Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kyle A. Rasbach"'
Autor:
Brian A. Irving, Nicholas P. Greene, James P. White, Jennifer L. Estall, Kyle A. Rasbach, Brooke C. Harrison, Zhen Yan, Jun Wu, Kevin T. Brannan, Bruce M. Spiegelman, Leslie A. Leinwand, K. Sreekumaran Nair, Mitsuharu Okutsu, Rajesh R. Rao, Sandra Kleiner, Ian R. Lanza, Jorge L. Ruas
Publikováno v:
Cell. 151:1319-1331
PGC-1α is a transcriptional coactivator induced by exercise that gives muscle many of the best known adaptations to endurance-type exercise, but has no effects on muscle strength or hypertrophy. We have identified a novel form of PGC-1α (PGC-1α4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074d4da6465a9b1f8f184a07a82273ef
https://doi.org/10.1016/j.cell.2012.10.050
https://doi.org/10.1016/j.cell.2012.10.050
Autor:
Jennifer L. Estall, Jorge L. Ruas, Jun Wu, Elnaz Naseri, Rana K. Gupta, Bruce M. Spiegelman, Kyle A. Rasbach
Publikováno v:
Proceedings of the National Academy of Sciences. 107:21866-21871
The coactivator peroxisome proliferator-activated receptor-gamma coactivator 1 α (PGC-1α) coordinates a broad set of transcriptional programs that regulate the response of skeletal muscle to exercise. However, the complete transcriptional network c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd3662462ea9dfa391b14add7cd884b
https://doi.org/10.1073/pnas.1016089107
https://doi.org/10.1073/pnas.1016089107
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 332:632-639
Mitochondrial dysfunction is both a cause and target of reactive oxygen species during ischemia-reperfusion, drug, and toxicant injury. After injury, renal proximal tubular cells (RPTC) recover mitochondrial function by increasing the expression of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b3771038f1cd3ac6a66840ec18bfd3
https://doi.org/10.1124/jpet.109.159947
https://doi.org/10.1124/jpet.109.159947
Publikováno v:
American Journal of Physiology-Renal Physiology. 294:F459-F468
Our recent studies have shown that proliferation of renal proximal tubular cells (RPTC) in the absence of growth factors requires activation of the epidermal growth factor (EGF) receptor. We sought to identify the endogenous EGF receptor ligand and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7570c5603f8c5592218104379e33409f
https://doi.org/10.1152/ajprenal.00473.2007
https://doi.org/10.1152/ajprenal.00473.2007
Skeletal muscle atrophy remains a clinical problem in numerous pathologic conditions. β2-Adrenergic receptor agonists, such as formoterol, can induce mitochondrial biogenesis (MB) to prevent such atrophy. Additionally, atomoxetine, an FDA-approved n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8035db309ad1796f9cabb3fcd1da56bc
https://europepmc.org/articles/PMC4244586/
https://europepmc.org/articles/PMC4244586/
Autor:
Kyle A. Rasbach, Li Ye, Jang Hyun Choi, Shingo Kajimura, Bruce M. Spiegelman, Maria Cristina Zingaretti, Jun Wu, James C. Lo, Birgitte F. Vind, Pontus Boström, Steven P. Gygi, Mark P. Jedrychowski, Kurt Højlund, Hua Tu, Elisabeth A. Boström, Jonathan Z. Long, Saverio Cinti, Anisha Korde
Publikováno v:
Boström, P, Wu, J, Jedrychowski, M P, Korde, A, Ye, L, Lo, J C, Rasbach, K A, Boström, E A, Choi, J H, Long, J Z, Kajimura, S, Zingaretti, M C, Vind, B F, Tu, H, Cinti, S, Højlund, K, Gygi, S P & Spiegelman, B M 2012, ' A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis ', Nature, vol. 481, no. 7382, pp. 463-8 . https://doi.org/10.1038/nature10777
Nature
Nature
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we show in mouse that PGC1-α expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e793b111f2c349bf7e6a755817dee01
https://pubmed.ncbi.nlm.nih.gov/22932392
https://pubmed.ncbi.nlm.nih.gov/22932392
Autor:
Sina Odejinmi, Craig Beeson, David D. Arrington, Kyle A. Rasbach, Chris Giguere, Rick G. Schnellmann
Calpain 10 has been localized to the mitochondria and is a key mediator of Ca(2+) induced mitochondrial dysfunction. A peptide screen followed by a series of modifications identified the homodisulfide form of CYGAK (CYGAK)(2) as an inhibitor of calpa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62264ad8aeca5b241cd3734e9dcee9c3
https://europepmc.org/articles/PMC2801808/
https://europepmc.org/articles/PMC2801808/
Peroxisome proliferator activator receptor gamma coactivator 1alpha (PGC-1alpha) is a transcriptional coactivator known to mediate mitochondrial biogenesis. Whereas PGC-1alpha transcription is regulated by a variety of signaling cascades, the mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470bf9d03c5b54e58f119fc62ec046b4
https://europepmc.org/articles/PMC2846523/
https://europepmc.org/articles/PMC2846523/
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f69315470f55e5e971f5c326d55f4d7
https://doi.org/10.1096/fasebj.22.1_supplement.605.10
https://doi.org/10.1096/fasebj.22.1_supplement.605.10
Autor:
Kyle A. Rasbach, Rick G. Schnellmann
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 325(2)
Mitochondrial damage is often both the cause and outcome of cell injury resulting from a variety of toxic insults, hypoxia, or trauma. Increasing mitochondrial biogenesis after renal proximal tubular cell (RPTC) injury accelerated the recovery of mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39afe0e513222d7b4ac59b4b75bf1430
https://pubmed.ncbi.nlm.nih.gov/18267976
https://pubmed.ncbi.nlm.nih.gov/18267976