Zobrazeno 1 - 10
of 1 836
pro vyhledávání: '"Kwok-Yung Yuen"'
Autor:
Chris Chun-Yiu Chan, Qian Guo, Jasper Fuk-Woo Chan, Kaiming Tang, Jian-Piao Cai, Kenn Ka-Heng Chik, Yixin Huang, Mei Dai, Bo Qin, Chon Phin Ong, Allen Wing-Ho Chu, Wan-Mui Chan, Jonathan Daniel Ip, Lei Wen, Jessica Oi-Ling Tsang, Tong-Yun Wang, Yubin Xie, Zhenzhi Qin, Jianli Cao, Zi-Wei Ye, Hin Chu, Kelvin Kai-Wang To, Xing-Yi Ge, Tao Ni, Dong-Yan Jin, Sheng Cui, Kwok-Yung Yuen, Shuofeng Yuan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 4028-4044 (2024)
There are only eight approved small molecule antiviral drugs for treating COVID-19. Among them, four are nucleotide analogues (remdesivir, JT001, molnupiravir, and azvudine), while the other four are protease inhibitors (nirmatrelvir, ensitrelvir, le
Externí odkaz:
https://doaj.org/article/e580066405f243c6820a3a4400b16bcf
Autor:
Manxue Jia, Hanjun Zhao, Nicholas C. Morano, Hong Lu, Yin-Ming Lui, Haijuan Du, Jordan E. Becker, Kwok-Yung Yuen, David D. Ho, Peter D. Kwong, Lawrence Shapiro, Kelvin Kai-Wang To, Xueling Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Avian influenza A virus H7N9 causes severe human infections with >30% fatality. Currently, there is no H7N9-specific prevention or treatment for humans. Here, from a 2013 H7N9 convalescent case in Hong Kong, we isolate four hemagglutinin (HA
Externí odkaz:
https://doaj.org/article/83d250f54cd64895b1f4e8c2f5942319
Autor:
Jonathan Daniel Ip, Wing-Ming Chu, Wan-Mui Chan, Allen Wing-Ho Chu, Rhoda Cheuk-Ying Leung, Qi Peng, Anthony Raymond Tam, Brian Pui-Chun Chan, Jian-Piao Cai, Kwok-Yung Yuen, Kin-Hang Kok, Yi Shi, Ivan Fan-Ngai Hung, Kelvin Kai-Wang To
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105371- (2024)
Externí odkaz:
https://doaj.org/article/b522914c8c5943c495355d94e058e0b6
Autor:
Jonathan Daniel Ip, Wing-Ming Chu, Wan-Mui Chan, Allen Wing-Ho Chu, Rhoda Cheuk-Ying Leung, Qi Peng, Anthony Raymond Tam, Brian Pui-Chun Chan, Jian-Piao Cai, Kwok-Yung Yuen, Kin-Hang Kok, Yi Shi, Ivan Fan-Ngai Hung, Kelvin Kai-Wang To
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105273- (2024)
Summary: Background: De novo amino acid substitutions (DNS) frequently emerge among immunocompromised patients with chronic SARS-CoV-2 infection. While previous studies have reported these DNS, their significance has not been systematically studied.
