Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kwok F J Ng"'
Autor:
Xiaowen Mao, Tingting Wang, Yanan Liu, Michael G Irwin, Jing-song Ou, Xiao-long Liao, Xia Gao, Yuan Xu, Kwok F J Ng, Paul M Vanhoutte, Zhengyuan Xia
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68949 (2013)
To determine whether or not the antioxidants N-acetylcysteine (NAC) and allopurinol (ALP) confer synergistic cardioprotection against myocardial ischemia/reperfusion (MI/R) injury by stabilizing hypoxia inducible factor 1α (HIF-1α)/heme oxygenase 1
Externí odkaz:
https://doaj.org/article/63e5338ec2494a3ea3586564d6fe7997
Autor:
Tingting Wang, Shigang Qiao, Shaoqing Lei, Yanan Liu, Kwok F J Ng, Aimin Xu, Karen S L Lam, Michael G Irwin, Zhengyuan Xia
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23967 (2011)
Hyperglycemia-induced oxidative stress plays a central role in the development of diabetic myocardial complications. Adiponectin (APN), an adipokine with anti-diabetic and anti-ischemic effects, is decreased in diabetes. It is unknown whether or not
Externí odkaz:
https://doaj.org/article/27637289484b4f17abfecff88a5c6e3e
Publikováno v:
Anesthesiology. 128(3)
Background The α2-adrenergic sedative/anesthetic agent dexmedetomidine exerts biphasic effects on isolated arteries, causing endothelium-dependent relaxations at concentrations at or below 30 nM, followed by contractions at higher concentrations. l-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779bbba30e132fde725db0d957dc4984
https://pubmed.ncbi.nlm.nih.gov/29251642
https://pubmed.ncbi.nlm.nih.gov/29251642
Autor:
Junwen Wang, Shaoqing Lei, Kwok F. J. Ng, Tingting Wang, Aimin Xu, Zipeng Liu, Michael G. Irwin, Xiaowen Mao, Gordon Tin Chun Wong, Zhengyuan Xia, Paul M. Vanhoutte, Shigang Qiao, Haobo Li
Publikováno v:
Free Radical Biology and Medicine. 63:291-303
N-Acetylcysteine (NAC) and allopurinol (ALP) synergistically reduce myocardial ischemia reperfusion (MI/R) injury in diabetes. However, the mechanism is unclear. We postulated that NAC and ALP attenuated diabetic MI/R injury by up-regulating phosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c5a5030c25eaefceb8aa7350c4f9a8
https://doi.org/10.1016/j.freeradbiomed.2013.05.043
https://doi.org/10.1016/j.freeradbiomed.2013.05.043
Autor:
Xin-Liang Ma, Jinjin Xu, Wayne Bond Lau, Junwen Wang, Yanan Liu, Haobo Li, Michael G. Irwin, Brian Rodrigues, Shaoqing Lei, Kwok F. J. Ng, Zhengyuan Xia, Xia Gao
Publikováno v:
Diabetes
Protein kinase C (PKC)β2 is preferably overexpressed in the diabetic myocardium, which induces cardiomyocyte hypertrophy and contributes to diabetic cardiomyopathy, but the underlying mechanisms are incompletely understood. Caveolae are critical in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16518db286a97a54a36d5ad85ef50a0b
https://doi.org/10.2337/db12-1391
https://doi.org/10.2337/db12-1391
Publikováno v:
Anaesthesia. 66:999-1005
Mild hypothermia (34-35 °C) increases peri-operative blood loss. We have previously demonstrated the beneficial effect of in vitro desmopressin on impairment of primary haemostasis associated with hypothermia. This study evaluated subcutaneous desmo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4213213b1a71f75f77c36848cdb11448
https://doi.org/10.1111/j.1365-2044.2011.06821.x
https://doi.org/10.1111/j.1365-2044.2011.06821.x
Publikováno v:
Journal of Bone and Joint Surgery. 93:1268-1277
At present, individual techniques, including intraoperative acute normovolemic hemodilution, use of tranexamic acid, use of intrathecal morphine, proper positioning, and modification of operative techniques, seem most promising for reducing periopera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00ba1c001b816178573d2a4ca5d0a84
https://doi.org/10.2106/jbjs.j.01293
https://doi.org/10.2106/jbjs.j.01293
Autor:
Kwok F. J. Ng, Michael G. Irwin, Chi Wai Cheung, Chee Lun Aaron Ying, Wai Kuen Chiu, Wing Shan Choi
Publikováno v:
The Clinical Journal of Pain. 27:377-382
Objectives: To determine the analgesic effects of locally applied dexmedetomidine in third molar surgery under general anesthesia. Methods: Patients undergoing bilateral third molar surgery under general anesthesia were recruited into this double-bli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968498c0076b1e7cb2258edea4abeb71
https://doi.org/10.1097/ajp.0b013e318208c8c5
https://doi.org/10.1097/ajp.0b013e318208c8c5
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 335:659-664
Dexmedetomidine is an α(2)-adrenoceptor agonist and anesthetic. The present study was designed to characterize the receptor subtypes and the downstream mechanisms of the vascular effects of dexmedetomidine in small (mesenteric artery) and large (aor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b7f131b4efed6889ccd44eebfbe0c4
https://doi.org/10.1124/jpet.110.170688
https://doi.org/10.1124/jpet.110.170688
Autor:
Yiu Wa Kwan, Paul M. Vanhoutte, Chao Fan Liang, Alice Lai Shan Au, Michel Félétou, Kwok F. J. Ng, Ricky Y.K. Man, Susan W.S. Leung
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 334:223-231
The present experiments investigated whether endothelium-derived mediators modulate the effect of natriuretic peptides in porcine coronary arteries. Rings with and without endothelium were suspended in organ chambers for isometric tension recording.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40d07c257293d672f2025cd79e9a0b0
https://doi.org/10.1124/jpet.110.166652
https://doi.org/10.1124/jpet.110.166652