Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kwon-Bok Kim"'
Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers
Autor:
Julia Blievernicht, Jae-Gook Shin, Lang Li, Ulrich M. Zanger, Doo-Yeoun Cho, David A. Flockhart, Joan H.Q. Shen, Zeruesenay Desta, Todd C. Skaar, Suzanne Lemler, Kwon Bok Kim
Publikováno v:
Drug Metabolism and Pharmacokinetics. 31:107-116
The effect of rifampin on the in vivo metabolism of the antiretroviral drug efavirenz was evaluated in healthy volunteers. In a cross-over placebo control trial, healthy subjects (n = 20) were administered a single 600 mg oral dose of efavirenz after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc794d879036cc0a4b0111fc13938fe
https://doi.org/10.1016/j.dmpk.2015.07.002
https://doi.org/10.1016/j.dmpk.2015.07.002
Autor:
Young-Ran Yoon, Soo Jin Oh, Yong Ha Chi, Chang Seon Ryu, Jae-Kyung Jung, Dong-Hyun Kim, Young Jae Choi, Sang Kyum Kim, Soo Heui Paik, Kwon-Bok Kim, Ki Ho Lee, Ji-Yoon Lee
Publikováno v:
Xenobiotica. 46:40-51
1. The metabolites of fimasartan (FMS), a new angiotensin II receptor antagonist, were characterized in human liver microsomes (HLM) and human subjects. 2. We developed a method for a simultaneous quantitative and qualitative analysis using predictiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a646b7c6ee3a41a7230574aa52cec4a
https://doi.org/10.3109/00498254.2015.1047429
https://doi.org/10.3109/00498254.2015.1047429
Autor:
Nagi Abdalla, Kyung-Suk Oh, Jae-Gook Shin, Soo Kyung Bae, Kwon-Bok Kim, Dong-Hyun Kim, Kwang-Hyeon Liu, Ho-Sook Kim, Dhananjay D. Shinde, Ji-Hong Shon
Publikováno v:
Journal of Chromatography B. 911:113-121
Eicosanoids play an important role in various biological responses and can be used as biomarkers for specific diseases. Therefore, we developed a highly selective, sensitive, and robust liquid chromatography-tandem mass spectrometric method to measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a6b1013088a2676379f05ffd5011a3
https://doi.org/10.1016/j.jchromb.2012.11.004
https://doi.org/10.1016/j.jchromb.2012.11.004
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 56:771-777
A simple, accurate, and sensitive liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method has been developed for the simultaneous quantification of 10 antiepileptic drugs (AEDs; gabapentin (GBP), levetiracetam (LEV), valproic acid (VPA), l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224755a8b21a8e90c6a27c0f1d4778a2
https://doi.org/10.1016/j.jpba.2011.07.019
https://doi.org/10.1016/j.jpba.2011.07.019
Autor:
Hyun-Mi Kim, Chang Woo Yeo, Kwon Bok Kim, Soo Kyung Bae, Jae-Gook Shin, Fen Jiang, Kwang-Hyeon Liu, Zeruesenay Desta
Publikováno v:
Chromatographia. 73:263-271
We developed a rapid and sensitive method for determining efavirenz, 8-hydroxyefavirenz, and 8,14-dihydroxyefavirenz in human plasma simultaneously using liquid chromatography–tandem mass spectrometry (LC–MS–MS). Three compounds and ritonavir,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e2804150213c3e3351565f1aaa47785
https://doi.org/10.1007/s10337-010-1882-5
https://doi.org/10.1007/s10337-010-1882-5
Publikováno v:
Journal of Chromatography B. 877:1951-1956
We present a simple, rapid, and sensitive liquid chromatography (LC)–tandem mass spectrometry (MS/MS) method for the simultaneous quantification of rosiglitazone and its two major metabolites via CYP2C8/9, N-desmethyl and p-hydroxy rosiglitazone, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4cb82651375a0e702cdf7435a4f55b
https://doi.org/10.1016/j.jchromb.2009.05.001
https://doi.org/10.1016/j.jchromb.2009.05.001
Autor:
Hyunmi, Kim, Kwon-Bok, Kim, Hei-Young, Ku, Soo-Jin, Park, Soo Jin, Park, Hoon, Choi, Joon-Kwan, Moon, Byeoung-Soo, Park, Jeong-Han, Kim, Sung Su, Yea, Choong-Hwan, Lee, Hye Suk, Lee, Jae-Gook, Shin, Kwang-Hyeon, Liu
Publikováno v:
Drug Metabolism and Disposition. 36:1010-1015
Woohwangcheongsimwon is a traditional medicine for treating hypertension, arteriosclerosis, coma, and stroke in China and Korea. To assess potential interactions of herb and drug metabolism, commercially available Woohwangcheongsimwon suspensions wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a99f1276bfa28f2e04484a687f47af8
https://doi.org/10.1124/dmd.107.019612
https://doi.org/10.1124/dmd.107.019612
Autor:
Jae-Gook Shin, Kwon Bok Kim, Kyoung Ah Kim, Heon Jeong Lee, Kwang-Hyeon Liu, Jiyoung Park, Pil Whan Park
Publikováno v:
The Journal of Clinical Pharmacology. 48:66-72
The authors studied the effect of rifampin, a dual inducer of CYP3A and P-glycoprotein, on the pharmacokinetics and pharmacodynamics of risperidone in humans. Ten healthy male subjects were treated daily for 7 days with 600 mg rifampin or with placeb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a69c98038a2326869cdb33ecd99a856
https://doi.org/10.1177/0091270007309888
https://doi.org/10.1177/0091270007309888
Publikováno v:
Drug Metabolism and Pharmacokinetics. 32:S74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::582445ce15d7d1837bc711b1aa179083
https://doi.org/10.1016/j.dmpk.2016.10.293
https://doi.org/10.1016/j.dmpk.2016.10.293
Autor:
Dong-Hyun Kim, Kwon-Bok Kim, Jae-Gook Shin, Kwang-Hyeon Liu, Kyung-Ah Seo, So-Jeong Lee, Soo Kyung Bae
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 42(3)
Ilaprazole is a new proton pump inhibitor, designed for treatment of gastric ulcers, and developed by Il-Yang Pharmaceutical Co (Seoul, Korea). It is extensively metabolised to the major metabolite ilaprazole sulfone. In the present study, several in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882cc5ab8fbc2e1dc7fe94d275bc6437
https://pubmed.ncbi.nlm.nih.gov/22022918
https://pubmed.ncbi.nlm.nih.gov/22022918