Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kwangseok Ko"'
Autor:
Kwangseok Ko, Chan Hee Park, Seung-Su Oh, Young Jin Kwon, Jung-Sook Kim, Eun-Jung Park, Woul-Seong Park, Soon Ok Lee, D.H. Yoon, Woon-Ki Cho, Yu-Mi Song, Kyoung-June Lee, Cho-Rong Min, Jieun Lee, Kazumi Morikawa, Ju-Han Yoon, Pil-Su Ho, Hye Jung Kim, Jee-Hun Yun, Yu Chul Kim
Publikováno v:
Journal of Medicinal Chemistry. 61:2949-2961
The histamine H4 receptor (H4R), a member of the G-protein coupled receptor family, has been considered as a potential therapeutic target for treating atopic dermatitis (AD). A large number of H4R antagonists have been disclosed, but no efficient age
Autor:
Kwangseok Ko, Hangun Kim, Hyeon Sik Kim, Ayoung Pyo, Dong-Yeon Kim, Nam-Chul Cho, Jun Young Lee, Jeong Hoon Park, Kunal N. More, Dong-Jo Chang, Misun Yun
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:915-921
Carbonic anhydrase IX is overexpressed in many solid tumors including hypoxic tumors and is a potential target for cancer therapy and diagnosis. Reported imaging agents targeting CA-IX are successful mostly in clear cell renal carcinoma as SKRC-52 an
Autor:
Kunal N, More, Jun Young, Lee, Dong-Yeon, Kim, Nam-Chul, Cho, Ayoung, Pyo, Misun, Yun, Hyeon Sik, Kim, Hangun, Kim, Kwangseok, Ko, Jeong-Hoon, Park, Dong-Jo, Chang
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(14)
Autor:
Kunal N, More, Jun Young, Lee, Dong-Yeon, Kim, Nam-Chul, Cho, Ayoung, Pyo, Misun, Yun, Hyeon Sik, Kim, Hangun, Kim, Kwangseok, Ko, Jeong-Hoon, Park, Dong-Jo, Chang
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(5)
Carbonic anhydrase IX is overexpressed in many solid tumors including hypoxic tumors and is a potential target for cancer therapy and diagnosis. Reported imaging agents targeting CA-IX are successful mostly in clear cell renal carcinoma as SKRC-52 an
Autor:
Nam-Chul Cho, Kwangseok Ko, Hyeon Sik Kim, Jun Young Lee, Ayoung Pyo, Dong-Yeon Kim, Kunal N. More, Jeong Hoon Park, Hangun Kim, Dong-Jo Chang, Misun Yun
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2574
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:3090-3097
Racemate physicochemical descriptors are employed to probe the quantitative structure-activity relationship of spirosuccinimide type aldose reductase inhibitors and the in vivo inhibitory activity of sorbitol accumulation. The in vivo activity data i
Autor:
Kwangseok Ko, Zigang Dong, Bu Young Choi, Feng Zhu, Bong Seok Kang, Yong-Yeon Cho, Wei-Ya Ma, Hong Seok Choi, Ann M. Bode, Svetlana P. Ermakova
Publikováno v:
Nature Structural & Molecular Biology. 12:699-707
Inactivation of the p16(INK4a) tumor suppressor protein is critical for the development of human cancers, including human melanoma. However, the molecular basis of the protein's inhibitory effect on cancer development is not clear. Here we investigat
Autor:
Youngdo Won, Kwangseok Ko
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:1445-1452
We investigate the quantitative structure-activity relationship of spirosuccinimide-fused tetrahydropyrrolo[1,2-a]pyrazine-1,3-dione derivatives acting as aldose reductase inhibitors, which contain a chiral center. The published assay data of 30 trai
Autor:
Takaaki A. Fukami, Kwangseok Ko, Hiroshi Koyano, Hiroki Nishii, Takashi Chiba, Kenji Morikami, Hiroshi Sakamoto
Publikováno v:
ChemInform. 41
A novel quinoline derivative that selectively inhibits c-Met kinase was identified. The molecular design is based on a result of the analysis of a PF-2341066 (1)/c-Met cocrystal structure (PDB code: 2wgj). The kinase selectivity of the derivatives is
Autor:
Kwangseok Ko, Hiroshi Koyano, Takashi Chiba, Hiroki Nishii, Hiroshi Sakamoto, Kenji Morikami, Takaaki A. Fukami
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(4)
A novel quinoline derivative that selectively inhibits c-Met kinase was identified. The molecular design is based on a result of the analysis of a PF-2341066 (1)/c-Met cocrystal structure (PDB code: 2wgj). The kinase selectivity of the derivatives is