Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kwok Ho Christopher Choy"'
Autor:
Maren Klug, Rachel A. Hill, Kwok Ho Christopher Choy, Michael Kyrios, Anthony J. Hannan, Maarten van den Buuse
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 3, Pp 722-731 (2012)
Psychiatric illnesses, such as schizophrenia, are most likely caused by an interaction between genetic predisposition and environmental factors, including stress during development. The neurotrophin, brain-derived neurotrophic factor (BDNF) has been
Externí odkaz:
https://doaj.org/article/72f3510efa534035a9ea7895497d0dcc
Autor:
Liang Jin, Ilenia Di Stefano, Joseph A. Nicolazzo, Sanjeevini Babu Reddiar, Raymond S. Norton, Yi Ling Low, Dorothy C.C. Wai, Kwok Ho Christopher Choy, Yijun Pan
Publikováno v:
Journal of Pharmaceutical Sciences. 111:638-647
The expression of voltage-gated potassium Kv1.3 channels is increased in activated microglia, with non-selective blockade reported to attenuate microglial-mediated neuroinflammation. In this study, we evaluated the impact of a potent and selective pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ce4098e38f03d89e718df30bd2c0c2
https://doi.org/10.1016/j.xphs.2021.11.003
https://doi.org/10.1016/j.xphs.2021.11.003
Autor:
Celine Valant, Peter J. Scammells, Arthur Christopoulos, Ben Capuano, Manuela Jörg, Patrick M. Sexton, Elham Khajehali, David M. Shackleford, Kwok Ho Christopher Choy, Andrew B. Tobin, Emma T van der Westhuizen
Publikováno v:
ChemMedChem. 16:216-233
This study investigated the structure-activity relationships of 4-phenylpyridin-2-one and 6-phenylpyrimidin-4-one M1 muscarinic acetylcholine receptor (M1 mAChRs) positive allosteric modulators (PAMs). The presented series focuses on modifications to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c2a8709f5b47591f003a0e2e8c6a516
https://doi.org/10.1002/cmdc.202000540
https://doi.org/10.1002/cmdc.202000540
Autor:
Christopher Yap, Durgesh Tiwari, Joseph A. Nicolazzo, Kwok Ho Christopher Choy, Jennifer L. Short, Danielle Senyschyn, Stephanie A. Newman, Yijun Pan, William A. Banks
Publikováno v:
Brain, behavior, and immunity. 70
Epidemiological evidence suggests that people with bipolar disorder prescribed lithium exhibit a lower risk of Alzheimer’s disease (AD) relative to those prescribed other mood-stabilizing medicines. Lithium chloride (LiCl) reduces brain β-amyloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6ac9127c3cf9d94cb48187a37237af
https://pubmed.ncbi.nlm.nih.gov/29545118
https://pubmed.ncbi.nlm.nih.gov/29545118
Autor:
Philip J. Marriott, Joseph A. Nicolazzo, Martin J. Scanlon, Jennifer L. Short, Yijun Pan, Christopher J.H. Porter, Kwok Ho Christopher Choy, Siew Yeen Chai
Publikováno v:
Journal of neurochemistry. 144(1)
Lower levels of the cognitively-beneficial docosahexaenoic acid (DHA) are often observed in Alzheimer's disease (AD) brains. Brain DHA levels are regulated by the blood-brain barrier (BBB) transport of plasma-derived DHA, a process facilitated by fat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b85221b8d90da6554fb645cad257693
https://pubmed.ncbi.nlm.nih.gov/29105065
https://pubmed.ncbi.nlm.nih.gov/29105065
Autor:
Patrick M. Sexton, Nevin A. Lambert, Kwok Ho Christopher Choy, Meritxell Canals, Arthur Christopoulos, Holly R. Yeatman, J. Robert Lane
Publikováno v:
Journal of Biological Chemistry. 289:15856-15866
Allosteric modulators are an attractive approach to achieve receptor subtype-selective targeting of G protein-coupled receptors. Benzyl quinolone carboxylic acid (BQCA) is an unprecedented example of a highly selective positive allosteric modulator o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e371e7b0c0a7a3e72488fd35f3574083
https://doi.org/10.1074/jbc.m113.536672
https://doi.org/10.1074/jbc.m113.536672
Autor:
Martin J. Scanlon, Philip J. Marriott, Yijun Pan, Jennifer L. Short, Christopher J.H. Porter, Joseph A. Nicolazzo, Kwok Ho Christopher Choy, Annie X. Zeng, Yuji Owada
Fatty acid-binding protein 5 (FABP5) at the blood–brain barrier contributes to the brain uptake of docosahexaenoic acid (DHA), a blood-derived polyunsaturated fatty acid essential for maintenance of cognitive function. Given the importance of DHA i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319a5f03ac97456ced5aa0927721e642
https://europepmc.org/articles/PMC6705637/
https://europepmc.org/articles/PMC6705637/
Autor:
Christopher J. Langmead, Kwok Ho Christopher Choy, Christos Pantelis, Peter J. Scammells, Johnathan R Lane, Daniel Thomas Malone, David M. Shackleford, Shailesh N. Mistry, Arthur Christopoulos, Patrick M. Sexton, Rahul T Patil
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 359(2)
Current antipsychotics are effective in treating the positive symptoms associated with schizophrenia, but they remain suboptimal in targeting cognitive dysfunction. Recent studies have suggested that positive allosteric modulation of the M1 muscarini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae172f171513b695e034eaaa902d83d
https://pubmed.ncbi.nlm.nih.gov/27630144
https://pubmed.ncbi.nlm.nih.gov/27630144
Autor:
Michael Kyrios, Rachel Anne Hill, Anthony J. Hannan, Maren Klug, Kwok Ho Christopher Choy, Maarten van den Buuse
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 3, Pp 722-731 (2012)
Psychiatric illnesses, such as schizophrenia, are most likely caused by an interaction between genetic predisposition and environmental factors, including stress during development. The neurotrophin, brain-derived neurotrophic factor (BDNF) has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fb8a39710c7e42064f54609d232b47
https://doi.org/10.1016/j.nbd.2012.03.015
https://doi.org/10.1016/j.nbd.2012.03.015
Publikováno v:
European Neuropsychopharmacology. 18:1-13
The development of schizophrenia may include an early neurodevelopmental stress component which increases vulnerability to later stressful life events, in combination leading to overt disease. We investigated the effect of an early stress, in the for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91df1332a205c57252d05af493c0a24
https://doi.org/10.1016/j.euroneuro.2007.03.011
https://doi.org/10.1016/j.euroneuro.2007.03.011