Výsledky vyhledávání - "Kweku Ofosu-Asante"

Akademický článek

Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis.

Autor: Matthew D Gregory, Kweku Ofosu-Asante, Jassy Mary S Lazarte, Pablo E Puente, Nada Tawfeeq, Nadine Belony, Yong Huang, Ite A Offringa, Nazarius S Lamango

Publikováno v: PLoS ONE, Vol 19, Iss 10, p e0312563 (2024)

KRAS mutations are the most common oncogenic mutations in lung adenocarcinoma in Black Americans. Polyisoprenylated Cysteinyl amide Inhibitors (PCAIs) constitute a group of potential cancer therapy agents that we designed to specifically disrupt and

Externí odkaz: https://doaj.org/article/162c4ca0528449b8afb30f6d38461cf8

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Abstract 4043: Stimulation of the mapk and pi3k/akt pathways in pancreatic cancer cells by polyisoprenylated cysteinyl amide inhibitors

Autor: Kweku Ofosu-Asante, Jassy M. Lazarte, Amarendar G. Burra, Nazarius S. Lamango

Publikováno v: Cancer Research. 83:4043-4043

Pancreatic cancer is the third deadliest cancer with a 5-year survival rate of less than 10%. Over 90% of reported cases are driven by KRAS mutations. KRAS signals through the MAPK and PI3K pathways. Targeting mutant KRAS has been a decades-long chal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec51cb2c7ef59dcea998bd52c6270f78
https://doi.org/10.1158/1538-7445.am2023-4043

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