Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kwok Yiu Ho"'
Autor:
Yvonne J. Rosenberg, Kelly Garcia, Justin Diener, Dennis Sullivan, Scott Donahue, Lingjun Mao, Jonathan Lees, Xiaoming Jiang, Lori A. Urban, Jeremiah D. Momper, Kwok‐Yiu Ho, Palmer Taylor
Publikováno v:
Journal of Neurochemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e666e4eaaf45abf9ba1c60d13b7b6f7a
https://doi.org/10.1111/jnc.15777
https://doi.org/10.1111/jnc.15777
Autor:
Palmer Taylor, Andrey Kovalevsky, Donald K. Blumenthal, Zoran Radić, Mikolai Fajer, Puneet Juneja, Kwok-Yiu Ho, Jacqueline Rohrer, Oksana Gerlits, Xiaolin Cheng
Publikováno v:
The Journal of biological chemistry, vol 297, iss 3
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Acetylcholinesterase (EC 3.1.1.7), a key acetylcholine-hydrolyzing enzyme in cholinergic neurotransmission, is present in a variety of states in situ, including monomers, C-terminally disulfide-linked homodimers, homotetramers, and up to three tetram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03351602374b055c8336577d63112ba
https://escholarship.org/uc/item/46z0j5wg
https://escholarship.org/uc/item/46z0j5wg
Autor:
K. Barry Sharpless, Zoran Radić, William Fenical, Gisela Andrea Camacho-Hernandez, Yan Jye Shyong, Palmer Taylor, Zrinka Kovarik, Nathan M. Samskey, Kwok Yiu Ho
We detail here distinctive departures from lead classical cholinesterase re-activators, the pyridinium aldoximes, to achieve rapid CNS penetration and reactivation of AChE in the CNS (brain and spinal cord). Such reactivation is consistent with these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ef383abc5abeea87394290920645f8
https://www.bib.irb.hr/1196012
https://www.bib.irb.hr/1196012
Autor:
Xiaolin Cheng, Kwok-Yiu Ho, Palmer Taylor, Zoran Radić, Andrey Kovalevsky, Donald K. Blumenthal, Oksana Gerlits
Publikováno v:
Chem Biol Interact
Structure-guided design of novel pharmacologically active molecules relies at least in part on functionally relevant accuracy of macromolecular structures for template based drug design. Currently, about 95% of all macromolecular X-ray structures ava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d5fb162d37962d7dabee1ef4e3a664
https://escholarship.org/uc/item/23g548gm
https://escholarship.org/uc/item/23g548gm
Autor:
Zoran Radić, K. Barry Sharpless, Nathan Samskey, Palmer Taylor, Rakesh K. Sit, Kwok-Yiu Ho, Jeremiah D. Momper
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::953a995857a784336b824172d318ee40
https://doi.org/10.1096/fasebj.2020.34.s1.06319
https://doi.org/10.1096/fasebj.2020.34.s1.06319
Autor:
Anaamika Campeau, Palmer Taylor, Michal Harel, Banumathi Sankaran, William Fenical, David Gonzalez, Franziska Schnarkowski, Kwok-Yiu Ho, Gisela Andrea Camacho Hernandez
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f9ce76e395f682e16ed7e539fc6be4e
https://doi.org/10.1096/fasebj.2020.34.s1.05138
https://doi.org/10.1096/fasebj.2020.34.s1.05138
Autor:
Mikolai Fajer, Kwok-Yiu Ho, Oksana Gerlits, Andrey Kovalevsky, Donald K. Blumenthal, Palmer Taylor, Wanlu Yu, Zoran Radić, Xiaolin Cheng
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c446fb8b5e8d2c128422df8e9e738ad
https://doi.org/10.1096/fasebj.2018.32.1_supplement.526.40
https://doi.org/10.1096/fasebj.2018.32.1_supplement.526.40
Autor:
Kwok-Yiu Ho, K. Barry Sharpless, Neil P. Grimster, Mikael Dufouil, Todd T. Talley, Kimberly Gomez, Palmer Taylor, Valery V. Fokin, John G. Yamauchi, Akos Nemecz, Joseph R. Fotsing
Publikováno v:
Molecular Pharmacology. 82:687-699
The acetylcholine-binding proteins (AChBPs), which serve as structural surrogates for the extracellular domain of nicotinic acetylcholine receptors (nAChRs), were used as reaction templates for in situ click-chemistry reactions to generate a congener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d046e32717174debae934038c192e2e7
https://doi.org/10.1124/mol.112.080291
https://doi.org/10.1124/mol.112.080291
Autor:
K. Barry Sharpless, Kwok-Yiu Ho, Neil P. Grimster, John G. Yamauchi, Akos Nemecz, Timo Weide, Choel Kim, Bernhard Stump, Palmer Taylor, Joseph R. Fotsing, Valery V. Fokin, Todd T. Talley
Publikováno v:
Journal of the American Chemical Society. 134:6732-6740
Nicotinic acetylcholine receptors (nAChRs), which are responsible for mediating key physiological functions, are ubiquitous in the central and peripheral nervous systems. As members of the Cys loop ligand-gated ion channel family, neuronal nAChRs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62476b7929cbf760f8ee0dc8f4901291
https://doi.org/10.1021/ja3001858
https://doi.org/10.1021/ja3001858
Autor:
Gabriel Amitai, K. Barry Sharpless, Tuba Tüylü Küçükkılınç, Palmer Taylor, Valery V. Fokin, Jaroslaw Kalisiak, Edzna Garcia, Zoran Radić, Zrinka Kovarik, Rory L. Cochran, Kwok-Yiu Ho, Limin Zhang
Publikováno v:
Journal of Biological Chemistry. 286:29718-29724
The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Exposure to OPs can lead to serious cardiovascular complications, respiratory compromise, and death. Current therapy to combat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f680367ff777aeb0e5efc4d47777c8e8
https://doi.org/10.1074/jbc.m111.264739
https://doi.org/10.1074/jbc.m111.264739