Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Kwangmin, Choi"'
Autor:
Haruki Watanabe, Minakshi Rana, Myoungsun Son, Pui Yan Chiu, Yurong Fei-Bloom, Kwangmin Choi, Betty Diamond, Barbara Sherry
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-22 (2024)
Abstract Background Sepsis survivors exhibit immune dysregulation that contributes to poor long-term outcomes. Phenotypic and functional alterations within the myeloid compartment are believed to be a contributing factor. Here we dissect the cellular
Externí odkaz:
https://doaj.org/article/cd20bcf3fc7f4dae8d46999c17da69b2
Autor:
Ashley E. Culver-Cochran, Aishlin Hassan, Kathleen Hueneman, Kwangmin Choi, Averil Ma, Brett VanCauwenbergh, Eric O’Brien, Mark Wunderlich, John P. Perentesis, Daniel T. Starczynowski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Acute myeloid leukemia (AML) is a deadly hematopoietic malignancy. Although many patients achieve complete remission with standard induction therapy, a combination of cytarabine and anthracycline, ~40% of patients have induction failure. The
Externí odkaz:
https://doaj.org/article/356edbda75cf4decb86051b5cb964a65
Autor:
Laura Barreyro, Avery M. Sampson, Kathleen Hueneman, Kwangmin Choi, Susanne Christie, Vighnesh Ramesh, Michael Wyder, Dehua Wang, Mario Pujato, Kenneth D. Greis, Gang Huang, Daniel T. Starczynowski
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109809- (2024)
Summary: Dysregulated innate immune signaling is linked to preleukemic conditions and myeloid malignancies. However, it is unknown whether sustained innate immune signaling contributes to malignant transformation. Here we show that cell-intrinsic inn
Externí odkaz:
https://doaj.org/article/27e314a429b04c5388a0550ebdd9ec6f
Autor:
Tomoya Muto, Callum S. Walker, Puneet Agarwal, Eric Vick, Avery Sampson, Kwangmin Choi, Madeline Niederkorn, Chiharu Ishikawa, Kathleen Hueneman, Melinda Varney, Daniel T. Starczynowski
Publikováno v:
Haematologica, Vol 108, Iss 10 (2023)
Inflammation is associated with the pathogenesis of myelodysplastic syndromes (MDS) and emerging evidence suggests that MDS hematopoietic stem and progenitor cells (HSPC) exhibit an altered response to inflammation. Deletion of chromosome 5 (del(5q))
Externí odkaz:
https://doaj.org/article/38750250ce874c0bb56f9b40f35e488d
Autor:
Leah J. Kershner, Kwangmin Choi, Jianqiang Wu, Xiyuan Zhang, Melissa Perrino, Nathan Salomonis, Jack F. Shern, Nancy Ratner
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
To define alterations early in tumor formation, we studied nerve tumors in neurofibromatosis 1 (NF1), a tumor predisposition syndrome. Affected individuals develop neurofibromas, benign tumors driven by NF1 loss in Schwann cells (SCs). By comparing n
Externí odkaz:
https://doaj.org/article/50276e58914543fb9bda0e1f1e2739c2
Autor:
Puneet Agarwal, Hui Li, Kwangmin Choi, Kathleen Hueneman, Jianbo He, Robert S. Welner, Daniel T. Starczynowski, Ravi Bhatia
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109386- (2021)
Summary: Chronic myeloid leukemia (CML) is propagated by leukemia stem cells (LSCs) that are not eradicated by tyrosine kinase inhibitor (TKI) treatment and persist as a source of disease recurrence. Bone marrow (BM) mesenchymal niches play an essent
Externí odkaz:
https://doaj.org/article/0559a6200b904336acf190e8f10c7f7b
Publikováno v:
Archives of Metallurgy and Materials, Vol vol. 64, Iss No 2, Pp 475-479 (2019)
An understanding of the fundamental correlation between grain size and material damping is crucial for the successful development of structural components offering high strength and good mechanical energy absorption. With this regard, we fabricated a
Externí odkaz:
https://doaj.org/article/4b900a705a284dd0944d38f65e2cd070
Autor:
Kwangmin Choi, Nancy Ratner
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-7 (2019)
Abstract Background The use of microarrays and RNA-seq technologies is ubiquitous for transcriptome analyses in modern biology. With proper analysis tools, the differential gene expression analysis process can be significantly accelerated. Many open-
Externí odkaz:
https://doaj.org/article/b90c01e4d2e84debae23b11965acb796
Autor:
Youjin Na, Ashley Hall, Yanan Yu, Liang Hu, Kwangmin Choi, Jake A. Burgard, Sara Szabo, Gang Huang, Nancy Ratner, Jianqiang Wu
Publikováno v:
Oncogene
Neurofibromatosis type 1 (NF1) patients are predisposed to develop plexiform neurofibromas (PNFs). Three endoplasmic reticulum (ER) stress response pathways restore cellular homeostasis. The unfolded protein response (UPR) sensors contribute to tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2615e8ed010ab41e6ebba61f8262c57f
https://doi.org/10.1038/s41388-023-02620-x
https://doi.org/10.1038/s41388-023-02620-x
Insight on Transcriptional Regulation of the Energy Sensing AMPK and Biosynthetic mTOR Pathway Genes
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The Adenosine Monophosphate-activated Protein Kinase (AMPK) and the Mechanistic Target of Rapamycin (mTOR) are two evolutionarily conserved kinases that together regulate nearly every aspect of cellular and systemic metabolism. These two kinases sens
Externí odkaz:
https://doaj.org/article/810092ee6feb4b07800d8a44a2299445