Výsledky vyhledávání - "Kyla M. Smith"

HPLC reveals novel features of nucleoside and nucleobase homeostasis, nucleoside metabolism and nucleoside transport

Autor: Reema A. Altaweraqi, Sylvia Y.M. Yao, James D. Young, Kyla M. Smith, Carol E. Cass

Publikováno v: Biochimica et biophysica acta. Biomembranes. 1862(7)

Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a1298cae1c58057a974fbfcca7ef35
https://pubmed.ncbi.nlm.nih.gov/32126230

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Interaction of fused-pyrimidine nucleoside analogs with human concentrative nucleoside transporters: High-affinity inhibitors of human concentrative nucleoside transporter 1

Autor: Ireneusz Nowak, Carol E. Cass, James D. Young, Edward Karpinski, Delores Mowles, Vijaya L. Damaraju, Kyla M. Smith, Morris J. Robins

Publikováno v: Biochemical Pharmacology. 81:82-90

Human concentrative nucleoside transporters (hCNTs) mediate electrogenic secondary active transport of physiological nucleosides and nucleoside drugs into cells. Six fused-pyrimidine ribonucleosides and one 2'-deoxynucleoside were assessed for their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b69eea87905d7c62b8afb2c8104779
https://doi.org/10.1016/j.bcp.2010.09.009

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Conserved Glutamate Residues Glu-343 and Glu-519 Provide Mechanistic Insights into Cation/Nucleoside Cotransport by Human Concentrative Nucleoside Transporter hCNT3

Autor: Edward Karpinski, Sylvia Y.M. Yao, Kyla M. Smith, James D. Young, Melissa D. Slugoski, Carol E. Cass, Stephen A. Baldwin, Amy M. L. Ng

Publikováno v: Journal of Biological Chemistry. 284:17266-17280

Human concentrative nucleoside transporter 3 (hCNT3) utilizes electrochemical gradients of both Na(+) and H(+) to accumulate pyrimidine and purine nucleosides within cells. We have employed radioisotope flux and electrophysiological techniques in com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2dd1cca357cc154605c3ad034d1c3d
https://doi.org/10.1074/jbc.m109.009613

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A Conformationally Mobile Cysteine Residue (Cys-561) Modulates Na+ and H+ Activation of Human CNT3

Autor: Amy M. L. Ng, Queenie O.T. Lee, Edward Karpinski, Stephen A. Baldwin, Ras Mulinta, Ellen Morrison, Jing Zhang, Sylvia Y.M. Yao, Kyla M. Smith, Melissa D. Slugoski, James D. Young, Carol E. Cass

Publikováno v: Journal of Biological Chemistry. 283:24922-24934

In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80cdb4ac22ccf96b78b10b4b422c174
https://doi.org/10.1074/jbc.m801793200

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Conserved Glutamate Residues Are Critically Involved in Na+/Nucleoside Cotransport by Human Concentrative Nucleoside Transporter 1 (hCNT1)

Autor: Stephen A. Baldwin, Amy M. L. Ng, James D. Young, Edward Karpinski, Melissa D. Slugoski, Sylvia Y.M. Yao, Carol E. Cass, Ras Mulinta, Kyla M. Smith

Publikováno v: Journal of Biological Chemistry. 282:30607-30617

Human concentrative nucleoside transporter 1 (hCNT1), the first discovered of three human members of the SLC28 (CNT) protein family, is a Na+/nucleoside cotransporter with 650 amino acids. The potential functional roles of 10 conserved aspartate and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8da15e34d2ee55d8c7010d27454fc3a
https://doi.org/10.1074/jbc.m703285200

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Specific Mutations in Transmembrane Helix 8 of Human Concentrative Na+/Nucleoside Cotransporter hCNT1 Affect Permeant Selectivity and Cation Coupling

Autor: Edward Karpinski, James D. Young, Amy M. L. Ng, Sylvia Y.M. Yao, Stephen A. Baldwin, Carol E. Cass, Shaun K. Loewen, Kyla M. Smith, Melissa D. Slugoski

Publikováno v: Biochemistry. 46:1684-1693

The Na + /nudeoside cotransporters hCNT1 (650 residues) and hCNT2 (658 residues) are 72% identical in amino acid sequence and contain 13 putative transmembrane helices (TMs). Both transport uridine and adenosine but are otherwise selective for pyrimi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a70457f8c615e52adcdf79e4eb5d89c
https://doi.org/10.1021/bi061692s

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The Role of Human Nucleoside Transporters in Cellular Uptake of 4′-Thio-β-d-arabinofuranosylcytosine and β-d-Arabinosylcytosine

Autor: Jing Zhang, James D. Young, Tracey Tackaberry, Carol E. Cass, Delores Mowles, Thach Lang, Blake Tomkinson, Marilyn L Clarke, Vijaya L. Damaraju, Kyla M. Smith

Publikováno v: Molecular Pharmacology. 70:303-310

4'-Thio-beta-D-arabinofuranosyl cytosine (TaraC) is in phase I development for treatment of cancer. In human equilibrative nucleoside transporter (hENT) 1-containing CEM cells, initial rates of uptake (10 microM; picomoles per microliter of cell wate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda5bf1447c84198ea60c4d86d9792b0
https://doi.org/10.1124/mol.105.021543

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Uridine Binding and Transportability Determinants of Human Concentrative Nucleoside Transporters

Autor: Jing Zhang, Carol E. Cass, Ireneusz Nowak, Stephen A. Baldwin, Edward Karpinski, Lars P. C. Nielsen, Kyla M. Smith, Morris J. Robins, James D. Young, Tracey Tackaberry, Frank Visser

Publikováno v: Molecular Pharmacology. 68:830-839

Human concentrative nucleoside transporters 1, 2, and 3 (hCNT1, hCNT2, and hCNT3) exhibit different functional characteristics, and a better understanding of their permeant selectivities is critical for development of nucleoside analog drugs with opt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5bf00b6e44e531c3dda9227ed366ff
https://doi.org/10.1124/mol.105.012187

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Electrophysiological characterization of a recombinant human Na+-coupled nucleoside transporter (hCNT1) produced inXenopusoocytes

Autor: Edward Karpinski, Xing-Zhen Chen, Amy M. L. Ng, Kyla M. Smith, Kathy A. Labedz, Leonard I. Wiebe, Edward E. Knaus, Sylvia Y.M. Yao, Stephen A. Baldwin, Carol E. Cass, James D. Young

Publikováno v: The Journal of Physiology. 558:807-823

Physiological nucleosides and nucleoside analogues have important biochemical, physiological and pharmacological activities in humans. Adenosine, for example, has cell-surface receptor-mediated functions in processes such as modulation of immune resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8da5aed05d7b4ff0cc56d9a23f31c043
https://doi.org/10.1113/jphysiol.2004.068189

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Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1

Autor: Carol E. Cass, Kwan H. Leung, Jing Zhang, James D. Young, Vijaya L. Damaraju, Wendy P. Gati, Kyla M. Smith, Sylvia Y.M. Yao, Edward Karpinski, Eve-Irene Lepist

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 41(4)

The high density of A1 adenosine receptors in the brain results in significant potential for central nervous system (CNS)-related adverse effects with A1 agonists. Tecadenoson is a selective A1 adenosine receptor agonist with close similarity to aden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89605b91f8724c22b9bcc6e8745e116
https://pubmed.ncbi.nlm.nih.gov/23388705

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