Zobrazeno 1 - 10 of 175 pro vyhledávání: '"Kwong-Y. Tsang"'
1
Akademický článek
Generation of the therapeutic monoclonal antibody NEO-201, derived from a cancer vaccine, which targets human malignancies and immune suppressor cells
Autor: Massimo Fantini, Kwong Y. Tsang, Philip M. Arlen
Publikováno v: Expert Review of Vaccines, Vol 23, Iss 1, Pp 812-829 (2024)
Introduction Cancer vaccines stimulate the activation of specific humoral and cellular adaptive responses against cancer cells.Antibodies generated post vaccination can be isolated and further selected to develop highly specific and potent monoclonal
Externí odkaz: https://doaj.org/article/1f18e28cebf54c5d90d36e6bdae7d26f
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2
Akademický článek
First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors
Autor: Christopher B. Cole, Maria Pia Morelli, Massimo Fantini, Markku Miettinen, Patricia Fetsch, Cody Peer, William D. Figg, Tyler Yin, Nicole Houston, Ann McCoy, Stanley Lipkowitz, Alexandra Zimmer, Jung-min Lee, Miroslava Pavelova, Erin N. Villanueva, Kathryn Trewhitt, B. Brooke Solarz, Maria Fergusson, Sharon A. Mavroukakis, Anjum Zaki, Kwong Y. Tsang, Philip M. Arlen, Christina M. Annunziata
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-17 (2023)
Abstract Background NEO201 is a humanized IgG1 monoclonal antibody (mAb) generated against tumor-associated antigens from patients with colorectal cancer. NEO-201 binds to core 1 or extended core 1 O-glycans expressed by its target cells. Here, we pr
Externí odkaz: https://doaj.org/article/156401e08d7b44f9b984a38a26842574
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5
Akademický článek
Evaluation of the Anti-Tumor Activity of the Humanized Monoclonal Antibody NEO-201 in Preclinical Models of Ovarian Cancer
Autor: Kristen P. Zeligs, Maria Pia Morelli, Justin M. David, Monica Neuman, Lidia Hernandez, Stephen Hewitt, Michelle Ozaki, Akosua Osei-Tutu, David Anderson, Thorkell Andresson, Sudipto Das, Justin Lack, Abdalla Abdelmaksoud, Massimo Fantini, Philip M. Arlen, Kwong Y. Tsang, Christina M. Annunziata
Publikováno v: Frontiers in Oncology, Vol 10 (2020)
Purpose: Despite high initial response rates with cytoreductive surgery, conventional chemotherapy and the incorporation of biologic agents, ovarian cancer patients often relapse and die from their disease. New approaches are needed to improve patien
Externí odkaz: https://doaj.org/article/e7c630372871404ba4799461b16ca534
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10
Data from Immune Impact Induced by PROSTVAC (PSA-TRICOM), a Therapeutic Vaccine for Prostate Cancer
Autor: Jeffrey Schlom, Christopher R. Heery, Seth M. Steinberg, David J. Liewehr, James W. Hodge, Jo A. Tucker, Benedetto Farsaci, Jennifer L. Marté, Caroline Jochems, Kwong Y. Tsang, Ravi A. Madan, James L. Gulley
PSA-TRICOM (PROSTVAC) is a novel vector-based vaccine designed to generate a robust immune response against prostate-specific antigen (PSA)-expressing tumor cells. The purpose of this report is to present an overview of both published studies and new
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ec4c357cb6050de37eff9cd4269a9ab
https://doi.org/10.1158/2326-6066.c.6548285.v1
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