Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Kyle, Knox"'
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Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC) : an open-label, platform-adaptive randomised controlled trial
Autor: Christopher C Butler, F D Richard Hobbs, Oghenekome A Gbinigie, Najib M Rahman, Gail Hayward, Duncan B Richards, Jienchi Dorward, David M Lowe, Joseph F Standing, Judith Breuer, Saye Khoo, Stavros Petrou, Kerenza Hood, Jonathan S Nguyen-Van-Tam, Mahendra G Patel, Benjamin R Saville, Joe Marion, Emma Ogburn, Julie Allen, Heather Rutter, Nick Francis, Nicholas P B Thomas, Philip Evans, Melissa Dobson, Tracie-Ann Madden, Jane Holmes, Victoria Harris, May Ee Png, Mark Lown, Oliver van Hecke, Michelle A Detry, Christina T Saunders, Mark Fitzgerald, Nicholas S Berry, Lazaro Mwandigha, Ushma Galal, Sam Mort, Bhautesh D Jani, Nigel D Hart, Haroon Ahmed, Daniel Butler, Micheal McKenna, Jem Chalk, Layla Lavallee, Elizabeth Hadley, Lucy Cureton, Magdalena Benysek, Monique Andersson, Maria Coates, Sarah Barrett, Clare Bateman, Jennifer C Davies, Ivy Raymundo-Wood, Andrew Ustianowski, Andrew Carson-Stevens, Ly-Mee Yu, Paul Little, Akosua A Agyeman, Tanveer Ahmed, Damien Allcock, Adrian Beltran-Martinez, Oluseye E Benedict, Nigel Bird, Laura Brennan, Julianne Brown, Gerard Burns, Mike Butler, Zelda Cheng, Ruth Danson, Nigel de Kare-Silver, Devesh Dhasmana, Jon Dickson, Serge Engamba, Stacey Fisher, Robin Fox, Eve Frost, Richard Gaunt, Sarit Ghosh, Ishtiaq Gilkar, Anna Goodman, Steve Granier, Aleksandra Howell, Iqbal Hussain, Simon Hutchinson, Marie Imlach, Greg Irving, Nicholas Jacobsen, James Kennard, Umar Khan, Kyle Knox, Christopher Krasucki, Tom Law, Rem Lee, Nicola Lester, David Lewis, James Lunn, Claire I. Mackintosh, Mehul Mathukia, Patrick Moore, Seb Morton, Daniel Murphy, Rhiannon Nally, Chinonso Ndukauba, Olufunto Ogundapo, Henry Okeke, Amit Patel, Kavil Patel, Ruth Penfold, Satveer Poonian, Olajide Popoola, Alexander Pora, Vibhore Prasad, Rishabh Prasad, Omair Razzaq, Scot Richardson, Simon Royal, Afsana Safa, Satash Sehdev, Tamsin Sevenoaks, Divya Shah, Aadil Sheikh, Vanessa Short, Baljinder S Sidhu, Ivor Singh, Yusuf Soni, Chris Thalasselis, Pete Wilson, David Wingfield, Michael Wong, Maximillian N J Woodall, Nick Wooding, Sharon Woods, Joanna Yong, Francis Yongblah, Azhar Zafar
Publikováno v: PANORAMIC Trial Collaborative Group, Butler, C C, Hobbs, F D R, Gbinigie, O A, Rahman, N M, Hayward, G, Richards, D B, Dorward, J, Lowe, D M, Standing, J F, Breuer, J, Khoo, S, Petrou, S, Hood, K, Nguyen-Van-Tam, J S, Patel, M G, Saville, B R, Marion, J, Ogburn, E, Allen, J, Rutter, H, Francis, N, Thomas, N P B, Evans, P, Dobson, M, Madden, T-A, Holmes, J, Harris, V, Png, M E, Lown, M, van Hecke, O, Detry, M A, Saunders, C T, Fitzgerald, M, Berry, N S, Mwandigha, L, Galal, U, Mort, S, Jani, B D, Hart, N D, Ahmed, H, Butler, D, McKenna, M, Chalk, J, Lavallee, L, Hadley, E, Cureton, L, Benysek, M, Andersson, M, Coates, M & Barrett, S 2023, ' Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial ', The Lancet, vol. 401, no. 10373, pp. 281-293 . https://doi.org/10.1016/S0140-6736(22)02597-1
Background The safety, effectiveness, and cost-effectiveness of molnupiravir, an oral antiviral medication for SARS-CoV-2, has not been established in vaccinated patients in the community at increased risk of morbidity and mortality from COVID-19. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6937dbf90341fd2ff687fe41c3d612
https://hdl.handle.net/10023/27412
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3
Akademický článek
Within-host evolution of Staphylococcus aureus during asymptomatic carriage.
