Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Kwi Hye Koh"'
Autor:
Changli Wei, Prasun K. Datta, Florian Siegerist, Jing Li, Sudhini Yashwanth, Kwi Hye Koh, Nicholas W. Kriho, Anis Ismail, Shengyuan Luo, Tracy Fischer, Kyle T. Amber, David Cimbaluk, Alan Landay, Nicole Endlich, Jay Rappaport, Michigan Medicine COVID−19 Investigators, Salim S. Hayek, Jochen Reiser
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Elevation in soluble urokinase receptor (suPAR) and proteinuria are common signs in patients with moderate to severe coronavirus disease 2019 (COVID-19). Here we characterize a new type of proteinuria originating as part of a viral response.
Externí odkaz:
https://doaj.org/article/db93bc99232647078412b7f98040292a
Autor:
Shivangi Agarwal, Kwi Hye Koh, Nicholas J. Tardi, Chuang Chen, Ranadheer Reddy Dande, Joao Pedro WerneckdeCastro, Yashwanth Reddy Sudhini, Cristina Luongo, Domenico Salvatore, Beata Samelko, Mehmet M. Altintas, Steve Mangos, Antonio Bianco, Jochen Reiser
Publikováno v:
EBioMedicine, Vol 72, Iss , Pp 103617- (2021)
ABSTRACT: Background: Nephrotic syndrome (NS) is associated with kidney podocyte injury and may occur as part of thyroid autoimmunity such as Graves’ disease. Therefore, the present study was designed to ascertain if and how podocytes respond to an
Externí odkaz:
https://doaj.org/article/ac26f616b0024f88b24df376bf577abf
Autor:
Kwon Tae You, Long Shan Li, Nam-Gyun Kim, Hyun Ju Kang, Kwi Hye Koh, Yong-Joon Chwae, Kyoung Mi Kim, Yoon Ki Kim, Sung Mi Park, Sung Key Jang, Hoguen Kim
Publikováno v:
PLoS Biology, Vol 5, Iss 5, p e109 (2007)
Frameshift and nonsense mutations are common in tumors with microsatellite instability, and mRNAs from these mutated genes have premature termination codons (PTCs). Abnormal mRNAs containing PTCs are normally degraded by the nonsense-mediated mRNA de
Externí odkaz:
https://doaj.org/article/1092f95f3d0347a88e4c4dc0dfec85d7
Autor:
Steve Mangos, Domenico Salvatore, Jochen Reiser, Ranadheer Reddy Dande, Kwi Hye Koh, Antonio C. Bianco, Chuang Chen, Joao Pedro WerneckdeCastro, Yashwanth Reddy Sudhini, Cristina Luongo, Nicholas J. Tardi, Beata Samelko, Shivangi Agarwal, Mehmet M. Altintas
Publikováno v:
EBioMedicine
EBioMedicine, Vol 72, Iss, Pp 103617-(2021)
EBioMedicine, Vol 72, Iss, Pp 103617-(2021)
Background: Nephrotic syndrome (NS) is associated with kidney podocyte injury and may occur as part of thyroid autoimmunity such as Graves’ disease. Therefore, the present study was designed to ascertain if and how podocytes respond to and regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df25212d328ab5b102e491f56f1abd6
http://europepmc.org/articles/PMC8517284
http://europepmc.org/articles/PMC8517284
Autor:
Zhongji Liao, Ke Zhu, Vasil Peev, Salim S. Hayek, Michael L. Merchant, Shuangxin Liu, Beata Samelko, Nicholas J. Tardi, Jochen Reiser, Stefan Hägele, Jon B. Klein, Brian D. Adair, Jianchao Ma, Sanford J. Shattil, M. Amin Arnaout, Jian Cai, Salvatore DiBartolo, Sanja Sever, Ranadheer R. Dande, Kwi Hye Koh, David Cimbaluk, Jing Li, Melissa Tracy, Changli Wei
Publikováno v:
J Clin Invest
Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived circulating signaling molecule that has been implicated in chronic kidney disease, such as focal segmental glomerulosclerosis (FSGS). Typically, native uPAR (isoform 1) tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699b545d832fda89d50d898ad6c77e57
https://doi.org/10.1172/jci124793
https://doi.org/10.1172/jci124793
Autor:
Vasil Peev, Eunsil Hahm, Hyun Lee, Nicholas J. Tardi, Ranadheer R. Dande, Mehmet M. Altintas, Cao Yanxia, Beata Samelko, Kamalika Mukherjee, Steve Mangos, Jochen Reiser, Vincent P. Schmitz, Kwi Hye Koh, Ha Won Lee, David Cimbaluk
