IGF1R is an entry receptor for respiratory syncytial virus

Autor: Cameron D. Griffiths, Anil Kumar, Tom C. Hobman, Lionel D. Jensen, John E. McDonough, Jean-Laurent Casanova, Leanne M. Bilawchuk, David Proud, Theo J. Moraes, Steven Ogg, Bernard Thienpont, Yuchen Cen, Haeun Song, David J. Marchant, Wenming Duan, Cindy Lin, Farah Elawar, Kyla C. Jamieson

Publikováno v: Nature. 583:615-619

Pneumonia resulting from infection is one of the leading causes of death worldwide. Pulmonary infection by the respiratory syncytial virus (RSV) is a large burden on human health, for which there are few therapeutic options1. RSV targets ciliated epi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9dfe6b7bb61f93645682f171e0f652ae
https://doi.org/10.1038/s41586-020-2369-7

Analysis of the Indacaterol-Regulated Transcriptome in Human Airway Epithelial Cells Implicates Gene Expression Changes in the Adverse and Therapeutic Effects ofβ2-Adrenoceptor Agonists

Autor: Radhika Joshi, Kyla C. Jamieson, Mahmoud M. Mostafa, Mark A. Giembycz, Robert Newton, Dong Yan, Taruna Joshi, Omar Hamed

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 366:220-236

The contribution of gene expression changes to the adverse and therapeutic effects of β2-adrenoceptor agonists in asthma was investigated using human airway epithelial cells as a therapeutically relevant target. Operational model-fitting established

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01ea93ed88a7a1bca0fe081272c5c3af
https://doi.org/10.1124/jpet.118.249292

IGF1R is an entry receptor for respiratory syncytial virus

Autor: Cameron D, Griffiths, Leanne M, Bilawchuk, John E, McDonough, Kyla C, Jamieson, Farah, Elawar, Yuchen, Cen, Wenming, Duan, Cindy, Lin, Haeun, Song, Jean-Laurent, Casanova, Steven, Ogg, Lionel Dylan, Jensen, Bernard, Thienpont, Anil, Kumar, Tom C, Hobman, David, Proud, Theo J, Moraes, David J, Marchant

Publikováno v: Nature. 583(7817)

Pneumonia resulting from infection is one of the leading causes of death worldwide. Pulmonary infection by the respiratory syncytial virus (RSV) is a large burden on human health, for which there are few therapeutic options

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a37ff3d8dd9d3b0b599a0764f3e5c3ae
https://pubmed.ncbi.nlm.nih.gov/32555542

Rhinovirus and Bacteria Synergistically Induce IL-17C Release from Human Airway Epithelial Cells To Promote Neutrophil Recruitment

Autor: David Proud, Barbara A. Maciejewski, Aubrey N. Michi, Shahina Wiehler, Richard Leigh, Jason Arnason, Cora Kooi, Kyla C. Jamieson, Suzanne L. Traves, Curtis Dumonceaux

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 202(1)

Virus–bacteria coinfections are associated with more severe exacerbations and increased risk of hospital readmission in patients with chronic obstructive pulmonary disease (COPD). The airway epithelium responds to such infections by releasing proin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5b0984379e3d5fa9886188bef7983f
https://pubmed.ncbi.nlm.nih.gov/30504421

AllerGen’s 8th research conference

Autor: Gail M. Gauvreau, Edward M. Conway, Casey P. Shannon, Susan J. Elliott, Marie-Claire Arrieta, Minglian Jin, J. Mark FitzGerald, Susan Goruk, Danuta Radzioch, Lisa M. Steacy, Young Woong Kim, Mark W. Tenn, Jeffrey R. Brook, Bingqing Shen, Abbey Schlatman, David Dai, Karen Howie, William H. Dow, David Proud, Manjeet Kumari, Chan Young Park, Kelly Sabaliauskas, Felix Ratjen, Gurpreet K. Singhera, Allan B. Becker, Cynthia Kanagaratham, Sarah De Schryver, Neeloffer Mookherjee, Frances Coates, Angela Chow, Christopher J. Olesovsky, P. J. Cooper, Helen Neighbour, Michael O'Sullivan, Darren Sutherland, Sarah L. Bridgman, Moshe Ben-Shoshan, Olga M. Pena, Anick Langlois, Duncan Lejtenyi, Cheng Peng, Vanessa Nieratschker, Tim K. Takaro, Maxwell M. Tran, Emilie Bernatchez, Theodore Konya, Jordan Brubacher, Melanie Emmerson, Edith Chen, Matthew J. Gold, Larry D. Lynd, Mohsen Sadatsafavi, Jens Walter, Bob Hancock, Theo J. Moraes, Luis Rosero-Bixby, Radha S. Chari, Anne K. Ellis, Brittany M. Salter, Jenny Thiele, Danay Maestre, Caroline Duchaine, Sumaiya A. Islam, Jennifer Henri, Ingrid Baerg, Leah T. Stiemsma, Daniel E. Adams, Kate Bassil, Elinor Simons, Meaghan J. Jones, Liane J. Kang, Krzysztof Kowalik, Christopher Carlsten, Marian Hajduch, Min Hyung Ryu, Padmaja Subbarao, Hasantha Sinnock, Anita L. Kozyrskyj, Steven G. Smith, B. Brett Finlay, Jeffrey J. Fredberg, Thomas W. Boyce, Judy Morris, Per E. Gustafsson, Michelle L. North, Kyla C. Jamieson, Malcolm R. Sears, Sebastien LaVieille, Graeme Nusca, David S. Guttman, Andrea Arevalos, Bahar Torabi, Marco Sanchez-Guerra, Edmond S. Chan, Piushkumar J. Mandhane, Amrit Singh, Chen Xi Yang, Susan Balkovec, Caitlin Obminski, Tedd Konya, Roma Sehmi, Julie L. MacIssac, Bimal Chhetri, Marie-Renée Blanchet, Joseph O. Okeme, Zihang Lu, Pierre Camateros, Kelly M. McNagny, Andrea A. Baccarelli, Lawrence Joseph, Harley Eisman, Anne-Marie Lauzon, Gregory E. Miller, S. JasemineYang, Erin E. Gill, John-Paul Oliveria, Ann E. Clarke, Michael S. Kobor, Aimee Dubeau, Lisa M. McEwen, Hamid Tavakoli, Suman Dhal, Carlos Sandoval, James A. Scott, Wei Hao Dai, Hyang-Min Byun, Rupasri Mandal, Nicole R. Bush, Takeshi Morimoto, Julia L. MacIsaac, Frantisek Kopriva, Mon H. Tun, Jeremy A. Hirota, Aman Saini, David H. Rehkopf, David Marsolais, Amy S. Lee, Delbert R. Dorscheid, Christof Brückmann, Mark Larché, Suzanne Beaudin, Paul M. O'Byrne, Marta E. Chico, Rachel D. Edgar, Bruce Mazer, David S. Wishart, Catherine J. Field, Jeff Kwong, Miriam Diamond, Wendy Lou, James G. Martin, Diana L. Lefebvre, Sofianne Gabrielli, Michael Wang, Meghan B. Azad, Pascale Blais-Lecours, Louis-Philippe Boulet, Stuart E. Turvey, Paige Lacy, Petya Koleva, Jeff Xia, Scott J. Tebbutt

Publikováno v: Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18df695be6e5eef3faaeb99a51bf6e8
https://doi.org/10.1186/s13223-016-0164-7