Autor: Tanya Golubchik, Elizabeth M Batty, Ruth R Miller, Helen Farr, Bernadette C Young, Hanna Larner-Svensson, Rowena Fung, Heather Godwin, Kyle Knox, Antonina Votintseva, Richard G Everitt, Teresa Street, Madeleine Cule, Camilla L C Ip, Xavier Didelot, Timothy E A Peto, Rosalind M Harding, Daniel J Wilson, Derrick W Crook, Rory Bowden
Publikováno v: PLoS ONE, Vol 8, Iss 5, p e61319 (2013)
BackgroundStaphylococcus aureus is a major cause of healthcare associated mortality, but like many important bacterial pathogens, it is a common constituent of the normal human body flora. Around a third of healthy adults are carriers. Recent evidenc
Externí odkaz: https://doaj.org/article/ceaa09b68e7541248844928c570fc942
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4
Predictors of Adverse Outcomes in Uncomplicated Lower Respiratory Tract Infections
Autor: Ann Van den Bruel, Paul Little, Matthew Thompson, Mark Lown, Kyle Knox, Susan M Smith, Michael Moore, Beth Stuart
PURPOSE: Presentation with acute lower respiratory tract infection (LRTI) in primary care is common. The aim of this study was to help clinicians treat patients presenting with LRTI in primary care by identifying those at risk of serious adverse outc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5417352412d324e5eecd8681fd7b6c55
https://lirias.kuleuven.be/handle/123456789/649505
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6
Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4):an unmasked randomised controlled trial
Autor: Richard J McManus, Jonathan Mant, Marloes Franssen, Alecia Nickless, Claire Schwartz, James Hodgkinson, Peter Bradburn, Andrew Farmer, Sabrina Grant, Sheila M Greenfield, Carl Heneghan, Susan Jowett, Una Martin, Siobhan Milner, Mark Monahan, Sam Mort, Emma Ogburn, Rafael Perera-Salazar, Syed Ahmar Shah, Ly-Mee Yu, Lionel Tarassenko, F D Richard Hobbs, Brendan Bradley, Chris Lovekin, David Judge, Luis Castello, Maureen Dawson, Rebecca Brice, Bethany Dunbabin, Sophie Maslen, Heather Rutter, Mary Norris, Lauren French, Michael Loynd, Pippa Whitbread, Luisa Saldana Ortaga, Irene Noel, Karen Madronal, Julie Timmins, Lucy Hughes, Beth Hinks, Sheila Bailey, Sue Read, Andrea Weston, Somi Spannuth, Sue Maiden, Makiko Chermahini, Ann McDonald, Shelina Rajan, Sue Allen, Brenda Deboys, Kim Fell, Jenny Johnson, Helen Jung, Rachel Lister, Ruth Osborne, Amy Secker, Irene Qasim, Kirsty William, Abi Harris, Susan Zhao, Elaine Butcher, Pauline Darbyshire, Sarah Joshi, Jon Davies, Claire Talbot, Eleanor Hoverd, Linda Field, Tracey Adcock, Julia Rooney, Nina Cooter, Aaron Butler, Naomi Allen, Maria Abdul-Wahab, Kathryn McNicholas, Lara Peniket, Kate Dodd, Julie Mugurza, Richard Baskerville, Rakshan Syed, Clare Bailey, Jill Adams, Paul Uglow, Neil Townsend, Alison Macleod, Charlotte Hawkins, Suparna Behura, Jonathan Crawshaw, Robin Fox, Waleed Doski, Martin Aylward, Christine A'Court, David Rapley, Jo Walsh, Paul Batra, Ana Seoane, Sluti Mukherjee, Jonathan Dixon, Peter Arthur, Karen Sutcliffe, Costas Paschallides, Richard Woof, Peter Winfrey, Matthew Clark, Roya Kamali, Paul Thomas, David Ebbs, Liz Mather, Andre Beattie, Karim Ladha, Larisa Smondulak, Surinder Jemahl, Peter Hickson, Liam Stevens, Tony Crockett, David Shukla, Ian Binnian, Paul Vinson, Nigel DeKare-Silver, Ramila Patel, Ivor Singh, Louise Lumley, Glennis Williams, Mark Webb, Jack Bambrough, Neetul Shah, Hergeven Dosanjh, Frank Spannuth, Carolyn Paul, Jude Ganesegaram, Laurie Pike, Vijaysundari Maheswaran, Farah Paruk, Stephen Ford, Vineeta Verma, Kate Milne, Farhana Lockhat, Jennifer Ferguson, Anne-Marie Quirk, Hugo Wilson, David Copping, Sam Bajallan, Simria Tanvir, Faheem Khan, Tom Alderson, Amar Ali, Richard Young, Umesh Chauhan, Lindsey Crockett, Louise McGovern, Claire Cubitt, Simon Weatherill, Abdul Tabassum, Philip Saunders, Naresh Chauhan, Samantha Johnson, Inderjit Marok, Rajiv Sharma, William Lumb, John Tweedale, Ian Smith, Lawrence Miller, Tanveer Ahmed, Mark Sanderson, Claire Jones, Peter Stokell, Matthew J Edwards, Andrew Askey, Jason Spencer, Kathryn Morgan, Kyle Knox, Robert Baker, Crispin Fisher, Rachel Halstead, Neil Modha, David Buckley, Catherine Stokell, John Gerald McCabe, Jennifer Taylor, Helen Nutbeam, Richard Smith, Christopher MacGregor, Sam Davies, Mark Lindsey, Simon Cartwright, Jonathan Whittle, Julie Colclough, Alison Crumbie, Nicholas Thomas, Vattakkatt Premchand, Rafia Hamid, Zishan Ali, John Ward, Philip Pinney, Stephen Thurston, Tina Banerjee
