PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance.

Autor: Mian Cao, Zhuo Mao, Chuen Kam, Nan Xiao, Xiaoxing Cao, Chong Shen, Kenneth K Y Cheng, Aimin Xu, Kwong-Man Lee, Liwen Jiang, Jun Xia

Publikováno v: PLoS Biology, Vol 11, Iss 4, p e1001541 (2013)

Diabetes is a metabolic disorder characterized by hyperglycemia. Insulin, which is secreted by pancreatic beta cells, is recognized as the critical regulator of blood glucose, but the molecular machinery responsible for insulin trafficking remains po

Externí odkaz: https://doaj.org/article/de5d6b16d51e44cea7dea0aaaf73e902

Vitamin D Among Children in Asia

Autor: Alec Lik-Hang Hung, Jack C. Y. Cheng, Kwong Man Lee, Benjamin Hon Kei Yip, Wayne Yuk-Wai Lee, Tsz Ping Lam, Nelson L.S. Tang, Bobby K. W. Ng

Publikováno v: Nutritional Influences on Bone Health ISBN: 9783319984636

Puberty is the prime time for bone mineral accretion to achieve peak bone mass which is key for determining bone health and preventing osteoporosis in late adulthood. In the absence of physical ailments, the importance of bone health and vitamin D (V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebce60791ad1a8c2984af7ca4be3f71f
https://doi.org/10.1007/978-3-319-98464-3_3

Abnormal Bone Mechanical and Structural Properties in Adolescent Idiopathic Scoliosis: A Study with Finite Element Analysis and Structural Model Index

Autor: Tracy Y. Zhu, Ling Qin, Fiona Wai Ping Yu, Ka-Yee Cheuk, V. W. Y. Hung, Kwong Man Lee, Tsz Ping Lam, Jack C. Y. Cheng

Publikováno v: Calcified Tissue International. 97:343-352

Previous studies found adolescent idiopathic scoliosis (AIS) is associated with low bone mineral density (BMD) and abnormal bone quality, whilst the association between AIS and their bone strength is unknown. From high-resolution peripheral quantitat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22689de0ac21836b2f51908a65f0889e
https://doi.org/10.1007/s00223-015-0025-2

Abnormal Response of the Proliferation and Differentiation of Growth Plate Chondrocytes to Melatonin in Adolescent Idiopathic Scoliosis

Autor: Yong Qiu, Hiu-Yan Yeung, Kwong-Man Lee, Bobby K. W. Ng, Tzi Bun Ng, Gene Chi Wai Man, Jack C. Y. Cheng, William Wei Jun Wang, John Wong

Publikováno v: International Journal of Molecular Sciences, Vol 15, Iss 9, Pp 17100-17114 (2014)
International Journal of Molecular Sciences; Volume 15; Issue 9; Pages: 17100-17114
International Journal of Molecular Sciences

Abnormalities in the melatonin signaling pathway and the involvement of melatonin receptor MT2 have been reported in patients with adolescent idiopathic scoliosis (AIS). Whether these abnormalities were involved in the systemic abnormal skeletal grow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8629d5366a9074212fa31e4c6ad8759
https://doi.org/10.3390/ijms150917100

Quantitative Ultrasound for Predicting Curve Progression in Adolescent Idiopathic Scoliosis: A Prospective Cohort Study of 294 Cases Followed-Up Beyond Skeletal Maturity

Autor: Kwong Man Lee, Jack C. Y. Cheng, Ling Qin, Winnie C.W. Chu, Hiu Yan Yeung, Bobby K. W. Ng, Tsz Ping Lam, Vivian Wing-Yin Hung

Publikováno v: Ultrasound in Medicine & Biology. 39:381-387

Adolescent idiopathic scoliosis (AIS) is prevalent among adolescents and can carry significant morbidities. We evaluated the use of quantitative ultrasound (QUS) for predicting curve progression in patients with AIS. We recruited 294 girls with AIS a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfbc42533108df1a3d9a34aecc0bb83
https://doi.org/10.1016/j.ultrasmedbio.2012.09.012