Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kyle DeFrees"'
Autor:
Michael D. Sacco, Kyle Defrees, Xiujun Zhang, William Lawless, Emeka Nwanochie, Amelia Balsizer, Sophie E. Darch, Adam R. Renslo, Yu Chen
Publikováno v:
ACS Infectious Diseases. 8:1231-1240
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebd16bd47f4ccf522664113f495b1eee
https://doi.org/10.1021/acsinfecdis.1c00650
https://doi.org/10.1021/acsinfecdis.1c00650
Autor:
Yu Chen, Adam R. Renslo, M. Trent Kemp, Insung Na, Xiujun Zhang, Kyle DeFrees, Derek A. Nichols
Publikováno v:
FEBS Letters. 595:2981-2994
The Asp233-Asp246 pair is highly conserved in Class A β-lactamases, which hydrolyze β-lactam antibiotics. Here, we characterize its function using CTX-M-14 β-lactamase. The D233N mutant displayed decreased activity that is substrate-dependent, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b7dcd70f060259df6f6764a170cf260
https://doi.org/10.1002/1873-3468.14215
https://doi.org/10.1002/1873-3468.14215
Autor:
Xochina ElHilali-Pollard, Kyle DeFrees, Adam R. Renslo, Ahmed Mohamed, M. Trent Kemp, Yu Chen, Xiujun Zhang
Publikováno v:
Org Chem Front
Compared to aryl–aryl π-stacking interactions, the analogous stacking of heteroarenes on amide π systems is less well understood and vastly underutilized in structure-based drug design. Recent theoretical studies have delineated the important geo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab1eac26518f79457586c760380e416
https://pubmed.ncbi.nlm.nih.gov/32774871
https://pubmed.ncbi.nlm.nih.gov/32774871
Autor:
Nicholas J. Torelli, Afroza Akhtar, Kyle DeFrees, Priyadarshini Jaishankar, Orville A. Pemberton, Xiujun Zhang, Cody Johnson, Adam R. Renslo, Yu Chen
Publikováno v:
ACS infectious diseases. 5(6)
Serine and metallo-carbapenemases are a serious health concern due to their capability to hydrolyze nearly all β-lactam antibiotics. However, the molecular basis for their unique broad-spectrum substrate profile is poorly understood, particularly fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb07bd6fb1dea7bf0922cf8e7ab4648
https://pubmed.ncbi.nlm.nih.gov/30942078
https://pubmed.ncbi.nlm.nih.gov/30942078
Autor:
Kyle DeFrees, K.K. Wang, H.L. Woodcock, Emmanuel W. Smith, Fabio Prati, Adam R. Renslo, Derek A. Nichols, Priyadarshini Jaishankar, Jacqueline C. Hargis, Yu Chen, Ruslan Sanishvili
Publikováno v:
Journal of the American Chemical Society, vol 137, iss 25
Ligand binding can change the pKa of protein residues and influence enzyme catalysis. Herein, we report three ultrahigh resolution X-ray crystal structures of CTX-M β-lactamase, directly visualizing protonation state changes along the enzymatic path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64c4f1029a7464ef880b3052ed1fb65
https://doi.org/10.1021/jacs.5b00749
https://doi.org/10.1021/jacs.5b00749
Autor:
David H. Thompson, Wei Deng, Aditya Kulkarni, Ross VerHeul, Ryan A. Schuldt, Seok-Hee Hyun, Kyle DeFrees, Alexander Vlahu
Publikováno v:
Integrative Biology. 5:115-121
A family of branched polyrotaxanes (bPRTx(+)), threaded with multiple cationic α-cyclodextrins (α-CDs) onto a multi-armed poly(ethylene glycol) (PEG) core, were synthesized and studied as gene silencing vectors. These bPRTx(+) formed stable, positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5174e8ae70ec015fcf85b33dc0c132
https://doi.org/10.1039/c2ib20107k
https://doi.org/10.1039/c2ib20107k
Autor:
Aditya Kulkarni, Ross VerHeul, Kyle DeFrees, David H. Thompson, Alexander Vlahu, Christopher J. Collins, Ryan A. Schuldt
Publikováno v:
Biomaterials science. 1(10)
Traditionally, transfection complexes are typically formed by bulk mixing, producing particles with high polydispersity and limited control over vector size. Herein, we demonstrate the use of a commercial micro-reactor to assemble pDNA:cationic cyclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e1f0ac6d5eb33833a7ab3833e0eed2
https://pubmed.ncbi.nlm.nih.gov/24349706
https://pubmed.ncbi.nlm.nih.gov/24349706
Autor:
Ryan A. Schuldt, David H. Thompson, Vivek D. Badwaik, Alexander Vlahu, Ross VerHeul, Aditya Kulkarni, Cory Powers, Kyle DeFrees, Dinara S. Gunasekera
Publikováno v:
Biomacromolecules. 15(1)
We have previously shown that cationic-β-cyclodextrin:R-poly(vinyl alcohol)-poly(ethylene glycol) (CD+:R-PVA-PEG) pendant polymer host:guest complexes are safe and efficient vehicles for nucleic acid delivery, where R = benzylidene-linked adamantyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367506862dc533a1a3cfbf124186079c
https://pubmed.ncbi.nlm.nih.gov/24295406
https://pubmed.ncbi.nlm.nih.gov/24295406
Autor:
Ross VerHeul, Kyle J. Wright, Charu K. Yerneni, Seok-Hee Hyun, Kyle DeFrees, Aditya Kulkarni, Ryan A. Schuldt, David H. Thompson
RNA interference has broad therapeutic potential due to its high specificity and ability to potentially evade drug resistance. Three cationic α-cyclodextrin:poly(ethylene glycol) polyrotaxanes derived from polymer axles of different sizes (MW 2,000,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2bd4a91f19f9ea00125096079d9c5d
https://europepmc.org/articles/PMC4083495/
https://europepmc.org/articles/PMC4083495/
A novel siRNA delivery vector has been developed, based on the self-assembly of mono-substituted cationic β-CD derivatives with a poly(vinyl alcohol)MW27kD (PVA) main chain polymer bearing poly(ethylene glycol)MW2000 (PEG) and acid-labile cholestero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6424380296e95bc7d095f632513cca0d
https://europepmc.org/articles/PMC6885381/
https://europepmc.org/articles/PMC6885381/