Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Kwee Hyun Suh"'
Autor:
Joo-Yun Byun, Yi T. Koh, Sun Young Jang, Jennifer W. Witcher, Jason R. Chan, Anna Pustilnik, Mark J. Daniels, Young Hoon Kim, Kwee Hyun Suh, Matthew D. Linnik, Young-Mi Lee
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The selective Bruton tyrosine kinase (BTK) inhibitor poseltinib has been shown to inhibit the BCR signal transduction pathway and cytokine production in B cells (Park et al. Arthritis Res. Ther. 18, 91, https://doi.org/10.1186/s13075-016-098
Externí odkaz:
https://doaj.org/article/f84752f1ec4c42a4a963b56dd9003005
Autor:
Dong Jin Hong, Seung Hyun Jung, Jisook Kim, Danbee Jung, Young Gil Ahn, Kwee Hyun Suh, Kyung Hoon Min
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 227-234 (2020)
A novel series of thieno[3,2-d]pyrimidine derivatives were synthesised and their inhibitory effects against diacylglycerol acyltransferase 1 (DGAT-1) were assessed. cis-Isomer 17a showed potent and selective inhibitory activity against DGAT-1 in SF9
Externí odkaz:
https://doaj.org/article/ada32c039eff4462af7a5b7bd0b18055
Autor:
Seok Jong Kang, Jung Wuk Lee, Jiho Song, Jiwon Park, Jaeyul Choi, Kwee Hyun Suh, Kyung Hoon Min
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1928-1936 (2020)
The importance of transforming growth factor beta-activated kinase 1 (TAK1) to cell survival has been demonstrated in many studies. TAK1 regulates signalling cascades, the NF-κB pathway and the mitogen-activated protein kinase (MAPK) pathway. TAK1 i
Externí odkaz:
https://doaj.org/article/5e9ed51efe3046938b526d57fc280129
Autor:
Yu-Yon Kim, Ki Tae Park, Sun Young Jang, Kyu Hang Lee, Joo-Yun Byun, Kwee Hyun Suh, Young-Mi Lee, Young Hoon Kim, Kwang Woo Hwang
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-11 (2017)
Abstract Background Systemic lupus erythematosus (SLE) is associated with B cell hyperactivity, and lupus nephritis (LN), in particular, is promoted by the production of autoantibodies and immune complex deposition. Bruton’s tyrosine kinase (BTK) p
Externí odkaz:
https://doaj.org/article/909005a489cb46f6935126542d41f02a
Autor:
Yu-Yon Kim, Hyunjin Park, Taehun Song, Kyungjin Choi, Michael Dolton, Jialin Mao, Jisook Kim, Young Gil Ahn, Kwee Hyun Suh, Young Hoon Kim
Publikováno v:
Clinical & Experimental Metastasis. 40:137-148
Autor:
Murray Cutler, Gwan-Sun Lee, Laura Pitzonka, Johnson Y.N. Lau, Sameer Urgaonkar, Kwee Hyun Suh, Michael Smolinski
Publikováno v:
Journal of Medicinal Chemistry. 64:3677-3693
Many chemotherapeutics, such as paclitaxel, are administered intravenously as they suffer from poor oral bioavailability, partly because of efflux mechanism of P-glycoprotein in the intestinal epithelium. To date, no drug has been approved by the U.S
Autor:
Seung Hyun Jung, Jaeyul Choi, Wongi Park, Jooyun Byun, Semi Lim, Youngjoo Lee, Yu-Yon Kim, Hyunjin Park, So-Ye Jeon, Taehun Song, Kyungjin Choi, Tae-yeon Kong, Heecheol Kim, Wook Jang, EunYoung Lee, Minhwa Kim, Young Gil Ahn, Young Hoon Kim, Kwee Hyun Suh
Publikováno v:
Cancer Research. 83:1625-1625
KRAS is a well-known oncogene with the highest mutation rate among various cancers. KRAS cycles between GDP-loaded ‘off’ and GTP-loaded ‘on’ states induce downstream signal transduction to promote cell proliferation and survival. Interconvers
Autor:
Jisook Kim, Seung Hyun Jung, Seon Yeong Han, Jihee Yoon, Minjeong Kim, Jooyun Byun, Heesun Moon, Eunyoung Lee, Yu-Yon Kim, Hyunjin Park, So-Ye Jeon, Young Gil Ahn, Young Hoon Kim, Kwee Hyun Suh
Publikováno v:
Cancer Research. 83:1614-1614
The Hippo pathway is evolutionarily conserved and known to regulate diverse cellular processes, including cell survival, proliferation, differentiation, migration, and organ size. The key regulator of Hippo pathway is transcriptional enhanced associa
Autor:
Jooyun Byun, Seung Hyun Jung, Yu-Yon Kim, Miyoung Lee, Gunwoo Lee, Heesun Moon, Eun Young Lee, Junghwa Park, Seon Yeong Han, Young Gil Ahn, Young Hoon Kim, Kwee Hyun Suh
Publikováno v:
Cancer Research. 83:6267-6267
Chromatin remodeling is a crucial process for transcriptional regulation, of which dysregulation is often observed in various human cancers. The enhancer of zeste homology 2 (EZH2) and its homolog EZH1 are catalytic subunits of polycomb repressive co
Autor:
Yu-Yon Kim, Kyung Jin Choi, Young Gil Ahn, Sun Young Jang, Young Hoon Kim, Kwee Hyun Suh, Hyung Sik Kim
Publikováno v:
In Vivo
Background/Aim: Using a rat model of collagen-induced arthritis (CIA), we evaluated the therapeutic effects of HM71224 (BTKi), as well as the drug-drug interactions in combined therapy with methotrexate (MTX) based on both drugs’ pharmacological ro