Genetic predisposition to coronary artery disease in type 2 diabetes

Autor: van Zuydam, NR, Ladenvall, C, Voight, BF, Strawbridge, RJ, Fernandez Tajes, J, Rayner, NW, Robertson, NR, Mahajan, A, Vlachopoulou, E, Goel, A, Kleber, ME, Nelson, CP, Kwee, LC, Esko, T, Mihailov, E, Mägi, R, Milani, L, Fischer, K, Kanoni, S, Kumar, J, Song, C, Hartiala, JA, Pedersen, NL, Perola, M, Gieger, C, Peters, A, Qu, L, Willems, SM, Doney, ASF, Morris, AD, Zheng, Y, Sesti, G, Hu, FB, Qi, L, Laakso, M, Thorsteinsdottir, U, Grallert, H, van Duijn, C, Reilly, MP, Ingelsson, E, Deloukas, P, Kathiresan, S, Metspalu, A, Shah, SH, Sinisalo, J, Salomaa, V, Hamsten, A, Samani, NJ, März, W, Hazen, SL, Watkins, H

Background - Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes (T2D). Methods - To test whether this reflects differential genetic influences on CAD-risk in subjects with T2D, we performed a systematic assessment of geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::7ca3630440a72193c14d4329f1ec70c0
https://doi.org/10.1161/circgen.119.002769

Metabolic Effects of the SGLT2 Inhibitor Dapagliflozin in Heart Failure Across the Spectrum of Ejection Fraction.

Autor: Selvaraj S; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC (S.S., R.W.M., R.J.M., S.H.S.).; Duke Molecular Physiology Institute, Duke University, Durham, NC (S.S., R.W.M., L.C.K., O.I., M.J.M., C.B.N., S.H.S.)., Patel S; Saint Luke's Mid America Heart Institute, Kansas City, MO (S.P., A.J.S., P.J., S.L.W., M.N.K.)., Sauer AJ; Saint Luke's Mid America Heart Institute, Kansas City, MO (S.P., A.J.S., P.J., S.L.W., M.N.K.).; University of Missouri-Kansas City (A.J.S., M.N.K.)., McGarrah RW; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC (S.S., R.W.M., R.J.M., S.H.S.).; Duke Molecular Physiology Institute, Duke University, Durham, NC (S.S., R.W.M., L.C.K., O.I., M.J.M., C.B.N., S.H.S.)., Jones P; Saint Luke's Mid America Heart Institute, Kansas City, MO (S.P., A.J.S., P.J., S.L.W., M.N.K.)., Kwee LC; Duke Molecular Physiology Institute, Duke University, Durham, NC (S.S., R.W.M., L.C.K., O.I., M.J.M., C.B.N., S.H.S.)., Windsor SL; Saint Luke's Mid America Heart Institute, Kansas City, MO (S.P., A.J.S., P.J., S.L.W., M.N.K.)., Ilkayeva O; Duke Molecular Physiology Institute, Duke University, Durham, NC (S.S., R.W.M., L.C.K., O.I., M.J.M., C.B.N., S.H.S.).; Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University School of Medicine, Durham, NC (O.I.)., Muehlbauer MJ; Duke Molecular Physiology Institute, Duke University, Durham, NC (S.S., R.W.M., L.C.K., O.I., M.J.M., C.B.N., S.H.S.)., Newgard CB; Duke Molecular Physiology Institute, Duke University, Durham, NC (S.S., R.W.M., L.C.K., O.I., M.J.M., C.B.N., S.H.S.)., Borlaug BA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (B.A.B.)., Kitzman DW; Department of Internal Medicine, Sections on Cardiovascular Medicine and Geriatrics, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Shah SJ; Division of Cardiology, Department of Medicine, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.)., Margulies KB; Division of Cardiology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia (K.B.M.)., Husain M; Ted Rogers Centre for Heart Research, University of Toronto, ON, Canada (M.H.)., Inzucchi SE; Yale University School of Medicine, New Haven, CT (S.E.I.)., McGuire DK; University of Texas Southwestern Medical Center and Parkland Health and Hospital System, Dallas (D.K.M.)., Lanfear DE; Center for Individual and Genomic Medicine Research and Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI (D.E.L.)., Javaheri A; Washington University School of Medicine, St. Louis, MO (A.J.)., Umpierrez G; Division of Endocrinology, Emory University School of Medicine, Atlanta, GA (G.U.)., Mentz RJ; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC (S.S., R.W.M., R.J.M., S.H.S.)., Sharma K; Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (K.S.)., Kosiborod MN; Saint Luke's Mid America Heart Institute, Kansas City, MO (S.P., A.J.S., P.J., S.L.W., M.N.K.).; University of Missouri-Kansas City (A.J.S., M.N.K.)., Shah SH; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC (S.S., R.W.M., R.J.M., S.H.S.).; Duke Molecular Physiology Institute, Duke University, Durham, NC (S.S., R.W.M., L.C.K., O.I., M.J.M., C.B.N., S.H.S.).

