Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kyla M Grimshaw"'
Autor:
Jeffrey J Wallin, Jane Guan, Kyle A Edgar, Wei Zhou, Ross Francis, Anthony C Torres, Peter M Haverty, Jeffrey Eastham-Anderson, Sabrina Arena, Alberto Bardelli, Sue Griffin, John E Goodall, Kyla M Grimshaw, Klaus P Hoeflich, Christopher Torrance, Marcia Belvin, Lori S Friedman
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36402 (2012)
The PTEN/PI3K pathway is commonly mutated in cancer and therefore represents an attractive target for therapeutic intervention. To investigate the primary phenotypes mediated by increased pathway signaling in a clean, patient-relevant context, an act
Externí odkaz:
https://doaj.org/article/64952bf9ee0a4f75af0606c666386285
Autor:
Michelle D. Garrett, Neil T. Thompson, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, John F. Lyons, Thomas G. Davies, Steven J. Woodhead, Matthias Reule, Ruth E. Feltell, Paul S. Jones, Kathrin Heinzmann, Simon P. Heaton, Anna Zetterlund, Vanessa Martins, Alexis K. de Haven Brandon, Melanie R. Valenti, Paul D. Eve, Robert H. te Poele, Kyla M. Grimshaw, Mike I. Walton, Timothy A. Yap
PDF file - 81K, Supplementary data comprising the materials and methods for (i) crystallography (ii) gene expression studies (iii) siRNA studies and Supplementary Figure legends 1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136ef480c6dff64c10335140171ee9da
https://doi.org/10.1158/1078-0432.22446023.v1
https://doi.org/10.1158/1078-0432.22446023.v1
Autor:
Michelle D. Garrett, Neil T. Thompson, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, John F. Lyons, Thomas G. Davies, Steven J. Woodhead, Matthias Reule, Ruth E. Feltell, Paul S. Jones, Kathrin Heinzmann, Simon P. Heaton, Anna Zetterlund, Vanessa Martins, Alexis K. de Haven Brandon, Melanie R. Valenti, Paul D. Eve, Robert H. te Poele, Kyla M. Grimshaw, Mike I. Walton, Timothy A. Yap
XLS file - 703K, Gene expression data for CCT128930: Genes that showed at least a 1.5 Fold Change in at least one treated sample compared to vehicle control and were differentially expressed between the treatment groups (Welch ANOVA FDR5%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264e5ae7347bb9dfece9541b75115729
https://doi.org/10.1158/1078-0432.22446017.v1
https://doi.org/10.1158/1078-0432.22446017.v1
Autor:
Michelle D. Garrett, Neil T. Thompson, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, John F. Lyons, Thomas G. Davies, Steven J. Woodhead, Matthias Reule, Ruth E. Feltell, Paul S. Jones, Kathrin Heinzmann, Simon P. Heaton, Anna Zetterlund, Vanessa Martins, Alexis K. de Haven Brandon, Melanie R. Valenti, Paul D. Eve, Robert H. te Poele, Kyla M. Grimshaw, Mike I. Walton, Timothy A. Yap
Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73dad559501b49bb682286db9d7d443d
https://doi.org/10.1158/1078-0432.c.6520622
https://doi.org/10.1158/1078-0432.c.6520622
Autor:
Michelle D. Garrett, Neil T. Thompson, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, John F. Lyons, Thomas G. Davies, Steven J. Woodhead, Matthias Reule, Ruth E. Feltell, Paul S. Jones, Kathrin Heinzmann, Simon P. Heaton, Anna Zetterlund, Vanessa Martins, Alexis K. de Haven Brandon, Melanie R. Valenti, Paul D. Eve, Robert H. te Poele, Kyla M. Grimshaw, Mike I. Walton, Timothy A. Yap
XLS file - 66K, Genes that showed at least a 1.5 Fold Change in at least one treated sample compared to vehicle control and were differentially expressed between the treatment groups (Welch ANOVA FDR5%) for both CCT128930 and AT13148
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02505457843f17ab3c7bd679c87ef577
https://doi.org/10.1158/1078-0432.22446008
https://doi.org/10.1158/1078-0432.22446008
Autor:
Michelle D. Garrett, Neil T. Thompson, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, John F. Lyons, Thomas G. Davies, Steven J. Woodhead, Matthias Reule, Ruth E. Feltell, Paul S. Jones, Kathrin Heinzmann, Simon P. Heaton, Anna Zetterlund, Vanessa Martins, Alexis K. de Haven Brandon, Melanie R. Valenti, Paul D. Eve, Robert H. te Poele, Kyla M. Grimshaw, Mike I. Walton, Timothy A. Yap
PDF file - 553K, Supplementary Figure 1. Phosphorylation of AKT substrates remains suppressed, despite pSer473 AKT induction. Supplementary Figure 2. The pharmacokinetic-pharmacodynamic profile and antitumor activity of AT13148 in PTEN-deficient PC3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66309a130e6558ca6307e2e123bca36e
https://doi.org/10.1158/1078-0432.22446026
https://doi.org/10.1158/1078-0432.22446026
Autor:
Lori Friedman, Kyla M. Grimshaw, Sabrina Arena, Anthony C. Torres, Alberto Bardelli, Jeffrey Eastham-Anderson, Christopher Torrance, Peter M. Haverty, Sue Griffin, Jeffrey Wallin, Klaus P. Hoeflich, Kyle A. Edgar, Marcia Belvin, Jane Guan, John Goodall, Wei Zhou, Ross Francis
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 5, p e36402 (2012)
PLoS ONE, Vol 7, Iss 5, p e36402 (2012)
The PTEN/PI3K pathway is commonly mutated in cancer and therefore represents an attractive target for therapeutic intervention. To investigate the primary phenotypes mediated by increased pathway signaling in a clean, patient-relevant context, an act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99983aee837900ddc9550577d8ea4479
http://europepmc.org/articles/PMC3343052
http://europepmc.org/articles/PMC3343052