Publikováno v:
Journal of Clinical Investigation. 129:1713-1726
Soluble urokinase receptor (suPAR) is a circulatory molecule that activates αvβ3 integrin on podocytes, causes foot process effacement, and contributes to proteinuric kidney disease. While active integrin can be targeted by antibodies and small mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901a54a68c8ed7e1beaacb1e51dbd939
https://doi.org/10.1172/jci123386
https://doi.org/10.1172/jci123386
Autor:
Changli Wei, Guohui Ren, Fumihiko Matsuda, Mehmet M. Altintas, Jochen Reiser, Kwi Hye Koh, Hidde L. Ploegh, Nicholas J. Tardi, Phillip Ruiz
Publikováno v:
American Journal of Physiology-Renal Physiology. 314:F471-F482
Podocytes are terminally differentiated cells of the kidney filtration barrier with a limited proliferative capacity and are the primary glomerular target for various sources of cellular stress. Accordingly, it is particularly important for podocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c660c93d2355ce4536caf568e19f8200
https://doi.org/10.1152/ajprenal.00691.2016
https://doi.org/10.1152/ajprenal.00691.2016
Autor:
Hyun Lee, Lesley A. Inker, Ranadheer R. Dande, Nikolina Stojanović, Garrett Garborcauskas, Beata Samelko, Jochen Reiser, Morgan E. Grams, Jing Li, Changli Wei, Vineet Gupta, Arshed A. Quyyumi, Martin Zeier, Jeffrey B. Kopp, Yi-An Ko, Vasil Peev, Mehmet M. Altintas, Andrew S. Levey, Salim S. Hayek, Sanja Sever, Kwi Hye Koh, Eunsil Hahm, Adrienne Tin, Cheryl A. Winkler, Ha Won Lee, Melissa Tracy, Nicholas J. Tardi, Michael S. Lipkowitz, Karl Skorecki, Josef Coresh, Barry I. Freedman
Soluble urokinase plasminogen activator receptor (suPAR) independently predicts chronic kidney disease (CKD) incidence and progression. Apolipoprotein L1 (APOL1) gene variants G1 and G2, but not the reference allele (G0), are associated with an incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8128e9677970ef545043ccbfebe4da58
https://www.bib.irb.hr/887558
https://www.bib.irb.hr/887558
Autor:
Hong Wu Shen, Kwi Hye Koh, Samuel L.M. Arnold, Xian Pan, Hyunyoung Jeong, Nina Isoherranen, Frank J. Gonzalez, Aiming Yu
Publikováno v:
The Journal of biological chemistry, vol 289, iss 6
Substrates of a major drug-metabolizing enzyme CYP2D6 display increased elimination during pregnancy, but the underlying mechanisms are unknown in part due to a lack of experimental models. Here, we introduce CYP2D6-humanized (Tg-CYP2D6) mice as an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319b44b75e957da256bc7f81fdb0f59a
https://doi.org/10.1074/jbc.m113.526798
https://doi.org/10.1074/jbc.m113.526798
Autor:
Salim S, Hayek, Kwi Hye, Koh, Morgan E, Grams, Changli, Wei, Yi-An, Ko, Jing, Li, Beata, Samelko, Hyun, Lee, Ranadheer R, Dande, Ha Won, Lee, Eunsil, Hahm, Vasil, Peev, Melissa, Tracy, Nicholas J, Tardi, Vineet, Gupta, Mehmet M, Altintas, Garrett, Garborcauskas, Nikolina, Stojanovic, Cheryl A, Winkler, Michael S, Lipkowitz, Adrienne, Tin, Lesley A, Inker, Andrew S, Levey, Martin, Zeier, Barry I, Freedman, Jeffrey B, Kopp, Karl, Skorecki, Josef, Coresh, Arshed A, Quyyumi, Sanja, Sever, Jochen, Reiser
Publikováno v:
Nature medicine. 23(8)
Soluble urokinase plasminogen activator receptor (suPAR) independently predicts chronic kidney disease (CKD) incidence and progression. Apolipoprotein L1 (APOL1) gene variants G1 and G2, but not the reference allele (G0), are associated with an incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee3c13bb91e417a33b8631812c6f0a6f
https://pubmed.ncbi.nlm.nih.gov/28669990
https://pubmed.ncbi.nlm.nih.gov/28669990