Zobrazeno 1 - 10 of 81 pro vyhledávání: '"Ky-Youb Nam"'
1
Akademický článek
Investigation of Hot Spot Region in XIAP Inhibitor Binding Site by Fragment Molecular Orbital Method
Autor: Hocheol Lim, Xuemei Jin, Jongwan Kim, Sungbo Hwang, Ki Beom Shin, Jiwon Choi, Ky-Youb Nam, Kyoung Tai No
Publikováno v: Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 1217-1225 (2019)
X-linked inhibitor of apoptosis protein (XIAP) is an important regulator of cancer cell survival whose BIR3 domain (XIAP-BIR3) recognizes the Smac N-terminal tetrapeptide sequence (AVPI), making it an attractive protein-protein interaction (PPI) targ
Externí odkaz: https://doaj.org/article/8a0ad527699447c4abc973ae10dfc394
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2
Abstract 1627: PHI-501, a novel and potent pan-RAF inhibitor in metastatic melanoma
Autor: Namkyeong Kim, Jung Hee Park, Ky-Youb Nam, June H-J Han, Kyu-Tae Kim, Sandip Sengupta, Jeong Hyeok Yoon, Taebo Sim
Publikováno v: Cancer Research. 83:1627-1627
Background: PHI-501 has been developed as a novel inhibitor of NRAS mutated acute myeloid leukemia. Big data and artificial intelligence (AI)-based drug discovery platform and cell-based investigation identified PHI-501 repurposable against melanoma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::042c73ad2983f6d85826d8fe72119d93
https://doi.org/10.1158/1538-7445.am2023-1627
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3
Abstract 411: PHI-501, a novel pan-RAF/DDRs dual kinase inhibitor, overcomes BRAF or MEK inhibitor resistance in melanoma
Autor: Sue Min Kim, Jung Hee Park, Ky-Youb Nam, June H-J Han, Kyu-Tae Kim, Jeong Hyeok Yoon, Sandip Sengupta, Taebo Sim, Sang Joon Shin
Publikováno v: Cancer Research. 83:411-411
Background: PHI-501 is a newly developed, highly effective, and orally accessible dual inhibitor for pan-RAF and discoidin domain receptor (DDR) that is a collagen-activated receptor tyrosine kinase. Mutations of the BRAF and NRAS are the most common
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9878f8f217c74cd66ce0f0273bb5ba91
https://doi.org/10.1158/1538-7445.am2023-411
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5
Akademický článek
Modulation of intracellular calcium levels by calcium lactate affects colon cancer cell motility through calcium-dependent calpain.
Autor: Pasupathi Sundaramoorthy, Jae Jun Sim, Yeong-Su Jang, Siddhartha Kumar Mishra, Keun-Yeong Jeong, Poonam Mander, Oh Byung Chul, Won-Sik Shim, Seung Hyun Oh, Ky-Youb Nam, Hwan Mook Kim
Publikováno v: PLoS ONE, Vol 10, Iss 1, p e0116984 (2015)
Cancer cell motility is a key phenomenon regulating invasion and metastasis. Focal adhesion kinase (FAK) plays a major role in cellular adhesion and metastasis of various cancers. The relationship between dietary supplementation of calcium and colon
Externí odkaz: https://doaj.org/article/37ac752fe7d94355928af0be72b48f14
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6
Discovery of a Novel Triazolopyridine Derivative as a Tankyrase Inhibitor
Autor: Hwani Ryu, Joon Kim, Jiyeon Ahn, Sang-Gu Hwang, Jae-Sung Kim, Ky-Youb Nam, Jie-Young Song, Hyo Jeong Kim
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences, Vol 22, Iss 7330, p 7330 (2021)
More than 80% of colorectal cancer patients have adenomatous polyposis coli (APC) mutations, which induce abnormal WNT/β-catenin activation. Tankyrase (TNKS) mediates the release of active β-catenin, which occurs regardless of the ligand that trans
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5fa5b4bd3a9b7bf82447c04a398c9a
http://europepmc.org/articles/PMC8303674
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7
Radiosensitizing Effect of Novel Phenylpyrimidine Derivatives on Human Lung Cancer Cells via Cell Cycle Perturbation
Autor: Jong Kuk Park, Jiyeon Ahn, Sang Un Choi, Jeong-In Park, Kyung Hee Song, Ky-Youb Nam, Seung-Youn Jung, Jie-Young Song, Hong-Duck Um, Sang-Gu Hwang
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 370:514-527
Radiotherapy is one of the most common treatments for cancer, but radioresistance and injury to normal tissue are considered major obstacles to successful radiotherapy. Thus, there is an urgent need to develop radiosensitizers to improve the therapeu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93bfa1c4880b4dc6c152e7534f0ac9c5
https://doi.org/10.1124/jpet.119.257717
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8
Investigation of Hot Spot Region in XIAP Inhibitor Binding Site by Fragment Molecular Orbital Method
Autor: Ki Beom Shin, Hocheol Lim, Jongwan Kim, Ky Youb Nam, Jiwon Choi, Xuemei Jin, Kyoung Tai No, Sungbo Hwang
Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1217-1225 (2019)
X-linked inhibitor of apoptosis protein (XIAP) is an important regulator of cancer cell survival whose BIR3 domain (XIAP-BIR3) recognizes the Smac N-terminal tetrapeptide sequence (AVPI), making it an attractive protein-protein interaction (PPI) targ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846bf79946fc3f084b4f54bfe22d3220
https://doi.org/10.1016/j.csbj.2019.08.004
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9
Akademický článek
Design and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1.
Autor: Ganipisetti Srinivasrao, Jung-Eun Park, Sungmin Kim, Mija Ahn, Chaejoon Cheong, Ky-Youb Nam, Pethaiah Gunasekaran, Eunha Hwang, Nam-Hyung Kim, Song Yub Shin, Kyung S Lee, Eunkyung Ryu, Jeong Kyu Bang
Publikováno v: PLoS ONE, Vol 9, Iss 9, p e107432 (2014)
Polo-like kinase-1 (Plk1) plays a crucial role in cell proliferation and the inhibition of Plk1 has been considered as a potential target for specific inhibitory drugs in anti-cancer therapy. Several research groups have identified peptide-based inhi
Externí odkaz: https://doaj.org/article/6502c90b36834e9e8407e0cb83604792
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10
Abstract 5495: PHI-501, a potent and novel inhibitor of NRAS mutated acute myeloid leukemia
Autor: Ky-Youb Nam, Jung Hee Park, Kyung Ah Kim, Inje Shin, June H-J Han, Kyu-Tae Kim, Jeong Hyeok Yoon, Hanna Cho, Seung-Hye Choi, Sandip Sengupta, Taebo Sim
Publikováno v: Cancer Research. 82:5495-5495
Purpose: Development of the first-in-class inhibitor of NRAS mutated acute myeloid leukemia. PHI-501 has potent activity against receptor tyrosine kinases and intracellular kinases related to STAT, AKT, and ERK signaling. Description: Preclinical tes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7493949cf8b1960a8f6e2e9d7ec7e54
https://doi.org/10.1158/1538-7445.am2022-5495
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