Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Kye-Im Jeon"'
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103235- (2024)
Myofibroblasts are key cellular effectors of corneal wound healing from trauma, surgery, or infection. However, their persistent deposition of disorganized extracellular matrix can also cause corneal fibrosis and visual impairment. Recent work showed
Externí odkaz:
https://doaj.org/article/65272de4f0474663985d671b3d2ca72c
How scars shape the neural landscape: Key molecular mediators of TGF-β1's anti-neuritogenic effects.
Autor:
Kye-Im Jeon, Krystel R Huxlin
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0234950 (2020)
Following injury to the peripheral and central nervous systems, tissue levels of transforming growth factor (TGF)-β1 often increase, which is key for wound healing and scarring. However, active wound regions and scars appear to inhibit process outgr
Externí odkaz:
https://doaj.org/article/0cb8054ec4384644ace04cb6290ed95d
Publikováno v:
Investigative ophthalmologyvisual science. 63(4)
Fibrosis caused by corneal wounding can lead to scar formation, impairing vision. Although preventing fibroblast-to-myofibroblast differentiation has therapeutic potential, effective mechanisms for doing so remain elusive. Recent work shows that mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ebcc823912d1b4d273f3c975875a60
https://pubmed.ncbi.nlm.nih.gov/35377925
https://pubmed.ncbi.nlm.nih.gov/35377925
Publikováno v:
Biochem Biophys Res Commun
Corneal scarring is a major cause of blindness worldwide with few effective therapeutic options. Finding a treatment would be of tremendous public health benefit, but requires a thorough understanding of the complex interactions that underlie this ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fb2bbdbaf42bdf24539beffd452c00
https://doi.org/10.1016/j.bbrc.2019.10.107
https://doi.org/10.1016/j.bbrc.2019.10.107
Autor:
Krystel R Huxlin, Holly B Hindman, Kye-Im Jeon, Jens Bühren, Scott MacRae, Margaret DeMagistris, David Ciufo, Patricia J Sime, Richard P Phipps
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70785 (2013)
Corneal scarring remains a major cause of blindness world-wide, with limited treatment options, all of which have side-effects. Here, we tested the hypothesis that topical application of Rosiglitazone, a Thiazolidinedione and ligand of peroxisome pro
Externí odkaz:
https://doaj.org/article/e98931fba4de4b17918cdc110a2e1d04
Publikováno v:
The American Journal of Pathology. 187:1660-1669
Wound healing after corneal injury typically involves fibrosis, with transforming growth factor β1 (TGF-β1) as one of its strongest mediators. A class of small molecules-peroxisome proliferator-activated receptor γ (PPARγ) ligands-exert potent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125c196efefa2d59cf268de2d3f7fb5b
https://doi.org/10.1016/j.ajpath.2017.04.002
https://doi.org/10.1016/j.ajpath.2017.04.002
Autor:
Xuan Liu, Kye-Im Jeon, Pingjin Gao, Clint L. Miller, Soyeon Lim, Jun Ichi Abe, Chen Yan, Yu-Jun Cai, Jian Dong Li, Hirofumi Jono
Publikováno v:
FEBS Journal. 277:5026-5039
The phenotypic change of vascular smooth muscle cells (VSMCs), from a 'contractile' phenotype to a 'synthetic' phenotype, is crucial for pathogenic vascular remodeling in vascular diseases such as atherosclerosis and restenosis. Ca(2+)/calmodulin-sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0c4e50e639d0a6d046f90affbcf7837
https://doi.org/10.1111/j.1742-4658.2010.07908.x
https://doi.org/10.1111/j.1742-4658.2010.07908.x
Publikováno v:
Circulation Research. 101:811-818
Endothelial barrier dysfunction leading to increased permeability and vascular leakage is an underlying cause of several pathological conditions, including edema and sepsis. Whereas cAMP has been shown to decrease endothelial permeability, the role o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c24517b0a823a5a8d992ffca2986ce1
https://doi.org/10.1161/circresaha.107.154229
https://doi.org/10.1161/circresaha.107.154229
Autor:
Tetsuro Shishido, Seigo Itoh, Bo Ding, Weimin Liu, Haodong Xu, Kye-Im Jeon, Jun Ichi Abe, Carlos A. Molina, Burns C. Blaxall, Chen Yan, Chang Hoon Woo, Carolyn McClain
Publikováno v:
Circulation Research. 100:510-519
Substantial evidence suggests that the progressive loss of cardiomyocytes caused by apoptosis significantly contributes to the development of heart failure. beta-Adrenergic receptor activation and subsequent persistent phosphodiesterase 3A (PDE3A) do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe1cd30345bd733a4fd1e741433721a
https://doi.org/10.1161/01.res.0000259045.49371.9c
https://doi.org/10.1161/01.res.0000259045.49371.9c
Publikováno v:
Experimental eye research. 138
Ligands of Peroxisome Proliferator Activated Receptor gamma (PPARγ) possess strong anti-fibrotic properties in the cornea and several other body tissues. In the cornea, we recently showed this class of molecules to prevent stromal myofibroblast diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0096403241aa9475e611b030ed76ee
https://pubmed.ncbi.nlm.nih.gov/26142957
https://pubmed.ncbi.nlm.nih.gov/26142957