Investigation of Naphthyl–Polyamine Conjugates as Antimicrobials and Antibiotic Enhancers

Autor: Melissa M. Cadelis, Liam R. Edmeades, Dan Chen, Evangelene S. Gill, Kyle Fraser, Florent Rouvier, Marie-Lise Bourguet-Kondracki, Jean Michel Brunel, Brent R. Copp

Publikováno v: Antibiotics, Vol 12, Iss 6, p 1014 (2023)

As part of our search for new antimicrobials and antibiotic enhancers, a series of naphthyl- and biphenyl-substituted polyamine conjugates have been synthesized. The structurally-diverse library of compounds incorporated variation in the capping end

Externí odkaz: https://doaj.org/article/e9ac8a95b359490d9a748abe85c237c6

Exploration of Bis-Cinnamido-Polyamines as Intrinsic Antimicrobial Agents and Antibiotic Enhancers

Autor: Copp, Melissa M. Cadelis, Jisoo Kim, Florent Rouvier, Evangelene S. Gill, Kyle Fraser, Marie-Lise Bourguet-Kondracki, Jean Michel Brunel, Brent R.

Publikováno v: Biomolecules; Volume 13; Issue 7; Pages: 1087

The marine natural product ianthelliformisamine C is a bis-cinnamido substituted spermine derivative that exhibits intrinsic antimicrobial properties and can enhance the action of doxycycline towards the Gram-negative bacterium Pseudomonas aeruginosa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::b1bfb93b02fb97fe15ef6b3b3a4393e4

Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity

Autor: Aron Gyuris, Jose Navarrete-Perea, Ala Jo, Simona Cristea, Shuang Zhou, Kyle Fraser, Zhiyun Wei, Anna M. Krichevsky, Ralph Weissleder, Hakho Lee, Steve P. Gygi, Al Charest

Publikováno v: Cell Reports, Vol 27, Iss 13, Pp 3972-3987.e6 (2019)

Summary: Cancer extracellular vesicles (EVs) are highly heterogeneous, which impedes our understanding of their function as intercellular communication agents and biomarkers. To deconstruct this heterogeneity, we analyzed extracellular RNAs (exRNAs)

Externí odkaz: https://doaj.org/article/5034af0a55cc44c5902e50df63b76e17

Concordance of CSF biomarkers with amyloid PET at baseline in EMERGE/ENGAGE, phase 3 studies of aducanumab in patients with early Alzheimer’s disease

Autor: Carrie E. Rubel, Laura Nisenbaum, Tianle Chen, Gersham Dent, Kyle Fraser, Danielle Graham, Katie Harrison, Ping He, Annie M Racine, Raj Rajagovindan, John Beaver, Samantha Budd Haeberlein

Publikováno v: Alzheimer's & Dementia. 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d296f438d4800a0120c4af9c592aed72
https://doi.org/10.1002/alz.069382

Trial of Cinpanemab in Early Parkinson's Disease

Autor: Anthony E, Lang, Andrew D, Siderowf, Eric A, Macklin, Werner, Poewe, David J, Brooks, Hubert H, Fernandez, Olivier, Rascol, Nir, Giladi, Fabrizio, Stocchi, Caroline M, Tanner, Ronald B, Postuma, David K, Simon, Eduardo, Tolosa, Brit, Mollenhauer, Jesse M, Cedarbaum, Kyle, Fraser, James, Xiao, Karleyton C, Evans, Danielle L, Graham, Inbal, Sapir, Jennifer, Inra, R Matthew, Hutchison, Minhua, Yang, Tara, Fox, Samantha, Budd Haeberlein, Tien, Dam, Laurice, Yang

Publikováno v: Lang, A E, Siderowf, A D, Macklin, E A, Poewe, W, Brooks, D J, Fernandez, H H, Rascol, O, Giladi, N, Stocchi, F, Tanner, C M, Postuma, R B, Simon, D K, Tolosa, E, Mollenhauer, B, Cedarbaum, J M, Fraser, K, Xiao, J, Evans, K C, Graham, D L, Sapir, I, Inra, J, Hutchison, R M, Yang, M, Fox, T, Budd Haeberlein, S, Dam, T & SPARK Investigators 2022, ' Trial of Cinpanemab in Early Parkinson's Disease ', The New England Journal of Medicine, vol. 387, no. 5, pp. 408-420 . https://doi.org/10.1056/NEJMoa2203395

BACKGROUND: Aggregated α-synuclein plays an important role in Parkinson's disease pathogenesis. Cinpanemab, a human-derived monoclonal antibody that binds to α-synuclein, is being evaluated as a disease-modifying treatment for Parkinson's disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b50a6abc4d9ecccdef2d7c021fbbee6
https://pubmed.ncbi.nlm.nih.gov/35921450