
Movement Disorders. 37:651-652
Background Mutations in the GBA gene, which encodes the lysosomal enzyme glucocerebrosidase (GCase), are risk factors for Parkinson's disease (PD). Objective To explore the association between GCase activity, PD phenotype, and probability for prodrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f2104ad5b0a986e2043d7eff032c72
https://doi.org/10.1002/mds.28929
https://doi.org/10.1002/mds.28929
Autor:
Ahmed T. Kurdi, Ralph Weissleder, Leonardo V. Riella, Jamil Azzi, Sangmoo Jeong, Hsing Ying Lin, Siawosh K. Eskandari, Sujit Routray, Anil Chandraker, Kyungheon Lee, Kyle B. Fraser, Bakhos A. Tannous, Jean Pierre Assaker, Chen Han Huang, Changwook Min, Hakho Lee, Jongmin Park, Cesar M. Castro, Reza Abdi
Publikováno v:
ACS Nano. 11:11041-11046
Kidney transplant patients require life-long surveillance to detect allograft rejection. Repeated biopsy, albeit the clinical gold standard, is an invasive procedure with the risk of complications and comparatively high cost. Conversely, serum creati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf395aaa122b916c87a4e5eb373dd67
https://doi.org/10.1021/acsnano.7b05083
https://doi.org/10.1021/acsnano.7b05083
Autor:
Andrew B. West, Kyle B. Fraser, Nianjun Liu, Roy N. Alcalay, Rachel G. Clark, David G. Standaert, Ashlee B. Rawlins
Publikováno v:
Movement Disorders. 31:1543-1550
Background Mutations in Leucine-rich repeat kinase 2 (LRRK2) enhance levels of the autophosphorylated LRRK2 protein and are the most common known cause of inherited Parkinson's disease (PD). LRRK2 has been further implicated in susceptibility to idio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f283cef6c5cbcf52f68cf4349a8422d2
https://doi.org/10.1002/mds.26686
https://doi.org/10.1002/mds.26686
Autor:
Tomasz Szul, Michele Kong, Kyle B. Fraser, Sunil Rangarajan, J. Edwin Blalock, Rabindra Tirouvanziam, Preston E. Bratcher, Elizabeth Sztul, Xin Xu, Sarah A. Ingersoll, Amit Gaggar
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 54:359-369
Proteases are important regulators of pulmonary remodeling and airway inflammation. Recently, we have characterized the enzyme prolyl endopeptidase (PE), a serine peptidase, as a critical protease in the generation of the neutrophil chemoattractant t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9f16cb336fe19e1fa3fd52a650e486
https://doi.org/10.1165/rcmb.2015-0108oc
https://doi.org/10.1165/rcmb.2015-0108oc
Autor:
Hakho Lee, Xandra O. Breakefield, Ralph Weissleder, Leonora Balaj, Kyungheon Lee, Kyle B. Fraser, Bassel Ghaddar, Eunha Kim, E. Antonio Chiocca, Katy Yang
Extracellular vesicles (EV) are a family of cell-originating, membrane-enveloped nanoparticles with diverse biological function, diagnostic potential, and therapeutic applications. While EV can be abundant in circulation, their small size (∼4 order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9caefd1ae306b01ad099cd3f00396038
https://europepmc.org/articles/PMC5898240/
https://europepmc.org/articles/PMC5898240/
Autor:
João Paulo Lima Daher, Andrew B. West, Warren D. Hirst, Stefanus J. Steyn, Mark S. Moehle, Hisham Abdelmotilib, Laura A. Volpicelli-Daley, Elie Needle, Xianzhen Hu, Paul Galatsis, Yi Chen, Kyle B. Fraser
Publikováno v:
Journal of Biological Chemistry. 290:19433-19444
Therapeutic approaches to slow or block the progression of Parkinson disease (PD) do not exist. Genetic and biochemical studies implicate α-synuclein and leucine-rich repeat kinase 2 (LRRK2) in late-onset PD. LRRK2 kinase activity has been linked to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33003aa29a17b64485ee9ab6c36fa2bd
https://doi.org/10.1074/jbc.m115.660001
https://doi.org/10.1074/jbc.m115.660001
Autor:
Tyler Maltbie, Kyle B. Fraser, Hisham Abdelmotilib, Laura A. Volpicelli-Daley, Xianzhen Hu, Zhiyong Liu, Vedad Delic, Nadia M. Anabtawi, Valentina Krendelchtchikova, Mark S. Moehle, Andrew B. West, Lindsay E. Stoyka
Publikováno v:
Neurobiology of Disease, Vol 105, Iss, Pp 84-98 (2017)
Proteinaceous inclusions in neurons, composed primarily of α-synuclein, define the pathology in several neurodegenerative disorders. Neurons can internalize α-synuclein fibrils that can seed new inclusions from endogenously expressed α-synuclein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f05fe944f27018b2e2cd74f72cb44a
https://europepmc.org/articles/PMC5701756/
https://europepmc.org/articles/PMC5701756/