Externí odkaz:
https://doaj.org/article/89e94789ce4f4b44920ae257a080861d
Autor:
Ronghui Liang, Zi-Wei Ye, Zhenzhi Qin, Yubin Xie, Xiaomeng Yang, Haoran Sun, Qiaohui Du, Peng Luo, Kaiming Tang, Bodan Hu, Jianli Cao, Xavier Hoi-Leong Wong, Guang-Sheng Ling, Hin Chu, Jiangang Shen, Feifei Yin, Dong-Yan Jin, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Shuofeng Yuan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Host survival depends on the elimination of virus and mitigation of tissue damage. Herein, we report the modulation of D-mannose flux rewires the virus-triggered immunometabolic response cascade and reduces tissue damage. Safe and inexpensiv
Externí odkaz:
https://doaj.org/article/172ab913f5fd4fd68985cd7d66bf32cb
Autor:
Estie Hon-Kiu Shun, Jianwen Situ, James Yiu-Hung Tsoi, Shusheng Wu, Jianpiao Cai, Kelvin Hon-Yin Lo, Nicholas Foo-Siong Chew, Zhiyu Li, Rosana Wing-Shan Poon, Jade Lee-Lee Teng, Vincent Chi-Chung Cheng, Kwok-Yung Yuen, Siddharth Sridhar
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTHepatitis E virus (HEV) variants infecting humans belong to two species: Paslahepevirus balayani (bHEV) and Rocahepevirus ratti (rat hepatitis E virus; rHEV). R. ratti is a ubiquitous rodent pathogen that has recently been recognized to cause
Externí odkaz:
https://doaj.org/article/8b66066f4054427d888bfd91e591ce90
Autor:
Karthik Tiruthani, Carlos Cruz‐Teran, Jasper F. W. Chan, Alice Ma, Morgan McSweeney, Whitney Wolf, Shoufeng Yuan, Vincent K. M. Poon, Chris C. S. Chan, Lakshmi Botta, Brian Farrer, Ian Stewart, Alison Schaefer, Jasmine Edelstein, Priya Kumar, Harendra Arora, Jeff T. Hutchins, Anthony J. Hickey, Kwok‐Yung Yuen, Samuel K. Lai
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 4, Pp n/a-n/a (2024)
Abstract Soluble angiotensin‐converting enzyme 2 (ACE2) can act as a decoy molecule that neutralizes severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) by blocking spike (S) proteins on virions from binding ACE2 on host cells. Based o
Externí odkaz:
https://doaj.org/article/0194f8a6b25b4295b585d8f6aa9503ad
Autor:
Xiaojuan Zhang, Stephanie Joy-Ann Lam, Jonathan Daniel Ip, Carol Ho-Yan Fong, Allen Wing-Ho Chu, Wan-Mui Chan, Yoyo Suet-Yiu Lai, Hoi-Wah Tsoi, Brian Pui-Chun Chan, Lin-Lei Chen, Xinjie Meng, Shuofeng Yuan, Hanjun Zhao, Vincent Chi-Chung Cheng, Jacqueline Kwan Yuk Yuen, Kwok-Yung Yuen, Jie Zhou, Kelvin Kai-Wang To
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109706- (2024)
Summary: SARS-CoV-2 Omicron variant has evolved into sublineages. Here, we compared the neutralization susceptibility and viral fitness of EG.5.1 and XBB.1.9.1. Serum neutralization antibody titer against EG.5.1 was 1.71-fold lower than that for XBB.
Externí odkaz:
https://doaj.org/article/408891a80f1f40e78aaa030c09782216
An interferon-integrated mucosal vaccine provides pan-sarbecovirus protection in small animal models
Autor:
Chun-Kit Yuen, Wan-Man Wong, Long-Fung Mak, Joy-Yan Lam, Lok-Yi Cheung, Derek Tsz-Yin Cheung, Yau-Yee Ng, Andrew Chak-Yiu Lee, Nanshan Zhong, Kwok-Yung Yuen, Kin-Hang Kok
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract A pan-sarbecovirus or pan-betacoronavirus vaccine that can prevent current and potential future beta-coronavirus infections is important for fighting possible future pandemics. Here, we report a mucosal vaccine that cross-protects small anim
Externí odkaz:
https://doaj.org/article/7be46c5f05934f0bb145e230a3413bda
Autor:
Juan Liu, Fengfeng Mao, Jianhe Chen, Shuaiyao Lu, Yonghe Qi, Yinyan Sun, Linqiang Fang, Man Lung Yeung, Chunmei Liu, Guimei Yu, Guangyu Li, Ximing Liu, Yuansheng Yao, Panpan Huang, Dongxia Hao, Zibing Liu, Yu Ding, Haimo Liu, Fang Yang, Pan Chen, Rigai Sa, Yao Sheng, Xinxin Tian, Ran Peng, Xue Li, Junmian Luo, Yurui Cheng, Yule Zheng, Yongqing Lin, Rui Song, Ronghua Jin, Baoying Huang, Hyeryun Choe, Michael Farzan, Kwok-Yung Yuen, Wenjie Tan, Xiaozhong Peng, Jianhua Sui, Wenhui Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Many of the currently available COVID-19 vaccines and therapeutics are not effective against newly emerged SARS-CoV-2 variants. Here, we developed the metallo-enzyme domain of angiotensin converting enzyme 2 (ACE2)—the cellular receptor of
Externí odkaz:
https://doaj.org/article/8b118b6b063b457f8f4c4940e76438c7