Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Kwok-Fai LAU"'
Autor:
Ashok Iyaswamy, Abhimanyu Thakur, Xin-Jie Guan, Senthilkumar Krishnamoorthi, Tsz Yan Fung, Kejia Lu, Isha Gaurav, Zhijun Yang, Cheng-Fu Su, Kwok-Fai Lau, Kui Zhang, Roy Chun-Laam Ng, Qizhou Lian, King-Ho Cheung, Keqiang Ye, Huanhuan Joyce Chen, Min Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques, hyperphosphorylated tau protein, and neurofibrillary tangles in the br
Externí odkaz:
https://doaj.org/article/6b764bb85ea2452a913aa80974bdc655
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 9, Pp 1883-1884 (2024)
Externí odkaz:
https://doaj.org/article/5a72c3fabe394723814971a14dfe6bc6
Publikováno v:
Open Biology, Vol 12, Iss 9 (2022)
ADP-ribosylation factor 6 (ARF6) is a small GTPase that has a variety of neuronal functions including stimulating neurite outgrowth, a crucial process for the establishment and maintenance of neural connectivity. As impaired and atrophic neurites are
Externí odkaz:
https://doaj.org/article/fea1850cdd1a4b9d8a32081ee7b2b077
Autor:
Qian Zhang, Ying An, Zhefan Stephen Chen, Alex Chun Koon, Kwok-Fai Lau, Jacky Chi Ki Ngo, Ho Yin Edwin Chan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 172-185 (2019)
One drug, two diseases is a rare and economical therapeutic strategy that is highly desirable in the pharmaceutical industry. We previously reported a 21-amino acid peptide named beta-structured inhibitor for neurodegenerative diseases (BIND) that ca
Externí odkaz:
https://doaj.org/article/93a3c017448d49dfb54ad5fc338c760b
Autor:
Julia Y.S. Tsang, Michelle A. Lee, Tsz-Hei Chan, Joshua Li, Yun-Bi Ni, Yan Shao, Siu-Ki Chan, Sai-Yin Cheungc, Kwok-Fai Lau, Gary M.K. Tse
Publikováno v:
EBioMedicine, Vol 38, Iss , Pp 89-99 (2018)
Background: Amyloid precursor protein (APP), best known for its association with Alzheimer disease, has recently been implicated in breast cancer progression. However, the precise mechanism involved remains unclear. Here, we investigated the role of
Externí odkaz:
https://doaj.org/article/2c965253f6ab44aabc402fa3f01e1d0b
Autor:
Chris W. Lee, Jeannette N. Stankowski, Jeannie Chew, Casey N. Cook, Ying-Wai Lam, Sandra Almeida, Yari Carlomagno, Kwok-Fai Lau, Mercedes Prudencio, Fen-Biao Gao, Matthew Bogyo, Dennis W. Dickson, Leonard Petrucelli
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-9 (2017)
Abstract Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal lobar degeneration (FTLD), the second most common cause of early-onset dementia. Receptor-mediated lysosomal targeting has been shown to regulate brain PG
Externí odkaz:
https://doaj.org/article/5c43b4a31fdf4d9685d4506f92648711
Autor:
Dennis Dik-Long Chau, Kwok-Fai Lau
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 8, Pp 1475-1476 (2020)
Externí odkaz:
https://doaj.org/article/936b745d07814a3a94bae89a606b665c
Publikováno v:
Bio-Protocol, Vol 9, Iss 23 (2019)
Intramolecular interaction is a common mechanism that regulates protein activities. Conventionally, such interactions are investigated by classical in vitro biochemical assays. Here, we describe a protocol for studying the intramolecular interaction
Externí odkaz:
https://doaj.org/article/c2b2dafeb8ec4e78a5b6093a9c6360a0
Autor:
Qian Zhang, Ho Tsoi, Shaohong Peng, Pan P. Li, Kwok-Fai Lau, Dobrila D. Rudnicki, Jacky Chi-Ki Ngo, Ho Yin Edwin Chan
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 3, Pp 321-334 (2016)
Polyglutamine (polyQ) diseases represent a group of progressive neurodegenerative disorders that are caused by abnormal expansion of CAG triplet nucleotides in disease genes. Recent evidence indicates that not only mutant polyQ proteins, but also the
Externí odkaz:
https://doaj.org/article/2c9810f11c6f4bf2b4437298fa3f9600
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 12, Pp 2085-2086 (2018)
Externí odkaz:
https://doaj.org/article/8691a80cc9884e6e84ced6500fee2ee5