Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kwangwook Ahn"'
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28179 (2011)
Increase in the generation and deposition of amyloid-β (Aβ) plays a central role in the development of Alzheimer's Disease (AD). Elevation of the activity of γ-secretase, a key enzyme required for the generation for Aβ, can thus be a potential ri
Externí odkaz:
https://doaj.org/article/a4fcc79002c149389d7bf4eb87eb1d0c
Publikováno v:
NeuroReport. 25:549-555
In this study, we found that BMP2 exerts neurotrophic effects, including a neuroprotective effect against nocodazole-induced neuritic degeneration, on neuronal cells. We also found that BMP2-induced neurotrophic effects are directly involved in Smad-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13953f37c7a2d8e97c9c61f97dfb3ac6
https://doi.org/10.1097/wnr.0000000000000130
https://doi.org/10.1097/wnr.0000000000000130
Autor:
Christopher W. am Ende, Kelly R. Bales, Douglas S. Johnson, Kwangwook Ahn, Heather E. Murrey, Christina J. Crump, Nikolay Pozdnyakov, Martin Pettersson, T. Eric Ballard, Yue-Ming Li
Publikováno v:
Journal of Biological Chemistry. 288:9710-9720
γ-Secretase is an intramembrane aspartyl protease that cleaves the amyloid precursor protein to produce neurotoxic β-amyloid peptides (i.e. Aβ42) that have been implicated in the pathogenesis of Alzheimer disease. Small molecule γ-secretase modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be67af06cfe100c03f2092ad6d781819
https://doi.org/10.1074/jbc.m112.398602
https://doi.org/10.1074/jbc.m112.398602
Autor:
Georgia Dolios, Marcin Paduch, Kwangwook Ahn, Yue-Ming Li, Rong Wang, Akiko Koide, Robert J. Hoey, Shohei Koide, Xulun Zhang, Takeshi Ikeuchi, Sangram S. Sisodia, Brenda Leung, Guoqing Lin
Publikováno v:
Proceedings of the National Academy of Sciences. 109:8534-8539
The γ-secretase complex, composed of presenilin, anterior-pharynx-defective 1, nicastrin, and presenilin enhancer 2, catalyzes the intramembranous processing of a wide variety of type I membrane proteins, including amyloid precursor protein (APP) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b3f3ed535e6f09db1ed0f7cf694243
https://doi.org/10.1073/pnas.1202691109
https://doi.org/10.1073/pnas.1202691109
Publikováno v:
Analytical chemistry. 88(2)
Investigation of intramembranal protease catalysis demands the generation of intact biomembrane assemblies with structural integrity and lateral mobility. Here, we report the development of a microsphere supported-biomembrane platform enabling charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785c35c0efcaa42cc70c93128a9e65a7
https://pubmed.ncbi.nlm.nih.gov/26699370
https://pubmed.ncbi.nlm.nih.gov/26699370
Autor:
Christina J. Crump, Suita V. Castro, De-Ming Chau, Kelly R. Bales, Kwangwook Ahn, Yue-Ming Li, Cory Michael Stiff, Natalya Gertsik, Benjamin Adam Fish, Nikolay Pozdnyakov, Douglas S. Johnson
Publikováno v:
ACS Chemical Neuroscience. 2:705-710
Aβ42 is believed to play a causative role in Alzheimer's disease (AD) pathogenesis. γ-Secretase modulators (GSMs) are actively being pursued as potential AD therapeutics because they selectively alter the cleavage site of the amyloid precursor prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7ba6379cb95a4804101bef2a84e5f8
https://doi.org/10.1021/cn200098p
https://doi.org/10.1021/cn200098p
Autor:
Yuan Tian, Kwangwook Ahn, Yue-Ming Li, M. Lane Gilchrist, Christopher C. Shelton, Xulun Zhang, Sangram S. Sisodia
Publikováno v:
Proceedings of the National Academy of Sciences. 107:21435-21440
A complex composed of presenilin (PS), nicastrin, PEN-2, and APH-1 is absolutely required for γ-secretase activity in vivo. Evidence has emerged to suggest a role for PS as the catalytic subunit of γ-secretase, but it has not been established that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3d0c776efa7ee351ff051a7961971a
https://doi.org/10.1073/pnas.1013246107
https://doi.org/10.1073/pnas.1013246107
Autor:
Sangram S. Sisodia, Rudolph E. Tanzi, Chengzhi Yu, Anne M. Danks, Soan Cheng, Gonul Velicelebi, Kenneth A. Stauderman, Kwangwook Ahn, Yue-Ming Li, Elizabeth J. Ackerman, Dan Comer, Paul J. Digregorio, Phuong T. Nguyen, William T. Comer, Long Mao, David P. M. Pleynet, Xulun Zhang, Maria Z. Kounnas, Steven L. Wagner, William C. Mobley, Curtis M. Tyree
Alzheimer's disease (AD) is characterized pathologically by the abundance of senile plaques and neurofibrillary tangles in the brain. We synthesized over 1200 novel gamma-secretase modulator (GSM) compounds that reduced Abeta(42) levels without inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e0cce1c4de406c2d5b743c7ab53d04
https://europepmc.org/articles/PMC2947312/
https://europepmc.org/articles/PMC2947312/
Publikováno v:
Biochemistry. 47(46)
Rhomboid, a polytopic membrane serine protease, represents a unique class of proteases that cleave substrates within the transmembrane domain. Elucidating the mechanism of this extraordinary catalysis comes with inherent challenges related to membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17930d8891e0c91f93d999a2a0a083e5
https://pubmed.ncbi.nlm.nih.gov/18937501
https://pubmed.ncbi.nlm.nih.gov/18937501
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28179 (2011)
PLoS ONE
PLoS ONE
Increase in the generation and deposition of amyloid-β (Aβ) plays a central role in the development of Alzheimer's Disease (AD). Elevation of the activity of γ-secretase, a key enzyme required for the generation for Aβ, can thus be a potential ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053504fc7bb35480b60029bb2f41b811
https://doi.org/10.1371/journal.pone.0028179
https://doi.org/10.1371/journal.pone.0028179