Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kyle A. Wegner"'
Autor:
Bernadette M. M. Zwaans, Kyle A. Wegner, Sarah N. Bartolone, Chad M. Vezina, Michael B. Chancellor, Laura E. Lamb
Publikováno v:
Physiological Reports, Vol 8, Iss 4, Pp n/a-n/a (2020)
Abstract A subset of patients receiving radiation therapy for pelvic cancer develop radiation cystitis, a complication characterized by mucosal cell death, inflammation, hematuria, and bladder fibrosis. Radiation cystitis can reduce bladder capacity,
Externí odkaz:
https://doaj.org/article/5234d0f3be2749f0896a816ca62ea171
Autor:
Kyle A. Wegner, Vatsal Mehta, Jeanette A. Johansson, Brett R. Mueller, Kimberly P. Keil, Lisa L. Abler, Paul C. Marker, M. Mark Taketo, Denis J. Headon, Chad M. Vezina
Publikováno v:
Biology Open, Vol 8, Iss 3 (2019)
Beta-catenin (CTNNB1) directs ectodermal appendage spacing by activating ectodysplasin A receptor (EDAR) transcription, but whether CTNNB1 acts by a similar mechanism in the prostate, an endoderm-derived tissue, is unclear. Here we examined the expre
Externí odkaz:
https://doaj.org/article/469cf7752b1946f9b7faee988ecbd3f1
Autor:
Chelsea A. O’Driscoll, Hannah Ruetten, Britta Chelgren, Chad M. Vezina, Mark Cadena, Lisa L. Abler, Jonathan Zhu, Dale E. Bjorling, Kyle A Wegner, Zunyi Wang, Jaskiran K Sandhu, Peiqing Wang, Helen L Zhang, Simran K. Sandhu, Jonathan Barasch, Tian Shen, Brett Mueller
Publikováno v:
American Journal of Physiology-Renal Physiology. 320:F31-F46
Bacterial infection is one known etiology of prostatic inflammation. Prostatic inflammation is associated with prostatic collagen accumulation and both are linked to progressive lower urinary tract symptoms in men. We characterized a model of prostat
Impact of sex, androgens, and prostate size on C57BL/6J mouse urinary physiology: urethral histology
Autor:
Hannah Ruetten, Jacquelyn Morkrid, Anne E. Turco, Helen L Zhang, William A. Ricke, Kyle A Wegner, Paul C. Marker, Simran K. Sandhu, Richard E. Peterson, Conner L. Kennedy, Peiqing Wang, Dale E. Bjorling, Chad M. Vezina, Jill A. Macoska, Zunyi Wang, Jaskiran K Sandhu
Publikováno v:
Am J Physiol Renal Physiol
The National Institutes of Health leveled new focus on sex as a biological variable with the goal of understanding sex-specific differences in health and physiology. We previously published a functional assessment of the impact of sex, androgens, and
Autor:
Chad M. Vezina, Richard B. Halberg, Steven R Oakes, Brett Mueller, Paul C. Marker, Hannah Ruetten, Christopher J Unterberger, Anne E. Turco, Nicholas M Girardi, Steven M. Swanson, Enrique J Avila, Kyle A Wegner
Publikováno v:
J Pathol
We genetically engineered expression of an activated form of P110 alpha, the catalytic subunit of PI3K, in mouse prostate epithelium to create a mouse model of direct PI3K activation (Pbsn-cre4Prb;PI3KGOF/+ ). We hypothesized that direct activation w
Autor:
Kyle A Wegner, Richard E. Peterson, Helen L Zhang, Paul C. Marker, Jill A. Macoska, Simran K. Sandhu, Zunyi Wang, Chad M. Vezina, Dale E. Bjorling, Hannah Ruetten, William A. Ricke, Jaskiran K Sandhu, Peiqing Wang, Brett Mueller, Jacquelyn Morkrid
Publikováno v:
Toxicol Pathol
The purpose of this symposium report is to summarize information from a session 3 oral presentation at the Society of Toxicologic Pathology Annual Symposium in Raleigh, North Carolina. Mice are genetically tractable and are likely to play an importan
Autor:
Kyle A Wegner, Paul C. Marker, Simran K. Sandhu, Brett Mueller, Helen L Zhang, William A. Ricke, Richard E. Peterson, Hannah Ruetten, Jill A. Macoska, Peiqing Wang, Jaskiran K Sandhu, Zunyi Wang, Dale E. Bjorling, Chad M. Vezina
Publikováno v:
Am J Physiol Renal Physiol
Laboratory mice are used to identify causes of urinary dysfunction including prostate-related mechanisms of lower urinary tract symptoms. Effective use of mice for this purpose requires a clear understanding of molecular, cellular, anatomic, and endo
Autor:
Kyle A, Wegner, Hannah, Ruetten, Nicholas M, Girardi, Chelsea A, O'Driscoll, Jaskiran K, Sandhu, Anne E, Turco, Lisa L, Abler, Peiqing, Wang, Zunyi, Wang, Dale E, Bjorling, Rita, Malinowski, Richard E, Peterson, Douglas W, Strand, Paul C, Marker, Chad M, Vezina
Publikováno v:
Am J Clin Exp Urol
Urinary voiding dysfunction in aging men can cause bothersome symptoms and irreparable tissue damage. Underlying mechanisms are not fully known. We previously demonstrated that subcutaneous, slow-release testosterone and estradiol implants (T+E2) dri
Autor:
Hannah Ruetten, Marlyse Wehber, Michael W. Wood, Michael F. Romero, Nelson T. Peterson, Chad M. Vezina, Nicholas M Girardi, Clara Cole, Dale E. Bjorling, Sara A. Colopy, Kyle A Wegner, Brandon R. Scharpf
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0232564 (2020)
PLoS ONE
PLoS ONE
BackgroundThe identity and spatial distribution of prostatic cell types has been determined in humans but not in dogs, even though aging- and prostate-related voiding disorders are common in both species and mechanistic factors, such as prostatic col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2028341f4e2e4d178db2dd5478615c10
Autor:
Alicia Malewska, Chad M. Vezina, Kyle A Wegner, Ryan Mauck, Diya B. Joseph, Douglas W. Strand, Claus G. Roehrborn, Jeff Reese, Ryan Hutchinson, Gervaise H. Henry, Jeffrey Gahan
Publikováno v:
Journal of Urology. 203
INTRODUCTION AND OBJECTIVE:Benign prostatic hyperplasia (BPH) is highly prevalent in aging men and poses a significant healthcare burden associated with the treatment of Lower Urinary Tract Symptom...