Publikováno v: McManus, R, Mant, J, Franssen, M, Nickless, A, Schwartz, C, Hodgkinson, J A, Bradburn, P, Grant, S, Farmer, A, Greenfield, S, Heneghan, C, Jowett, S, Martin, U, Milner, S L, Monahan, M, Mort, S, Ogburn, E, Perera-Salazar, R, Shah, S, Yu, L-M, Tarassenko, L, Hobbs, F D R 2018, ' Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4) : an unmasked randomised controlled trial ', Lancet, vol. 391, no. 10124, pp. 949-959 . https://doi.org/10.1016/S0140-6736(18)30309-X
Lancet (London, England)
McManus, R J, Mant, J, Franssen, M, Nickless, A, Schwartz, C, Hodgkinson, J, Bradburn, P, Farmer, A, Grant, S, Greenfield, S M, Heneghan, C, Jowett, S, Martin, U, Milner, S, Monahan, M, Mort, S, Ogburn, E, Perera-Salazar, R, Shah, S A, Yu, L-M & Tarassenko, L & Hobbs, F D R 2018, ' Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4): an unmasked randomised controlled trial ', The Lancet, vol. 391, no. 10124, pp. 949-959 . https://doi.org/10.1016/S0140-6736(18)30309-X
BACKGROUND: Studies evaluating titration of antihypertensive medication using self-monitoring give contradictory findings and the precise place of telemonitoring over self-monitoring alone is unclear. The TASMINH4 trial aimed to assess the efficacy o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b898623766880e2558662bb61e2c8be
https://research-information.bris.ac.uk/ws/files/150873850/PIIS0140_6736_18_30309_X.pdf
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7
Predictors of pneumonia in lower respiratory tract infections: 3C prospective cough complication cohort study
Autor: Paul Little, Anne van den Bruel, Matthew Thompson, Sue Erica Smith, Beth Stuart, Michael Moore, Kyle Knox, Mark Lown, David Mant
Publikováno v: The European Respiratory Journal
The aim was to aid diagnosis of pneumonia in those presenting with lower respiratory tract symptoms in routine primary care. A cohort of 28 883 adult patients with acute cough attributed to lower respiratory tract infections (LRTIs) was recruited fro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa235a609f24dd004a64a5fc7b147973
https://lirias.kuleuven.be/handle/20.500.12942/715297
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8
Antibiotic prescription strategies and adverse outcome for uncomplicated lower respiratory tract infections: prospective cough complication cohort (3C) study
Autor: Ann Van den Bruel, Mark Lown, Michael Moore, Kyle Knox, Susan M Smith, Paul Little, David Mant, Beth Stuart, Matthew Thompson
Publikováno v: BMJ (Clinical research ed.). 357
Objective To assess the impact on adverse outcomes of different antibiotic prescribing strategies for lower respiratory tract infections in people aged 16 years or more.Design Prospective cohort study.Setting UK general practice.Participants 28 883 p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb69b12be7f44738d904e97636400af
https://pubmed.ncbi.nlm.nih.gov/28533355
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9
Opioid analgesic dependence: where do we go from here?
Autor: Jane Quinlan, Farrukh Alam, Kyle Knox
The British Medical Association has recently produced recommendations for the support of people with prescribed drug dependence.1 Their focus is appropriately broad, addressing benzodiazepines, antidepressants and opioids, with three main themes for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09a2ae22d9eb4239ad68f097d3c9bf0
https://ora.ox.ac.uk/objects/uuid:b6092cb8-3164-49f2-af16-e57a5016a404
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10
MBL genotype and risk of invasive pneumococcal disease: a case-control study
Autor: Alexander K. Smárason, David Griffiths, Catrin E. Moore, William L. McPheat, Shelley Segal, Derrick W. Crook, Nicholas P. J. Day, Adrian V. S. Hill, Kyle Knox, S. Roy, Kenneth I. Welsh
Summary Background Streptococcus pneumonias is a major cause of morbidity and mortality in developed and developing countries. No common genetic determinants of susceptibility have been defined. Mannose-binding lectin (MBL) is a key mediator of innat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31dbb18283dc8611517aa01adcd4ec6
https://doi.org/10.1016/s0140-6736(02)08516-1
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