Zobrazeno 1 - 10
of 351
pro vyhledávání: '"Kwok Wai, Lo"'
Autor:
Man Wu, Pok Man Hau, Linxian Li, Chi Man Tsang, Yike Yang, Aziz Taghbalout, Grace Tin-Yun Chung, Shin Yee Hui, Wing Chung Tang, Nathaniel Jillette, Jacqueline Jufen Zhu, Horace Hok Yeung Lee, Ee Ling Kong, Melissa Sue Ann Chan, Jason Ying Kuen Chan, Brigette Buig Yue Ma, Mei-Ru Chen, Charles Lee, Ka Fai To, Albert Wu Cheng, Kwok-Wai Lo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The unique virus-cell interaction in Epstein-Barr virus (EBV)-associated malignancies implies targeting the viral latent-lytic switch is a promising therapeutic strategy. However, the lack of specific and efficient therapeutic agents to indu
Externí odkaz:
https://doaj.org/article/5ea7e874509d4bf389c2b2f00f71f2fc
Autor:
Bonan Chen, Peiyao Yu, Wai Nok Chan, Fuda Xie, Yigan Zhang, Li Liang, Kam Tong Leung, Kwok Wai Lo, Jun Yu, Gary M. K. Tse, Wei Kang, Ka Fai To
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-41 (2024)
Abstract Zinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular homeostasis, often coinciding with disease progression. As an essential factor in maintaining cellul
Externí odkaz:
https://doaj.org/article/09e92dfd5d834ba09b5bb3234a545c80
Autor:
Alvin Ho-Kwan Cheung, Kit-Yee Wong, Xiaoli Liu, Fenfen Ji, Chris Ho-Lam Hui, Yihan Zhang, Johnny Sheung-Him Kwan, Bonan Chen, Yujuan Dong, Raymond Wai-Ming Lung, Jun Yu, Kwok Wai Lo, Chi Chun Wong, Wei Kang, Ka-Fai To
Publikováno v:
Oncogenesis, Vol 12, Iss 1, Pp 1-14 (2023)
Abstract MLK4, a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, has been implicated in cancer progression. However, its role in lung adenocarcinoma has not been characterized. Here, we showed that MLK4 was overexpressed
Externí odkaz:
https://doaj.org/article/1fab759148bb485a803a9fe5b39656cf
Autor:
Bonan Chen, Wai Nok Chan, Fuda Xie, Chun Wai Mui, Xiaoli Liu, Alvin H. K. Cheung, Raymond W. M. Lung, Chit Chow, Zhenhua Zhang, Canbin Fang, Peiyao Yu, Shihua Shi, Shikun Zhou, Guoming Chen, Zhangding Wang, Shouyu Wang, Xiaofan Ding, Bing Huang, Li Liang, Yujuan Dong, Chi Chun Wong, William K. K. Wu, Alfred S. L. Cheng, Nathalie Wong, Jun Yu, Kwok Wai Lo, Gary M. K. Tse, Wei Kang, Ka Fai To
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 12, Pp n/a-n/a (2023)
Abstract Background Cancer‐associated fibroblasts (CAFs), integral to the tumour microenvironment, are pivotal in cancer progression, exhibiting either pro‐tumourigenic or anti‐tumourigenic functions. Their inherent phenotypic and functional di
Externí odkaz:
https://doaj.org/article/9cd923a1d35b477fa1d0c64190bf7e15
Autor:
Bonan Chen, Xiaoli Liu, Peiyao Yu, Fuda Xie, Johnny S. H. Kwan, Wai Nok Chan, Canbin Fang, Jinglin Zhang, Alvin H. K. Cheung, Chit Chow, Gloria W. M. Leung, Kam Tong Leung, Shihua Shi, Bin Zhang, Shouyu Wang, Dazhi Xu, Kaili Fu, Chi Chun Wong, William K. K. Wu, Michael W. Y. Chan, Patrick M. K. Tang, Chi Man Tsang, Kwok Wai Lo, Gary M. K. Tse, Jun Yu, Ka Fai To, Wei Kang
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 11, Pp n/a-n/a (2023)
Abstract Background Gastric cancer (GC) is one of the most common tumours in East Asia countries and is associated with Helicobacter pylori infection. H. pylori utilizes virulence factors, CagA and VacA, to up‐regulate pro‐inflammatory cytokines
Externí odkaz:
https://doaj.org/article/7bfa61a822b64b09a39959da5d928f18
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background After an infection, human cells may contain viral genomes in the form of episomes or integrated DNA. Comparing the genomic sequences of different strains of a virus in human cells can often provide useful insights into its behavio
Externí odkaz:
https://doaj.org/article/7c7b69967c834452b236e898acf83584
Publikováno v:
Discover Oncology, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract One of the many strategies that cancer cells evade death is through up-regulation of the BCL-2 anti-apoptotic proteins. Hence, these proteins have become attractive therapeutic targets. Given that different cell populations rely on different
Externí odkaz:
https://doaj.org/article/b2f20220e8744868b1bf3cfcff961dce
Autor:
Bonan Chen, Wai Nok Chan, Chun Wai Mui, Xiaoli Liu, Jinglin Zhang, Yifei Wang, Alvin H. K. Cheung, Aden K. Y. Chan, Ronald C. K. Chan, Kam Tong Leung, Yujuan Dong, Yi Pan, Huixing Ke, Li Liang, Zhaocai Zhou, Chi Chun Wong, William K. K. Wu, Alfred S. L. Cheng, Jun Yu, Kwok Wai Lo, Ka Fai To, Wei Kang
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-8 (2021)
Externí odkaz:
https://doaj.org/article/da5f5f43c8e6408e81fc62d46d3eff1a
Autor:
Ke-En Tan, Wei Lun Ng, Georgi K. Marinov, Ken Hung-On Yu, Lu Ping Tan, Ee Shan Liau, Sook Yan Goh, Kok Siong Yeo, Kevin Y. Yip, Kwok-Wai Lo, Alan Soo-Beng Khoo, Lee-Fah Yap, Chee-Kwee Ea, Yat-Yuen Lim
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Epstein-Barr virus (EBV) has been recently found to generate novel circular RNAs (circRNAs) through backsplicing. However, comprehensive catalogs of EBV circRNAs in other cell lines and their functional characterization are still lacking. In
Externí odkaz:
https://doaj.org/article/6f280b89ec074aafa9b102c63d7b3441
Autor:
Jeff P. Bruce, Ka-Fai To, Vivian W. Y. Lui, Grace T. Y. Chung, Yuk-Yu Chan, Chi Man Tsang, Kevin Y. Yip, Brigette B. Y. Ma, John K. S. Woo, Edwin P. Hui, Michael K. F. Mak, Sau-Dan Lee, Chit Chow, Sharmila Velapasamy, Yvonne Y. Y. Or, Pui Kei Siu, Samah El Ghamrasni, Stephenie Prokopec, Man Wu, Johnny S. H. Kwan, Yuchen Liu, Jason Y. K. Chan, C. Andrew van Hasselt, Lawrence S. Young, Christopher W. Dawson, Ian C. Paterson, Lee-Fah Yap, Sai-Wah Tsao, Fei-Fei Liu, Anthony T. C. Chan, Trevor J. Pugh, Kwok-Wai Lo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The genomic characterisation of nasopharyngeal carcinoma (NPC) remains crucial. Here, the authors perform whole-genome sequencing for 70 NPCs with EBV gene expression, report the somatic alterations and EBV-mediated effects converging on NF-κB activ
Externí odkaz:
https://doaj.org/article/84b65b92c11446b886dec64811b68199