c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae

Autor: Kyle A. Floyd, Calvin K. Lee, Wujing Xian, Mahmoud Nametalla, Aneesa Valentine, Benjamin Crair, Shiwei Zhu, Hannah Q. Hughes, Jennifer L. Chlebek, Daniel C. Wu, Jin Hwan Park, Ali M. Farhat, Charles J. Lomba, Courtney K. Ellison, Yves V. Brun, Javier Campos-Gomez, Ankur B. Dalia, Jun Liu, Nicolas Biais, Gerard C. L. Wong, Fitnat H. Yildiz

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Biofilm formation by Vibrio cholerae is regulated by c-di-GMP and requires the type IV MSHA pilus. Here, Floyd et al. show that the MSHA pilus is a dynamic system, and that both extension and retraction are directly controlled by c-di-GMP via regulat

Externí odkaz: https://doaj.org/article/cabf8badabb34c2f9c45f7702f8ed372

Muscle Twitch Kinetics Are Dependent on Muscle Group, Disease State, and Age in Duchenne Muscular Dystrophy Mouse Models

Autor: Kyra K. Peczkowski, Neha Rastogi, Jeovanna Lowe, Kyle T. Floyd, Eric J. Schultz, Tallib Karaze, Jonathan P. Davis, Jill A. Rafael-Fortney, Paul M. L. Janssen

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

Duchenne muscular dystrophy (DMD) is an X-linked disorder caused by the lack of functional dystrophin protein. In muscular dystrophy preclinical research, it is pertinent to analyze the force of the muscles affected by the disease to assess pathology

Externí odkaz: https://doaj.org/article/c8bc92ca959e4908be273a42dd4c660c

Reciprocal c-di-GMP signaling: Incomplete flagellum biogenesis triggers c-di-GMP signaling pathways that promote biofilm formation.

Autor: Daniel C Wu, David Zamorano-Sánchez, Fernando A Pagliai, Jin Hwan Park, Kyle A Floyd, Calvin K Lee, Giordan Kitts, Christopher B Rose, Eric M Bilotta, Gerard C L Wong, Fitnat H Yildiz

Publikováno v: PLoS Genetics, Vol 16, Iss 3, p e1008703 (2020)

The assembly status of the V. cholerae flagellum regulates biofilm formation, suggesting that the bacterium senses a lack of movement to commit to a sessile lifestyle. Motility and biofilm formation are inversely regulated by the second messenger mol

Externí odkaz: https://doaj.org/article/af2ef7142989411ab50faab7a6c582c4

Nitric oxide stimulates type IV MSHA pilus retraction in

Autor: Hannah Q, Hughes, Kyle A, Floyd, Sajjad, Hossain, Sweta, Anantharaman, David T, Kysela, Miklόs, Zöldi, Lászlό, Barna, Yuanchen, Yu, Michael P, Kappler, Triana N, Dalia, Ram C, Podicheti, Douglas B, Rusch, Meng, Zhuang, Cassandra L, Fraser, Yves V, Brun, Stephen C, Jacobson, James B, McKinlay, Fitnat H, Yildiz, Elizabeth M, Boon, Ankur B, Dalia

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(7)

Bacteria use surface appendages called type IV pili to perform diverse activities including DNA uptake, twitching motility, and attachment to surfaces. The dynamic extension and retraction of pili are often required for these activities, but the stim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da1cc0cd9618bb671bef314485973b52
https://pubmed.ncbi.nlm.nih.gov/35135874

Roadmap on emerging concepts in the physical biology of bacterial biofilms:from surface sensing to community formation

Autor: Nikhil S. Malvankar, Kyle A. Floyd, Knut Drescher, Jing Yan, Yves V. Brun, Alexandre Persat, Haoran Xu, Jaime de Anda, Jörn Dunkel, Jyot D. Antani, Yilin Wu, Masanori Toyofuku, George A. O'Toole, Lori A. Zacharoff, Yutaka Yawata, Allon I. Hochbaum, Marco Kühn, Nobuhiko Nomura, Mohamed Y. El-Naggar, Roman Stocker, Gregory B. Whitfield, Sibel Ebru Yalcin, Ramin Golestanian, Francesco Carrara, Howard A. Stone, Calvin K. Lee, Pushkar P. Lele, Gerard C. L. Wong, Fitnat H. Yildiz, Ned S. Wingreen, Albert Siryaporn, Mauricio D. Rojas-Andrade, Jacinta C. Conrad, Shuai Yang, Jing Chen, Jean Louis Bru, Beiyan Nan, Bonnie L. Bassler, Fan Jin, Leo Eberl, Nina Molin Høyland-Kroghsbo, William C. Schmidt

Publikováno v: Wong, G C L, Antani, J D, Lele, P, Nan, B, Kühn, M J, Persat, A, Bru, J-L, Høyland-Kroghsbo, N M, Siryaporn, A, Conrad, J, Carrara, F, Yawata, Y, Stocker, R, Brun, Y, Whitfield, G, Lee, C, de Anda, J, Schmidt, W C, Golestanian, R, O'Toole, G A, Floyd, K, Yildiz, F, Yang, S, Jin, F, Toyofuku, M, Eberl, L, Nobuhiko, N, Zacharoff, L, El-Naggar, M Y, Yalcin, S E, Malvankar, N, Rojas-Andrade, M D, Hochbaum, A, Yan, J, Stone, H A, Wingreen, N S, Bassler, B, Wu, Y, Xu, H, Drescher, K & Dunkel, J 2021, ' Roadmap on emerging concepts in the physical biology of bacterial biofilms : from surface sensing to community formation ', Physical Biology, vol. 18, no. 5 . https://doi.org/10.1088/1478-3975/abdc0e
Physical Biology, 18 (5)

Bacterial biofilms are communities of bacteria that exist as aggregates that can adhere to surfaces or be free-standing. This complex, social mode of cellular organization is fundamental to the physiology of microbes and often exhibits surprising beh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fd0cf989701aca36eb0ec3785ae132
https://curis.ku.dk/ws/files/273580050/Wong_2021_Phys._Biol._18_051501.pdf