Nanonization and Deformable Behavior of Fattigated Peptide Drug in Mucoadhesive Buccal Films

Autor: Woojun Kim, Hai V. Ngo, Hy D. Nguyen, Ji-Min Park, Kye Wan Lee, Chulhun Park, Jun-Bom Park, Beom-Jin Lee

Publikováno v: Pharmaceutics, Vol 16, Iss 4, p 468 (2024)

This study was tasked with the design of mucoadhesive buccal films (MBFs) containing a peptide drug, leuprolide (LEU), or its diverse nanoparticles (NPs), for enhanced membrane permeability via self-assembled nanonization and deformable behavior. An

Externí odkaz: https://doaj.org/article/1589829d3ddc49fc8ddfd6d21014ac33

Determination of Leuprolide–Fatty Acid Conjugate in Rat Plasma Using LC-MS/MS and Its Pharmacokinetics after Subcutaneous Administration in Rats

Autor: Gi-Sang Seong, Seong-Wook Seo, Ji Young Cho, Kye Wan Lee, Beom-Jin Lee, In-Soo Yoon, Hyo-Eon Jin

Publikováno v: Molecules, Vol 27, Iss 24, p 8716 (2022)

Leuprolide is a synthetic nonapeptide drug (pyroGlu-His-Trp-Ser-Tyr-d-Leu-Leu-Arg-Pro-NHEt) that acts as a gonadotropin-releasing hormone agonist. The continuous administration of therapeutic doses of leuprolide inhibits gonadotropin secretion, which

Externí odkaz: https://doaj.org/article/438b581e866947c8a7b8401da4df5979

Physicochemical and Biopharmaceutical Controllability of New Self-Assembled Fatty Acid Conjugated Leuprolide for the Enhanced Anticancer Activity

Autor: Hai V Ngo, Hye-Eun Bak, Hy D Nguyen, Kye Wan Lee, Chulhun Park, Beom-Jin Lee

Publikováno v: International Journal of Nanomedicine.

Hai V Ngo,1 Hye-Eun Bak,1 Hy D Nguyen,1 Kye Wan Lee,2 Chulhun Park,3 Beom-Jin Lee1 1College of Pharmacy, Ajou University, Suwon, 16499 Republic of Korea; 2Dongkook Pharmaceutical Co., Ltd., Seoul, 06072 Republic of Korea; 3College of Pharmacy, Jeju N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef3546bbc4468cc593131d8228fcc47
https://www.dovepress.com/physicochemical-and-biopharmaceutical-controllability-of-new-self-asse-peer-reviewed-fulltext-article-IJN

Hydroxyl Group-Targeted Conjugate and Its Self-Assembled Nanoparticle of Peptide Drug: Effect of Degree of Saturation of Fatty Acids and Modification of Physicochemical Properties

Autor: Jisoo Park, Hai V Ngo, Hyo-Eon Jin, Kye Wan Lee, Beom-Jin Lee

Publikováno v: International Journal of Nanomedicine. 17:2243-2260

Jisoo Park,1,* Hai V Ngo,1,* Hyo-Eon Jin,1 Kye Wan Lee,2 Beom-Jin Lee1 1Bioavailability Control Laboratory, College of Pharmacy, Ajou University, Suwon, 16499, Republic of Korea; 2Dongkook Pharmaceutical Co., Ltd, Seoul, Republic of Korea&ast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb236c890e96d6c9a12ab3640103ef7b
https://doi.org/10.2147/ijn.s356804

Chemical constituents of leaves of Persea americana (avocado) and their protective effects against neomycin-induced hair cell damage

Autor: Seung Hyun Kim, Isabel Rodriguez, Do Hoon Kim, Tong Ho Kang, Kwang Won Jeong, Seon Ju Park, Kye Wan Lee, Hee Jae Kwak, Mira Oh, Se-Young Choung, In Seok Moon, Jung Suk Lee, Min Seon Park, Bin Na Hong, Yu Hwa Park, Jun Hyung Park, Youngse Oh, Youn Hee Nam

Publikováno v: Revista Brasileira de Farmacognosia, Vol 29, Iss 6, Pp 739-743 (2019)
Revista Brasileira de Farmacognosia v.29 n.6 2019
Revista Brasileira de Farmacognosia
Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA

Persea americana Mill., Lauraceae, commonly known as the avocado, is native to tropical and subtropical regions, including Brazil. From the leaves of P. americana, one previously undescribed flavonol glycoside (1) together with ten known flavonoids (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274d76ad54fe21196e109c0a7bb886f7
http://www.sciencedirect.com/science/article/pii/S0102695X19302832