Zobrazeno 1 - 10
of 553
pro vyhledávání: '"Kwok-On Lai"'
Autor:
Albert Hiu Ka Fok, Yuhua Huang, Beth Wing Lam So, Qiyu Zheng, Chun Sing Carlos Tse, Xiaoyang Li, Kenneth Kin-Yip Wong, Jiandong Huang, Kwok-On Lai, Cora Sau Wan Lai
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113906- (2024)
Summary: Kinesin 1 (KIF5) is one major type of motor protein in neurons, but its members’ function in the intact brain remains less studied. Using in vivo two-photon imaging, we find that conditional knockout of Kif5b (KIF5B cKO) in CaMKIIα-Cre-ex
Externí odkaz:
https://doaj.org/article/74aa4e2ce3e544d9814de6b1a079c9d3
Autor:
Louisa Hoi-Ying Lo, Kwok-On Lai
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-9 (2020)
Abstract Autism spectrum disorder (ASD) is a brain disorder that involves changes in neuronal connections. Abnormal morphology of dendritic spines on postsynaptic neurons has been observed in ASD patients and transgenic mice that model different mono
Externí odkaz:
https://doaj.org/article/b2860490fb674934a2c52594cb0390d6
Autor:
Lianfeng Lin, Quanwei Lyu, Pui-Yi Kwan, Junjun Zhao, Ruolin Fan, Anping Chai, Cora Sau Wan Lai, Ying-Shing Chan, Xuting Shen, Kwok-On Lai
Publikováno v:
PLoS Genetics, Vol 16, Iss 1, p e1008587 (2020)
Perturbation of synapse development underlies many inherited neurodevelopmental disorders including intellectual disability (ID). Diverse mutations on the human TBC1D24 gene are strongly associated with epilepsy and ID. However, the physiological fun
Externí odkaz:
https://doaj.org/article/490b041e33c249168770dfdd26320f44
Autor:
Junjun Zhao, Albert Hiu Ka Fok, Ruolin Fan, Pui-Yi Kwan, Hei-Lok Chan, Louisa Hoi-Ying Lo, Ying-Shing Chan, Wing-Ho Yung, Jiandong Huang, Cora Sau Wan Lai, Kwok-On Lai
Publikováno v:
eLife, Vol 9 (2020)
The kinesin I family of motor proteins are crucial for axonal transport, but their roles in dendritic transport and postsynaptic function are not well-defined. Gene duplication and subsequent diversification give rise to three homologous kinesin I pr
Externí odkaz:
https://doaj.org/article/246138c14e2f4a2fb4cdfb1f45145d4f
Publikováno v:
Life, Vol 11, Iss 11, p 1132 (2021)
Among the nine mammalian protein arginine methyltransferases (PRMTs), PRMT8 is unusual because it has restricted expression in the nervous system and is the only membrane-bound PRMT. Emerging studies have demonstrated that this enzyme plays multiface
Externí odkaz:
https://doaj.org/article/d698f958ba154a6cadb35054e532f620
Autor:
Zhuoyi Liang, Yi Zhan, Yang Shen, Catherine C. L. Wong, John R. Yates, Florian Plattner, Kwok-On Lai, Nancy Y. Ip
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
CaMKv is a pseduokinase of unknown function. Here, the authors identify the protein as a substrate of the protein kinase Cdk5, and show that CaMKv is synthesized in response to neural activity and plays an important role in maintaining dendritic spin
Externí odkaz:
https://doaj.org/article/d0ffb0de24424d838846584b6e6c4411
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Externí odkaz:
https://doaj.org/article/33063f455b9f4fd9af0884fdbb2453db
Publikováno v:
Interactive Learning Environments; Oct2024, Vol. 32 Issue 8, p4020-4036, 17p
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.