Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Kwok-K Wong"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 5, Pp 687-695 (2024)
Cancer-associated fibroblasts (CAFs), a heterogenous population, can promote cancer cell proliferation, migration, invasion, immunosuppression, and therapeutic resistance in solid tumors. These effects are mediated through secretion of cytokines and
Externí odkaz:
https://doaj.org/article/d688ca4b1e51409ca99effbc12d1f412
Autor:
Masayuki Hagiwara, Atsushi Fushimi, Atrayee Bhattacharya, Nami Yamashita, Yoshihiro Morimoto, Mototsugu Oya, Henry G. Withers, Qiang Hu, Tao Liu, Song Liu, Kwok K. Wong, Mark D. Long, Donald Kufe
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The oncogenic MUC1-C protein drives dedifferentiation of castrate resistant prostate cancer (CRPC) cells in association with chromatin remodeling. The present work demonstrates that MUC1-C is necessary for expression of IFNGR1 and activation of the t
Externí odkaz:
https://doaj.org/article/58d9e5a3b3794680b4c80efe7d984796
Autor:
Yota Yasumizu, Hasan Rajabi, Caining Jin, Tsuyoshi Hata, Sean Pitroda, Mark D. Long, Masayuki Hagiwara, Wei Li, Qiang Hu, Song Liu, Nami Yamashita, Atsushi Fushimi, Ling Kui, Mehmet Samur, Masaaki Yamamoto, Yan Zhang, Ning Zhang, Deli Hong, Takahiro Maeda, Takeo Kosaka, Kwok K. Wong, Mototsugu Oya, Donald Kufe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
MUC1-C is overexpressed in castration-resistant prostate cancer and neuroendocrine prostate cancer. Here, the authors show that MUC1-C drives lineage plasticity through MYC and BRN2, inducing neuroendocrine features and stemness in prostate cancer.
Externí odkaz:
https://doaj.org/article/122d971bc14145f181528834a1ae353b
Autor:
David A. Barbie, Marina Pasca Di Magliano, Alec C. Kimmelman, Hideo Baba, Kwok K. Wong, Shuji Ogino, Zhirong Qian, Jacob Reibel, Tran Thai, Zehua Zhu, Adam Castoreno, Eiji Oki, Arthur Brannon, Amir Aref, Shunsuke Kitajima, Israel Cañadas, Russell W. Jenkins, Yu Imamura, Shenghong Yang
Supplementary Figure 1. Characterization of inflammatory cell infiltrates and their recovery with time. Supplementary Figure 2. Negative feedback control of pTBK1 by autophagy. Supplementary Figure 3. pTBK1 levels correlate with underlying levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a8f2b3cbf123eaa35b8d7d90e1fb5b
https://doi.org/10.1158/2326-6066.22537418
https://doi.org/10.1158/2326-6066.22537418
Autor:
David A. Barbie, Marina Pasca Di Magliano, Alec C. Kimmelman, Hideo Baba, Kwok K. Wong, Shuji Ogino, Zhirong Qian, Jacob Reibel, Tran Thai, Zehua Zhu, Adam Castoreno, Eiji Oki, Arthur Brannon, Amir Aref, Shunsuke Kitajima, Israel Cañadas, Russell W. Jenkins, Yu Imamura, Shenghong Yang
Autophagy promotes tumor progression downstream of oncogenic KRAS, yet also restrains inflammation and dysplasia through mechanisms that remain incompletely characterized. Understanding the basis of this paradox has important implications for the opt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::125178c448797d45e41158c9e6cb2860
https://doi.org/10.1158/2326-6066.c.6548438.v1
https://doi.org/10.1158/2326-6066.c.6548438.v1
Autor:
Yota Yasumizu, Hasan Rajabi, Caining Jin, Tsuyoshi Hata, Sean Pitroda, Mark D. Long, Masayuki Hagiwara, Wei Li, Qiang Hu, Song Liu, Nami Yamashita, Atsushi Fushimi, Ling Kui, Mehmet Samur, Masaaki Yamamoto, Yan Zhang, Ning Zhang, Deli Hong, Takahiro Maeda, Takeo Kosaka, Kwok K. Wong, Mototsugu Oya, Donald Kufe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/0c19cb2388fb444b9ecaa6c84f5deeb4
Autor:
Eric W Lin, Tatiana A Karakasheva, Dong-Jin Lee, Ju-Seog Lee, Qi Long, Adam J Bass, Kwok K Wong, Anil K Rustgi
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006938 (2017)
Advances in genomics in recent years have provided key insights into defining cancer subtypes "within-a-tissue"-that is, respecting traditional anatomically driven divisions of medicine. However, there remains a dearth of data regarding molecular pro
Externí odkaz:
https://doaj.org/article/f5a49abecdad47b5bc1da17845d3dc18
Autor:
Lindsay A. Caprio, Christy Hong, Amit Dipak Amin, Somnath Tagore, Johannes Melms, Luke Cai, Yiping Wang, Patricia Ho, Michael Mu, Hanina Hibshoosh, Brian Henick, Kwok K. Wong, Samuel F. Bakhoum, Benjamin Izar
Publikováno v:
Cancer Research. 83:5944-5944
Non-small cell lung cancers (NSCLCs) harboring deletions or inactivating mutations in STK11 (encoding LKB1) are associated with treatment-resistance, including to immune checkpoint blockade, and poor survival, yet the underlying mechanisms are poorly
Autor:
Wei Li, Mehmet Kemal Samur, Masaaki Yamamoto, Ning Zhang, Song Liu, Nami Yamashita, Takahiro Maeda, Qiang Hu, Yota Yasumizu, Atsushi Fushimi, Sean P. Pitroda, Deli Hong, Ling Kui, Yan Zhang, Caining Jin, Kwok K. Wong, Tsuyoshi Hata, Donald Kufe, Hasan Rajabi, Mototsugu Oya, Mark D. Long, Masayuki Hagiwara, Takeo Kosaka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant prostate cancer (CRPC) and NEPC, but its specific role is unknown. Here, we
Autor:
Joshua M. Francis, Stuart L. Schreiber, Mathias Wawer, Patricia Cogswell, Francisca Vazquez, Nathanael S. Gray, James E. Bradner, Joanne Kotz, Ting Chen, Julian Blagg, Slim Sassi, Glenn S. Cowley, Matthew A. Lawlor, Tanaz Sharifnia, Paul A. Clemons, David E. Root, Paul A. Clarke, Ann E. Sizemore, William C. Hahn, Charles Y. Lin, Josh Sommer, Paul Workman, Amy Goodale, Francis J. Hornicek, Qingyuan Huang, Kwok K. Wong, Barbara A. Weir, Hadley E. Sheppard, Tinghu Zhang, Christopher J. Ott
Publikováno v:
Nature medicine
Chordoma is a primary bone cancer with no approved therapy1. The identification of therapeutic targets in this disease has been challenging due to the infrequent occurrence of clinically actionable somatic mutations in chordoma tumors2,3. Here we des