Publikováno v: Circulation. Heart failure [Circ Heart Fail] 2024 Nov; Vol. 17 (11), pp. e011980. Date of Electronic Publication: 2024 Oct 18.

Targeted Metabolomic Profiling of Dapagliflozin in Heart Failure With Preserved Ejection Fraction: The PRESERVED-HF Trial.

Autor: Selvaraj S; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA; Duke Molecular Physiology Institute, Durham, North Carolina, USA., Patel S; Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA., Sauer AJ; Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA; University of Missouri-Kansas City, Kansas City, Missouri, USA., McGarrah RW; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA; Duke Molecular Physiology Institute, Durham, North Carolina, USA., Jones P; Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA., Kwee LC; Duke Molecular Physiology Institute, Durham, North Carolina, USA., Windsor SL; Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA., Ilkayeva O; Duke Molecular Physiology Institute, Durham, North Carolina, USA; Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA., Muehlbauer MJ; Duke Molecular Physiology Institute, Durham, North Carolina, USA., Newgard CB; Duke Molecular Physiology Institute, Durham, North Carolina, USA., Borlaug BA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Kitzman DW; Department of Internal Medicine, Sections on Cardiovascular Medicine and Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Shah SJ; Division of Cardiology, Department of Medicine and Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Shah SH; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA; Duke Molecular Physiology Institute, Durham, North Carolina, USA., Kosiborod MN; Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA; University of Missouri-Kansas City, Kansas City, Missouri, USA. Electronic address: mkosiborod@saint-lukes.org.

Publikováno v: JACC. Heart failure [JACC Heart Fail] 2024 Jun; Vol. 12 (6), pp. 999-1011. Date of Electronic Publication: 2024 Apr 17.

Associations among NMR-measured inflammatory and metabolic biomarkers and accelerated aging in cardiac catheterization patients.

Autor: Raab H; Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC 27514, USA., Hauser ER; Duke University Molecular Physiology Institute, Duke University, Durham, NC 27701, USA., Kwee LC; Duke University Molecular Physiology Institute, Duke University, Durham, NC 27701, USA., Shah SH; Duke University Molecular Physiology Institute, Duke University, Durham, NC 27701, USA., Kraus WE; Duke University Molecular Physiology Institute, Duke University, Durham, NC 27701, USA., Ward-Caviness CK; Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC 27514, USA.

Publikováno v: Aging [Aging (Albany NY)] 2024 Apr 23; Vol. 16 (8), pp. 6652-6672. Date of Electronic Publication: 2024 Apr 23.

Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder.

Autor: Siecinski SK; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Giamberardino SN; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Spanos M; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA., Hauser AC; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Gibson JR; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Chandrasekhar T; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA., Trelles MDP; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Rockhill CM; Department of Psychiatry, Seattle Children's Hospital and the University of Washington, Seattle, Washington, USA., Palumbo ML; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Cundiff AW; Department of Psychiatry, Vanderbilt University, Nashville, Tennessee, USA., Montgomery A; Department of Psychiatry, Columbia University, New York, New York, USA., Siper P; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Minjarez M; Department of Psychiatry, Seattle Children's Hospital and the University of Washington, Seattle, Washington, USA., Nowinski LA; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Marler S; Department of Psychiatry, Vanderbilt University, Nashville, Tennessee, USA., Kwee LC; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Shuffrey LC; Department of Psychiatry, Columbia University, New York, New York, USA., Alderman C; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.; Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA., Weissman J; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Zappone B; Department of Psychiatry, Seattle Children's Hospital and the University of Washington, Seattle, Washington, USA., Mullett JE; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Crosson H; Department of Psychiatry, Columbia University, New York, New York, USA., Hong N; Department of Psychiatry, Columbia University, New York, New York, USA., Luo S; Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA., She L; Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA., Bhapkar M; Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA., Dean R; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Scheer A; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA., Johnson JL; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., King BH; Department of Psychiatry, Seattle Children's Hospital and the University of Washington, Seattle, Washington, USA., McDougle CJ; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Sanders KB; Department of Psychiatry, Vanderbilt University, Nashville, Tennessee, USA., Kim SJ; Department of Psychiatry, Seattle Children's Hospital and the University of Washington, Seattle, Washington, USA., Kolevzon A; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Veenstra-VanderWeele J; Department of Psychiatry, Columbia University, New York, New York, USA., Hauser ER; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA., Sikich L; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.; Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA., Gregory SG; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Neurology, Duke University School of Medicine, Durham, North Carolina, USA.

Publikováno v: Autism research : official journal of the International Society for Autism Research [Autism Res] 2023 Mar; Vol. 16 (3), pp. 502-523. Date of Electronic Publication: 2023 Jan 07.