Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Kwong-Man Ng"'
Autor:
Xin-Yi Wu, Yee-Ki Lee, Yee-Man Lau, Ka-Wing Au, Yiu-Lam Tse, Kwong-Man Ng, Chun-Ka Wong, Hung-Fat Tse
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1030 (2024)
Variants (pathogenic) of the LMNA gene are a common cause of familial dilated cardiomyopathy (DCM), which is characterised by early-onset atrioventricular (AV) block, atrial fibrillation and ventricular tachyarrhythmias (VTs), and progressive heart f
Externí odkaz:
https://doaj.org/article/f0ae3e135ec24ccfb67cfad1290873a5
Autor:
Rui Wei, Jiayin Yang, Chi-Wa Cheng, Wai-In Ho, Na Li, Yang Hu, Xueyu Hong, Jian Fu, Bo Yang, Yuqing Liu, Lixiang Jiang, Wing-Hon Lai, Ka-Wing Au, Wai-Ling Tsang, Yiu-Lam Tse, Kwong-Man Ng, Miguel A. Esteban, Hung-Fat Tse
Publikováno v:
JHEP Reports, Vol 4, Iss 1, Pp 100389- (2022)
Background & Aims: Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism caused by loss-of-function mutations in ATP7B, which encodes a copper-transporting protein. It is characterized by excessive copper deposition in tissu
Externí odkaz:
https://doaj.org/article/7251fd1424cb470896b40e7153068479
Autor:
Kwong-Man Ng, Yee-Man Lau, Vidhu Dhandhania, Zhu-Jun Cai, Yee-Ki Lee, Wing-Hon Lai, Hung-Fat Tse, Chung-Wah Siu
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Empagliflozin, a sodium-glucose co-transporter (SGLT) inhibitor, reduces heart failure and sudden cardiac death but the underlying mechanisms remain elusive. In cardiomyocytes, SGLT1 and SGLT2 expression is upregulated in diabetes mellitus,
Externí odkaz:
https://doaj.org/article/645fea2d98e649728a8b8a8d073e5a30
Autor:
Jamie Morton, MBBS, PhD, Shisan Bao, MD, PhD, Laura Z. Vanags, BSc, PhD, Tania Tsatralis, BSc, Anisyah Ridiandries, BSc, PhD, Chung-Wah Siu, MBBS, MD, Kwong-Man Ng, BSc, PhD, Joanne T.M. Tan, BSc, PhD, David S. Celermajer, MBBS, PhD, Martin K.C. Ng, MBBS, PhD, Christina A. Bursill, BSc, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 187-199 (2018)
Summary: Preclinical studies have shown benefit of apolipoprotein A-I (apoA-I)/high-density lipoprotein (HDL) raising in atherosclerosis; however, this has not yet translated into a successful clinical therapy. Our studies demonstrate that apoA-I rai
Externí odkaz:
https://doaj.org/article/191bf6b8123e4c32927bf2bc5abbd323
Autor:
Cheuk-Yiu Law, Chung-Wah Siu, Katherine Fan, Wing-Hon Lai, Ka-Wing Au, Yee-Man Lau, Lai-Yung Wong, Jenny C.Y. Ho, Yee-ki Lee, Hung-Fat Tse, Kwong-Man Ng
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 335-345 (2016)
Patients with Danon disease may suffer from severe cardiomyopathy, skeletal muscle dysfunction as well as varying degrees of mental retardation, in which the primary deficiency of lysosomal membrane-associated protein-2 (LAMP2) is considerably associ
Externí odkaz:
https://doaj.org/article/4cbe27ca77554746ac132bf11ac8ccbb
Autor:
Yee‐Ki Lee, Yee‐Man Lau, Zhu‐Jun Cai, Wing‐Hon Lai, Lai‐Yung Wong, Hung‐Fat Tse, Kwong‐Man Ng, Chung‐Wah Siu
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 8 (2017)
BackgroundPrecision medicine is an emerging approach to disease treatment and prevention that takes into account individual variability in the environment, lifestyle, and genetic makeup of patients. Patient‐specific human induced pluripotent stem c
Externí odkaz:
https://doaj.org/article/2fe47303995449dd976a477d9d263a46
Autor:
Kwong-Man Ng, Yee-Ki Lee, Wing-Hon Lai, Yau-Chi Chan, Man-Lung Fung, Hung-Fat Tse, Chung-Wah Siu
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19787 (2011)
The cardioprotective effects of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A1 (apoA-I) are well documented, but their effects in the direction of the cardiac differentiation of embryonic stem cells are unknown. We evaluated the e
Externí odkaz:
https://doaj.org/article/5b66307713dd4b369004aebb8045f25a
Autor:
Janice K V Tam, Kwan-Wa Lau, Leo T O Lee, Jessica Y S Chu, Kwong-Man Ng, Alain Fournier, Hubert Vaudry, Billy K C Chow
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19384 (2011)
At present, secretin and its receptor have only been identified in mammals, and the origin of this ligand-receptor pair in early vertebrates is unclear. In addition, the elusive similarities of secretin and orexin in terms of both structures and func
Externí odkaz:
https://doaj.org/article/4db95b59f63e45b8a41c9d999e84a4ed
Autor:
Kwong-Man Ng, Qianqian Ding, Yiu-Lam Tse, Oscar Hou-In Chou, Wing-Hon Lai, Ka-Wing Au, Yee-Man Lau, Yue Ji, Chung-Wah Siu, Clara Sze-Man Tang, Alan Colman, Suk-Ying Tsang, Hung-Fat Tse
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 15609
Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by MeCP2 mutations. Nonetheless, the pathophysiological roles of MeCP2 mutations in the etiology of intrinsic cardiac abnormality and sudden death remain unclear. In this study, we pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6648a53ac225853f573886bfbd46d29e
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2429
Primary human hepatocytes (PHHs) are widely used as an in vitro model to evaluate various aspects of human hepatic physiology and pathology. However, PHHs isolated from the human liver have very limited ability for ex vivo expansion in culture. Fah
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd6a356b894a8db9f70791788ab8bcfa
https://pubmed.ncbi.nlm.nih.gov/35507175
https://pubmed.ncbi.nlm.nih.gov/35507175